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99,167 grants found
Showing 96,241 – 96,260 of 99,167 grants
Regulation of vascular metabolism in acute lung injury
Project Summary/Abstract The proposal outlines an integrated research and career development plan for David Wu, MD PhD, to com- plete postdoctoral training in the laboratories of G...
Delineating developmental programs driving tumorigenesis in triple-negative breast cancer
PROJECT SUMMARY Triple-negative breast cancer (TNBC) is the deadliest and 2nd most common subtype of breast cancer in the United States. Although promising new drugs based on PARP...
Genomic and systemic approaches to evolutionary mechanisms
Project Summary The long-term objective of the PI's research program is to discover and understand general principles of evolution in terms of molecular genetic mechanisms and...
Structure, Mechanism and Interactions of Type IA Topoisomerases
Project Summary/Abstract Type IA topoisomerases are ubiquitous in the three kingdoms of life, and play critically important roles in maintaining proper DNA topology during the vita...
Risk for Later-Life Cognitive Impairment, Neurobehavioral Dysregulation, and Dementia in Former Soccer and American Football Players: The Head Impact and Trauma Surveillance Study (HITSS)
Exposure to repetitive head impacts (RHI) through participation in contact and collision sports (CCS) can result in symptomatic concussions and asymptomatic subconcussions and may...
On differentiating selective and neutral evolutionary processes
ABSTRACT At the founding of population genetics in the early 20th century, S. Wright and R.A. Fisher developed much of the mathematical and conceptual framework underlying the stud...
Deep tensor genomic imputation
Project Summary/Abstract High-throughput sequencing assays allow scientists to measure biochemical properties like transcription factor binding, histone modifications, and gene expr...
Mitotic transmission of acentric chromosome fragments
The goal of this proposal is to elucidate the molecular and cellular basis of a newly discovered diverse set of adaptive mechanisms that maintain the integrity of the genome during...
Mechanisms for building and remodeling microtubule arrays
Project Summary Control of the internal organization of cells is essential to the form and function of all organisms. This ability rests largely on an intricate protein filament ne...
Protein Networks as Synergistic Drivers of Membrane Remodeling
Summary Abstract: Protein Networks as Synergistic Drivers of Membrane Remodeling Membrane curvature is required for many cellular processes, from assembly of highly curved traffick...
TRPV4 Regulates Mechanosensitive Macrophage Functions in Lung Injury
PROJECT SUMMARY/ABSTRACT Overwhelming bacterial pneumonia injures and stiffens the lung leading to acute respiratory distress syndrome (ARDS) that carries a mortality of up to 50%....
The role of CELF2 and its genetic variants in Alzheimer's disease
Age is the most important risk factor for Alzheimer's disease (AD), but the occurrence of this disease is also affected by environmental factors, individual experience and gen...
Harnessing multiplexed Cas9 genome editing for sequential genetic manipulations and recording activities in cell lineages
SUMMARY Time is a problem for biologists, especially for those interested in cancer, stem cell, and developmental biology. Whereas cellular processes occur in real time, we most of...
Nuclear Organization and Function
PROJECT SUMMARY. Proper regulation of gene expression is essential for cell differentiation and homeostasis. Most of our understanding of the mechanisms that control the transcript...
Structure-Function Studies of Aquaporin 0 in Lens Development and Physiology
Project Summary Cataract, the opacification of the eye lens, is the leading cause of blindness worldwide. Aquaporin 0 (AQP0), the most abundant membrane protein in the lens, functi...
Global control of co-transcriptional splicing
Alternative splicing (AS) of human genes is pervasive and greatly expands the repertoire of protein and RNA products arising from the human genome. AS is critical for cellular diff...
Novel approaches for relating genetic variation in endogenous retroviruses to function and disease
PROJECT SUMMARY/ABSTRACT Genome-wide association studies (GWAS) for complex traits have often revealed a significant proportion of risk attributed to the non-coding genome. This ha...
The brain cholesterol interactome
Abstract Both serum cholesterol levels and the cholesterol carrying protein ApoE have been implicated in the development of Alzheimer’s disease. Despite intensive research, there i...
Circuits driving spatial coding deficits in epilepsy
Project Summary/Abstract Temporal lobe epilepsy (TLE) is a debilitating disorder that includes pervasive memory impairments that significantly impact quality of life. In rodent mod...
PrEP adherence-concentration thresholds associated with HIV protection among African women
ABSTRACT African women are disproportionately affected with HIV and have elevated risk of acquiring HIV in pregnancy. Pre-exposure prophylaxis (PrEP) is a potent HIV prevention str...