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Novel Story Recall Measures as Indicators of Cognitive Decline Associated with Alzheimer's Disease and Related Disorders Biomarkers: A Collaborative Study of Existing Data
PROJECT SUMMARY/ABSTRACT Growing advances in imaging and fluid-based assays of Alzheimer's disease (AD) biomarkers including amyloid, tau and neurodegeneration, confirm that A...
Imaging Genetics of Brain Structure and Cognitive Aging in Murine Models of Alzheimer's Disease
Age-related cognitive decline (ARCD), Alzheimer disease (AD), and late-onset AD-related pathologies are linked to changes in brain structure, cell populations, synapse densities an...
Neural Mechanisms of Vibroacoustically Augmented Breath Focused Mindfulness for Dissociative Traumatized People
Dissociation is a multifaceted, transdiagnostic, and disabling phenomenon that involves detachment from the self or surroundings.It is prevalent in traumatized people with posttrau...
Fortilin, CTNNA3, and the Heart
Project Summary The main goal of this grant proposal titled ?Fortilin, CTNNA3, and the Heart? is to test the central hypothesis that the inability of the failing heart to maintain...
Merging machine learning and mechanistic models to improve prediction and inference in emerging epidemics
PROJECT SUMMARY When an outbreak of an established or emerging infectious disease occurs we ask a standard set of questions that are critical to a lifesaving public health response...
Deciphering the molecular control of intratumoral dendritic cells
PROJECT SUMMARY Dendritic cells (DC) have a major influence on tumor immunity.DC depletion abrogates tumor immunity and response to PD1 (?PD1) immunotherapy in many preclinical tum...
Investigating Macrophage Molecular and Functional Diversity in Tumor Immunity
PROJECT SUMMARY Macrophages (MF) are one of the largest immune cell components of tumor lesions, where their numbers can even exceed cancer cells.MF play a key role in shaping the...
Cell-Type Specific Vulnerability to Tauopathy and Its Prevention in Multiple Models
Abstract The tau protein is a key hallmark of Alzheimer?s disease and other tauopathies but its pathogenesis is not well understood.Targeting its toxicity and/or aggregates with an...
Phase II trial of GM-CSF/sargramostim in Alzheimer's Disease
PROJECT ABSTRACT Alzheimer?s disease (AD) treatments designed to target the amyloid-beta peptide have shown encouraging results in transgenic animal models but less encouraging res...
Endothelial Instruction of Macrophage Fate in Inflammatory Injury
PROJECT SUMMARY/ABSTRACT There is an emerging recognition that the vasculature is not only a conduit for blood flow but actively modulates tissue inflammation and repair by interac...
Neutralizing the degenerate disc microenvironment to enhance the efficacy of therapeutic stem cells
Abstract Low back pain is the leading cause of disability in the United States, with an estimated socioeconomic cost exceeding $100 billion each year.Intervertebral disc degenerati...
Targeting AR and AR-Variants in Castration-Resistant Prostate Cancer
Project Summary/Abstract Current AR inhibitors (enzalutamide and abiraterone) inhibit either the conversion of androgen to dihydrotestosterone (DHT), block androgen binding to andr...
A Complete Metal Artifact Reduced MRI Exam for Neuroimaging
Project Summary Techniques for reducing metal artifacts in magnetic resonance imaging (MRI) of orthopaedic implants have seen tremendous improvement in the last decade. Extensions...
Spatiotemporal representation in ventral visual pathway
In natural vision, objects change appearance over time as they translate, rotate, become occluded or undergo complex transformations, e.g., during biological motion.In these dynami...
Cardiac Lineage-Specific Molecular Mechanisms of Heart Failure
Project Summary The heart consists of a multitude of diverse cardiac cell types, including but not limited to cardiomyocytes, cardiac fibroblasts, epicardial cells, endothelial/end...
B-cell innate and adaptive protective immunity to SARS-CoV-2
The COVID-19 caused by the SARS-CoV-2 coronavirus infection is currently a global pandemic.The most important question is why some individuals produce rapid protective antibodies (...
Discovering the role of YES1 in triple negative breast cancer
PROJECT SUMMARY/ABSTRACT SRC Family Kinases (SFKs) are a group of 9 non-receptor tyrosine kinases that mediate the effects of many extracellular and intracellular signaling pathway...
Gene Expression Regulatory Pathways and Retinal Ganglion Cell Neuroprotection
Loss of retinal ganglion cells (RGCs) in glaucoma and traumatic and other optic neuropathies results in permanent partial or complete blindness.Molecular mechanisms that may oppose...
PrEP adherence-concentration thresholds associated with HIV protection among African women
ABSTRACT African women are disproportionately affected with HIV and have elevated risk of acquiring HIV in pregnancy.Pre-exposure prophylaxis (PrEP) is a potent HIV prevention stra...
Mechanisms of exacerbation of COVID-19 pathogenesis in mice expressing human ACE2 by polycyclic aromatic hydrocarbons (PAHs), and its protection by inhibition of soluble epoxide hydrolase (sEH)
Project Summary Severe coronavirus disease (COVID-19) is caused by a novel Beta-coronavirus, now named SARS-CoV-2.COVID-19 is characterized by unresolved systemic hyperinflammation...