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99,167 grants found
Showing 96,081 – 96,100 of 99,167 grants
Muller cell activation and remodeling in AMD.
Age-related macular degeneration (AMD) is a complex, multifactorial disease. I have recently reported subretinal Müller cell membranes in areas of geographic atrophy (GA). These me...
Characterizing the primary olfactory subregions of the human amygdala
Several subregions of the human amygdala receive direct projections from the olfactory bulb, yet the functional and anatomical properties of these olfactory projections are not wel...
Circuits driving spatial coding deficits in epilepsy
Project Summary/Abstract Temporal lobe epilepsy (TLE) is a debilitating disorder that includes pervasive memory impairments that significantly impact quality of life.In rodent mode...
Targeting cholesterol metabolism and replication stress response in cancer therapy
Project Summary: Lung cancer is the leading cause of cancer deaths in both men and women.Non-small cell lung cancer (NSCLC) accounts for large majority of lung cancer diagnoses, an...
Effect of PDE5 Inhibition on Adipose Metabolism in Humans
ABSTRACT Obesity is characterized by an excess of white adipose tissue (WAT), which has low metabolic activity.Recent studies demonstrate that cells in WAT can be driven toward a m...
Subjective Cognitive Decline and Objective Cognitive Trajectories in Older Hispanics/Latinos
Project Summary/Abstract This project is directly aligned with the NIA?s strategic goals of 1) developing improved approaches for the early detection and diagnosis of disabling ill...
Impact of Loss-of-function NADPH Oxidase Variants on B cell Activation in SLE
Project abstract Genome-wide association studies (GWAS) have identified immune pathways linked to the pathogenesis of systemic lupus erythematosus (SLE).However, despite these insi...
Targeting MUC5AC mucin in breast cancer brain metastasis
Abstract Breast cancer (BC) brain/central nervous system (CNS) metastasis is associated with poor survival among U.S. women, with 30-40% of these cases reported as triple receptor-...
Neuronal Mechanisms of Metabolic and Genetic Defects of the Peroxisome
PROJECT SUMMARY Peroxisomes are fundamental sub-cellular organelles present in all eukaryotic cells.Peroxisomes participate in a number of biochemical pathways including catabolism...
Development of selective HDAC6 inhibitors to improve cancer immunotherapy
Project Summary The median survival for metastatic melanoma is approximately 8?16 months, and few therapies offer a significant improvement in overall survival.However, immunothera...
Structure-Function Studies of Aquaporin 0 in Lens Development and Physiology
Project Summary Cataract, the opacification of the eye lens, is the leading cause of blindness worldwide.Aquaporin 0 (AQP0), the most abundant membrane protein in the lens, functio...
Overcoming ibrutinib resistance in mantle cell lymphoma
Project Abstract Ibrutinib, a covalent inhibitor of Bruton tyrosine kinase (BTK) and similar inhibitors of B-cell receptor (BCR)- associated kinases are shifting the therapeutic la...
Abbreviated Non-Contrast-Enhanced MRI for Breast Cancer Screening
Project Abstract Overview: In 2020, over 276,000 women will be diagnosed with invasive breast cancer, and over 48,000 will die from it.The ultimate goal of this project is to provi...
Overcoming the blood-brain barrier with nanoparticle vaccines against gliomas
Project Summary While activated T cells cross the blood-brain barrier (BBB), immunotherapy has yet to be harnessed for targeted therapy due to GBM?s heterogeneity and immunosuppres...
High-sensitivity Immunomagnetic System for "Liquid Biopsy" of Alzheimer's Disease
Project Summary Alzheimer?s disease (AD) is a major healthcare and social-economic burden.With effective treatment yet to be developed, the early detection at the prodromal stage a...
Unraveling the role of HLA-B51/ERAP1 in Behcet’s eye disease
ABSTRACT / PROJECT SUMMARY HLA-B*51 in epistasis with the ERAP1 haplotype Hap10 confers the strongest currently known risk for Behcet?s Disease (BD) and Behcet?s Eye Disease (BED),...
Targeting immunosuppressive adenosine in patients with metastatic non-small cell lung cancer
SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed the management of patients with metastatic non-small cell lung cancer (NSCLC). Unfortunately, over 50% of pati...
Language Development and Social Interaction in Children with Hearing Loss
Project Summary This project uses objectively measured, longitudinal data to capture the vocal interactions of children with hearing loss in order to understand everyday factors th...
The role of obscurin and Obsl1 as key determinants for diastolic function
Project Summary: The role of obscurin and Obsl1 as key determinants for diastolic function Cardiovascular disease (CVD) remains a leading cause of mortality in the US, with heart f...
Imaging brain iron and protein aggregation with MRI for assessing Alzheimer's disease pathology and progression
Abstract Alzheimer?s disease (AD) affects over 5 million Americans and is expected to affect 2-3-fold more in the next few decades. AD is associated with aggregation of amyloid-bet...