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99,167 grants found
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Unexpected Function of Inflammasomes in Axon Pruning: Focus on NLRP1
Project Summary/Abstract Neurons are capable of activating pathways that induce either the degeneration of the entire cell by apoptosis or to selectively degenerate only the axons....
Dopamine system as reporter of HIV status and inflammation in Meth abusers
2021 NIDA Summer Research Internship Program Systems Biology Approaches to identify Biological Processes associated with Genomic effects of Dopamine in HIV-infected Macrophages Abs...
Exploiting Unconventional Building Blocks in Chemical Synthesis
Project Summary/Abstract The central objective of this application is to harness unconventional synthetic building blocks for the development of new, reliable, and efficient, metho...
Targeting AR and AR-Variants in Castration-Resistant Prostate Cancer
Project Summary/Abstract Current AR inhibitors (enzalutamide and abiraterone) inhibit either the conversion of androgen to dihydrotestosterone (DHT), block androgen binding to andr...
The gut endoderm: origin, formation and fate
PROJECT SUMMARY / ABSTRACT The gut endoderm is the precursor tissue of the respiratory and digestive tracts, and their associated visceral organs.In this project we will use a suit...
Sleep in Neurocognitive Aging and Alzheimers Research (SANAR)
Latinos have up to a fourfold risk of Alzheimer's disease and related dementias (ADRD) compared to non- Hispanic whites. Further, ADRD onset occurs earlier in Latinos and is o...
Integrated Behavioral Activation and HIV Risk Reduction Counseling for MSM with Stimulant Abuse
PROJECT SUMMARY The purpose of this summer research internship is to expose the selected student intern to theories, methods, public health issues, and community-based research add...
Methods for Evolutionary Genomics Analysis
PROJECT SUMMARY This administrative supplement request aims to develop a cloud-enabled, highly scalable version of the computational core of the Molecular Evolutionary Genetics Ana...
MicroRNA as a target for fetal hemoglobin inducing agents in sickle cell disease
My long-term research goal is to develop effective pharmacological interventions that can alleviate disease progression and improve the quality of life for patients with sickle cel...
Harnessing multimodal data to enhance machine learning of children’s vocalizations
Project Summary This Administrative Supplement proposes implementation of a multimodal data pipeline to support machine learning of child language production in complex naturalisti...
Development of Poly (pro-curcumin) Polymer Coatings to Improve Cortical Electrode Biocompatibility
This application aims to create innovative polymer coatings to improve intracortical microelectrode biocompatibility.Following intracortical microelectrode implantation, an inflamm...
Role of cDC2 subsets in host protection and CD4T cell responses in melanoma
Project Summary Despite recent successes, many melanoma patients still fail to respond to immunotherapy and there is a pressing need for identifying novel therapeutic targets.The p...
Racial Bias in a VA Algorithm for High-Risk Veterans
PROJECT SUMMARY African-American Veterans are at particular risk of adverse outcomes, including mortality and hospitalization, due to adverse social determinants of health (SDoH) i...
EncystR: A novel entry point for uncovering the regulation of encystation in Giardia
Project Summary Cyst formation is ubiquitous across the diversity of protists, yet its regulation is poorly understood in most species.Major morphological changes occur as the para...
Montessori Approaches in Person-Centered Care (MAP-VA): An Effectiveness-Implementation Trial in Community Living Centers
Background: VA Community Living Center (CLC) staff struggle to address behavioral and neuropsychiatric symptoms of Veterans with dementia and serious mental illness (SMI) such as s...
Bromodomain-containing Protein 4 in Profibrotic Gene Expression and Lung Fibrosis
PROJECT SUMMARY Idiopathic pulmonary fibrosis (IPF) is a fatal lung disorder of unknown etiology. IPF is characterized by altered epigenetic state. Epigenetic alterations are poten...
Mitochondrial lateral transfer during metastasis
Project Summary Macrophages play paradoxical roles in cancer: They can be tumoricidal, but in many cancers, macrophages promote metastasis. There has been growing evidence that mac...
Targeting B7-H3 in ovarian cancer
ABSTRACT Remarkable clinical responses have been reported in B-cell malignancies by adoptive transfer of T cells redirected with a chimeric antigen receptor (CAR) specific for the...
Overcoming ibrutinib resistance in mantle cell lymphoma
Project Abstract Ibrutinib, a covalent inhibitor of Bruton tyrosine kinase (BTK) and similar inhibitors of B-cell receptor (BCR)- associated kinases are shifting the therapeutic la...
The role of PARP10 in alleviating replication stress and promoting cellular proliferation and tumorigenesis
Project Summary Identification of molecular pathways that are preferentially employed and relied upon by cancer cells compared to normal cells is key to designing novel personalize...