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99,167 grants found
Showing 96,161 – 96,180 of 99,167 grants
Role of Erbb3 kinase activity in colorectal tumorigenesis.
The overarching goals of this proposal are to determine if Erbb3 kinase plays a critical role in colorectal tumorigenesis and to test if colorectal cancer with oncogenic Erbb3 muta...
Multi-center observational study of the relationship of ventilation and outcomes from cardiac arrest using existing data
Project Summary/Abstract Introduction: Out-of-hospital cardiac arrest (OHCA) is a major public health problem that affects over 350,000 adults in the United States each year. Survi...
A Wearable Morning Light Treatment for Postpartum Depression: Confirming Efficacy and Mechanisms
ABSTRACT As one of the most common pregnancy complications, nearly 600,000 women in the United States suffer from postpartum depression annually. Consequences of postpartum depress...
Real-time visualization and precision targeting in transcranial magnetic stimulation
Project Summary Title: Real-time visualization and precision targeting in transcranial magnetic stimulation Transcranial magnetic stimulation (TMS) is a non-invasive device-based n...
Mapping of Novel Candidate Functional Elements with Bru-Seq Technology
Abstract The ENCODE project has provided a tremendous resource for scientists with a treasure trove of data from a large set of different cell types describing RNA expression (RNA-...
PRODUCTION CENTER FOR MAPPING REGULATORY REGIONS OF THE HUMAN GENOME
ABSTRACT Although our ability to determine the genome sequence of individuals is becoming facile, our understanding of the function of most of the human genome is limited.Mapping o...
Examining COVID-19 in Down Syndrome Patients Using Human iPSC-Derived Organoids
Project Summary Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has infected more than 20 million people worldwide as of August 2020 and significantly altered...
Drug abuse and HIV-associated pulmonary vascular injury
PROJECT SUMMARY University of Kansas Medical Center Research Institute, Inc. Advancement in antiretroviral therapy (ART) has clearly led to a serious increase in the prevalence of...
Understanding affective processing of scientific evidence to promote informed choice for breast cancer screening
Project Summary/Abstract Cancer screening for the right patients at the right level of cancer risk can save lives, but over the last several years many expert groups have de-intens...
Glioma therapy with oncolytic adenoviruses and immunometabolic adjuvants
SUMMARY / ABSTRACT With current treatment options, the five-year survival rate of patients with glioblastoma (GBM) is only 5%. Oncolytic viruses are promising treatments against so...
Defining the molecular basis of oncogene-induced replication stress
PROJECT SUMMARY/ABSTRACT Environmental genotoxic carcinogens target numerous proto-oncogenes (and tumor-suppressor genes) to induce point mutations in key codons, leading to oncoge...
Dementia with Lewy Bodies Consortium
Project Summary It has been estimated that 1.4 million people in the United States suffer from Lewy body dementia (LBD), including both dementia with Lewy bodies (DLB) or Parkinson...
Central Regulation of Sodium Appetite via Synergistic Action of RAAS-sensitive Neurons
PROJECT SUMMARY The motivation to consume sodium, often referred to as sodium (or salt) appetite, is a hard-wired neural response to sodium deficiency regulated by the Renin-Angiot...
The impact of dietary zinc deficiency on innate immunity to lung infection
PROJECT SUMMARY Candidate: My postdoctoral research thus far focused on the effects of host dietary zinc on bacterial pathogenesis during Acinetobacter baumannii pneumonia in Dr. E...
Capacity limits in the neural circuitry of visual word recognition
Project Summary / Abstract For most literate adults, reading feels effortless.However, visual word recognition is a complex process performed by specialized circuits in the brain,...
Osteosarcoma: Patient Derived Xenograft Preclinical Testing
Project Summary Not Applicable
Cellular mechanisms of antidepressant drug actions in neuropathic pain models
PROJECT SUMMARY Neuropathic pain is a chronic condition characterized by sensory, cognitive and affective symptoms. Most of the drugs used to treat this disorder demonstrate low ef...
Polyunsaturated fatty acids and colorectal tumor risk: a molecular and genetic epidemiology study
PROJECT SUMMARY/ABSTRACT Arachidonic acid, a long-chain ?-6 polyunsaturated fatty acid (PUFA), has been demonstrated to affect carcinogenesis in animal and in vitro studies.The eff...
Diversity Administrative Supplement to Maximizing Flexibility: Optimized Neural Probes and Electronics for Long Term, High Bandwidth Recordings
Project Summary No changes from original grant U01NS115588
CIRCADIAN PATTERN OF REST-ACTIVITY RHYTHMS AND BLOOD PRESSURE AND THE UNDERLYING
Project Summary: Nearly half of US adults present with HTN, one of the strongest risk factors for cardiovascular disease (CVD) and a leading cause of CVD mortality.Blood pressure (...