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99,167 grants found
Showing 96,181 – 96,200 of 99,167 grants
Regulation of vascular metabolism in acute lung injury
Project Summary/Abstract The proposal outlines an integrated research and career development plan for David Wu, MD PhD, to com- plete postdoctoral training in the laboratories of G...
Relationship between Glaucoma and the Three-Dimensional Optic Nerve Head Related Structure
Project Summary Glaucoma is the second leading cause of blindness globally, and is characterized by optic nerve damage that leads to the death of retinal ganglion cells with accomp...
Systematic mapping and prediction of gene-enhancer connections
PROJECT SUMMARY The training program described in this supplement aims to bring diversity to NIH?s scientific workforce by supporting an underrepresented minority (URM) undergradua...
Mechanism Shaping the Adhesion Landscape During Spinal Cord Development
PROJECT SUMMARY An important question in developmental biology is how cell fate specification and cell movement are coordinated during tissue morphogenesis to ensure all cell types...
Deciphering the regulatory principles governing enhancer specificity
Abstract Enhancers are the genomic elements that encode the instructions for when and where genes are expressed during development. The majority of mutations leading to disease are...
Regulation of tendon formation by Ca2+ signaling through CaV1.2 L-type voltage-gated calcium channel
PROJECT SUMMARY Intracellular Ca2+ influences major tendon signaling pathways.Although Ca2+ signaling has been studied extensively for its roles in muscle contraction, immune cell...
Dopaminergic mechanisms underlying behavioral deficits following mild TBI
Almost 2.5 million people visit the emergency room each year in the United States as a consequence of sustaining a traumatic brain injury (TBI).Of these almost 75% are diagnosed wi...
TRP channels as fundamental sensors of the cerebral microcirculation
PROJECT SUMMARY Optimal flow of blood within the brain is ensured by two processes: (1) autoregulation, a collection of intrinsic mechanisms that continuously adjust the microcircu...
TRP channels as fundamental sensors of the cerebral microcirculation
PROJECT SUMMARY Optimal flow of blood within the brain is ensured by two processes: (1) autoregulation, a collection of intrinsic mechanisms that continuously adjust the microcircu...
Collaborative Research and Action: Empowering an Exposed Community
Project Summary/Abstract: The Michigan PBB Registry was established in order to study the health of thousands of people exposed to brominated flame retardants as a result of the la...
Role and regulation of PRX1 expressing cells during calvarial bone regeneration
Craniofacial surgeons and neurosurgeons perform numerous bone regeneration procedures to treat calvarial congenital abnormalities or lesions due to trauma and cancer.Current proced...
High-throughput screening for modulators of vascular fat transport to treat and prevent diabetes
PROJECT SUMMARY / ABSTRACT Insulin resistance (IR) in skeletal muscle and other tissues is obligatory for the development of type 2 diabetes.Excess accumulation of incompletely oxi...
Immunological characterization of rationally-designed vaccines against plague in mice and non-human primate models
ABSTRACT The increasing number of bubonic/pneumonic plague cases globally (2010-2018), including the U.S., with a ~18% case fatality rate may reflect climate changes and a rodent c...
Integrated Behavioral Activation and HIV Risk Reduction Counseling for MSM with Stimulant Abuse
Background: Problematic stimulant (i.e., crystal methamphetamine [meth], cocaine, crack) use is a prevalent and treatment refractory problem in men who have sex with men (MSM), and...
Recombination pathway and partner choices during meiosis
Research Summary Recombination between chromosomes is required to generate genetic variation, maintain genome integrity through the repair of double strand DNA breaks (DSBs), and e...
MOLECULAR AND CELLULAR CONTROL OF INJURY-INDUCED ASTROGENESIS
DESCRIPTION (provided by applicant): Despite recent advances in biomedical sciences, treatment options remain limited for patients suffering from stroke or other forms of brain inj...
Visual Form Perception Produced by Electrically Stimulating Human Visual Cortex
Project Summary/Abstract Blindness disables millions of people across the world.In most cases, incurable blindness is caused by damage or dysfunction of the eye, retina, or optic n...
Efficient estimation of auditory sensitivity and cognitive status using spoken-digit tests.
Project Summary/Abstract.Untreated age-related hearing loss (ARHL) is the most prevalent cause of reduced quality of life for persons 55 and older in the US. There are 30+ million...
The Circadian Molecular Clock is a Biomarker for Epilepsy in Focal Cortical Dysplasia
Abstract Focal epilepsy is the most common cause of epilepsy.The abnormal epileptogenic region of the brain that generates seizures or seizure focus is critically important because...
Exercise Dose and Metformin for Vascular Health in Adults with Metabolic Syndrome
PROJECT SUMMARY/ABSTRACT Arterial disease is the leading cause of morbidity/mortality in Metabolic syndrome (MetS). This occurs early as evidenced by arterial dysfunction that, in...