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99,167 grants found
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Role of cDC2 subsets in host protection and CD4T cell responses in melanoma
Project Summary Despite recent successes, many melanoma patients still fail to respond to immunotherapy and there is a pressing need for identifying novel therapeutic targets. The...
Mediators Of Arrested Differentiation In Pediatric Rhabdomyosarcoma
Project Summary/Abstract Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. Despite rigorous clinical trials the survival for children with high-risk RMS h...
Role of extracellular matrix proteins and tumor stroma in DNA repair and cancer progression
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDA) is the fourth lethal cancer in the U.S. with a 5-year survival rate of only ~10%. The mainstay of therapy in PDA is chemother...
A hybrid effectiveness-implementation trial of a school based executive function treatment for transition age youth with autism
PROJECT SUMMARY The proposed study is highly relevant to the 2017 Interagency Autism Coordinating Committee priorities to improve transition to adulthood in autism spectrum disorde...
Regulation of spore peptidoglycan modification
SUMMARY The bacterial pathogen, Clostridioides difficile, has been designated an urgent threat to the US healthcare system by the Centers for Disease Control. In order for C. diffi...
Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertension
Project Summary/Abstract Pulmonary arterial hypertension (PAH) is a highly morbid cardiopulmonary disease characterized by an obliterative vasculopathy involving distal pulmonary a...
Abbreviated Non-Contrast-Enhanced MRI for Breast Cancer Screening
Project Abstract Overview: In 2020, over 276,000 women will be diagnosed with invasive breast cancer, and over 48,000 will die from it. The ultimate goal of this project is to prov...
Imaging Modulation of Immune Phenotype
Imaging and modulation of immunophenotype Most importantly, we have created TLR delivery nanotherapeutics and find that TLR NPs combined with aCD40, aPD-1 and aCTL4 (abbreviated as...
Development of multifunctional drug and immune modulator delivery nanoparticles for the treatment of cancer patients with comorbid atherosclerosis
Project Summary Cancer and cardiovascular disease are leading causes of death in the United States. Given the high percentage of cancer patients with co-existing atherosclerosis, t...
Target Validation for I-BET151-Induced Differentiation in the African Trypanosome
PROJECT SUMMARY/ABSTRACT African trypanosomes are protozoan parasites that cause severe and often fatal disease in a variety of mammals in Sub-Saharan Africa, including humans (sle...
1/2 Identification and Validation of Expression Quantitative Trait Loci (eQTLs) in discrete cell types across human brain development
ABSTRACT Functional genomic analyses of the developing human brain have revealed highly dynamic spatiotemporal patterns of gene expression and epigenetic changes during prenatal an...
Structural Studies of Macromolecular Assemblies Using Cryo-EM
Project Summary/Abstract The main objective of the proposed studies is the elucidation of fundamental processes of translation, translational regulation and translational quality c...
Mitochondria targeting for Alzheimer's Disease
PROJECT SUMMARY Decreased energy metabolism is an invariant feature of the brains of Alzheimer’s disease (AD) patients, yet the specific use of pharmacologic strategies to manipula...
Phase II trial of GM-CSF/sargramostim in Alzheimer's Disease
PROJECT ABSTRACT Alzheimer’s disease (AD) treatments designed to target the amyloid-beta peptide have shown encouraging results in transgenic animal models but less encouraging res...
EncystR: A novel entry point for uncovering the regulation of encystation in Giardia
Project Summary Cyst formation is ubiquitous across the diversity of protists, yet its regulation is poorly understood in most species. Major morphological changes occur as the par...
Tunneling nanotubes as an alternate route of Ebola virus dissemination
Ebola virus (EBOV) is an emerging, dangerous virus that causes increasingly more frequent outbreaks of a systemic, hemorrhagic disease in human populations. Approved countermeasure...
A Single Ascending Dose / Multiple Ascending Dose Phase I study of the GSM 776890 in healthy normal subjects
Scientific Abstract AD is currently a huge health problem that imposes a severe social and economic burden; in the absence of an effective disease modifying treatment it is project...
Genomic Characterization of Alzheimer Disease Risk in Admixed Populations with Native American and Southern European Genetic Ancestry
ABSTRACT Alzheimer disease (AD) is the leading cause of dementia in older adults and occurs in all ethnic and racial groups. Genetic studies of AD have mostly been performed in non...
Language Development and Social Interaction in Children with Hearing Loss
Project SummaryThis project uses objectively measured, longitudinal data to capture the vocal interactions of children with hearing loss in order to understand everyday factors tha...
Development of a rapid, pan fungal diagnostic assay
ABSTRACT Diagnosing fungal infections faces a number of challenges including a decline in expertise needed for identifying fungi and a reduced number of instruments and assays spec...