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99,167 grants found
Showing 96,061 – 96,080 of 99,167 grants
Secondary data analysis of auditory steady-state response to explore the RDoC cognitive system constructs across the psychosis spectrum
Hallucinations and cognitive impairments associated with psychosis may be underpinned by N-methyl D- aspartate (NMDA) receptor hypofunction.Within the Research Domain Criteria (RDo...
Dental Follicle: A Central Regulator of Tooth Root Formation and Regeneration
PROJECT SUMMARY/ABSTRACT The tooth root is a critical component of the tooth, anchored to surrounding alveolar bones through the periodontal ligament (PDL).Appropriate formation of...
Replication stress response defects predict and enhance immune checkpoint therapy response in triple negative breast cancer
Project Summary The lack of specific targets for the treatment of triple-negative breast cancer (TNBC) is a major challenge, as many TNBCs do not respond to cytotoxic chemotherapie...
Global control of co-transcriptional splicing
Alternative splicing (AS) of human genes is pervasive and greatly expands the repertoire of protein and RNA products arising from the human genome.AS is critical for cellular diffe...
Spatial and nonspatial knowledge
Project Summary The ability to navigate from one place to another is essential for a flourishing and autonomous human life.Cognitive scientists have long believed that navigation i...
The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis
ABSTRACT Recently there has been compelling evidence that inflammatory bowel disease (IBD) subjects, both Crohn's disease (CD) and Ulcerative Colitis (UC), commonly have disru...
Mobile Ecological Momentary Diet Assessment: A Low Burden, Ecologically-Valid Approach to Measuring Dietary Intake in Near-Real Time
ABSTRACT The excessive intake of saturated fat and added sugars has been identified as a leading cause of premature mortality among adults in the U.S. contributing to approximately...
Defining the molecular basis of oncogene-induced replication stress
PROJECT SUMMARY/ABSTRACT Environmental genotoxic carcinogens target numerous proto-oncogenes (and tumor-suppressor genes) to induce point mutations in key codons, leading to oncoge...
Delineating mechanisms of skeletal fragility in older adults with Type 1 Diabetes
PROJECT SUMMARY / ABSTRACT Skeletal fragility is a recently recognized complication of Type 1 diabetes (T1D), and is of particular concern among older adults. Patients with T1D hav...
Point-of-care HPV mRNA test for cervical cancer screening in low-resource settings
Abstract: There is a significant need to improve global access to cervical cancer screening. Globally, approximately 570,000 women are diagnosed with and 311,000 women die from cer...
Transcriptional Regulation of Lung Alveolar Regeneration
ABSTRACT The respiratory system is comprised of multiple unique and spatially distinct compartments that respond to injury and diseases states differently based on their cellular a...
Mitochondrial lateral transfer during metastasis
Project Summary Macrophages play paradoxical roles in cancer: They can be tumoricidal, but in many cancers, macrophages promote metastasis.There has been growing evidence that macr...
The contributions of interaurally correlated signals and interaurally symmetric place of stimulation for the binaural auditory system
PROJECT SUMMARY / ABSTRACT Binaural hearing provides substantial benefits in complex listening environments, improving the ability to understand speech and providing the ability to...
Bayesian Network-Based Integrative Genomics Methods for Precision Medicine
Project Summary/Abstract Modern multi-platform genomic data sets contain substantial molecular information potentially useful for discovering new precision therapeutic strategies.I...
Studies of Allostery between Multi-domain Proteins and Nucleic Acid Complexes
Project Summary The PI Batista from Yale and co-investigators (Lisi, Brown University, and Palermo, UC Riverside) will investigate allosteric pathways in the CRISPR-Cas9 system ? c...
Energy Balance, mTOR pathway signaling, and breast cancer prognosis
Project Summary/Abstract The objective of this project is to understand the role of the mechanistic Target of Rapamycin (mTOR) pathway in the association between energy imbalance a...
Bromodomain-containing Protein 4 in Profibrotic Gene Expression and Lung Fibrosis
PROJECT SUMMARY Idiopathic pulmonary fibrosis (IPF) is a fatal lung disorder of unknown etiology. IPF is characterized by altered epigenetic state. Epigenetic alterations are poten...
Effects of aging on signal in noise processing
PROJECT SUMMARY/ABSTRACT Age-related hearing loss is a ubiquitous problem, estimated to affect up to one third of the population.This condition is much more detrimental than ?hard...
Targeting tumor architecture as a novel therapeutic strategy for pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most chemorefractory cancers among solid tumors. Even with the most effective chemotherapy (i.e., FOLFIRINOX), only 30% of PDA...
Control of Commitment Steps in Mammalian Homologous Recombination
Project Summary: ?Control of Commitment Steps in Mammalian Homologous Recombination?The appearance of many cancer cases, especially breast, ovarian, and pancreatic cancer, is linke...