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99,167 grants found
Showing 96,021 – 96,040 of 99,167 grants
Structure-guided and high-throughput engineering of genetically encoded sensors for reactive oxygen species
Modified Project Summary/Abstract Section Elevated levels of reactive oxygen species (ROS) are strongly linked to severe pathological conditions causing cardiomyopathies and neurod...
TRPV4 Regulates Mechanosensitive Macrophage Functions in Lung Injury
PROJECT SUMMARY/ABSTRACT Overwhelming bacterial pneumonia injures and stiffens the lung leading to acute respiratory distress syndrome (ARDS) that carries a mortality of up to 50%....
Structure, Mechanism and Interactions of Type IA Topoisomerases
Project Summary/Abstract Type IA topoisomerases are ubiquitous in the three kingdoms of life, and play critically important roles in maintaining proper DNA topology during the vita...
Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertension
Project Summary/Abstract Pulmonary arterial hypertension (PAH) is a highly morbid cardiopulmonary disease characterized by an obliterative vasculopathy involving distal pulmonary a...
Harnessing multiplexed Cas9 genome editing for sequential genetic manipulations and recording activities in cell lineages
SUMMARY Time is a problem for biologists, especially for those interested in cancer, stem cell, and developmental biology.Whereas cellular processes occur in real time, we most oft...
Glutamatergic basal forebrain neurons in aversion-resistant drinking
Project Summary A hallmark of alcohol use disorder is continued seeking and consumption of alcohol despite negative consequences.Neuroadaptations in corticostriatal projections to...
Identifying mechanisms and reversibility of eosinophil-induced airway hyperinnervation in asthma
Asthma is characterized by excessive bronchoconstriction and a heightened sensitivity to inhaled irritants. Airway nerves control these responses.Recently, we found that eosinophil...
Mesenchymal modulation of epithelial metaplasia in lung fibrosis
Project Summary/Abstract Aberrant epithelial reprogramming can take the form of metaplasia, characterized by the appearance of mature cell types that are not normally present at th...
Regulation of spore peptidoglycan modification
SUMMARY The bacterial pathogen, Clostridioides difficile, has been designated an urgent threat to the US healthcare system by the Centers for Disease Control.In order for C. diffic...
Continuous Therapeutic Drug Monitoring of Antibiotics in CRRT
Summary Aptamers are oligonucleotide-based receptors that can be isolated from the large libraries of random oligonucleotides to bind to small molecules.In the past, our team devel...
Characterizing the Complexity of Advanced Cancer Pain in the Home Context by Leveraging Smart Health Technology
Project Summary Cancer pain is complex, prevalent and has serious consequences for patients, family caregivers and healthcare systems. Inadequately managed cancer pain can be parti...
Deep tensor genomic imputation
Project Summary/Abstract High-throughput sequencing assays allow scientists to measure biochemical properties like transcription factor binding, histone modi?cations, and gene expr...
Trans-omic analysis of epicardial adipose tissue in atrial fibrillation
Project Summary Atrial fibrillation (AF) is the most common arrhythmia affecting well over 2 million people in the US with projections that it will affect 8-12 million people by 20...
The role and mechanism of necrosis in glioblastoma
Project Summary Gliomas are major primary brain tumors, of which glioblastomas (GBM) are the most common and aggressive forms.The poor outcome of traditional treatment for these tu...
Understanding affective processing of scientific evidence to promote informed choice for breast cancer screening
Project Summary/Abstract Cancer screening for the right patients at the right level of cancer risk can save lives, but over the last several years many expert groups have de-intens...
Cognitive training to reduce incidence of cognitive impairment in older adults
PROJECT SUMMARY Dementia is the most expensive medical condition in the US. There is an urgent need to intervene to curb the increasing prevalence of dementia in our population.Str...
Biophysical Characterization of Subthalamic Local Field Potentials in Parkinson's Disease
PROJECT SUMMARY Subthalamic deep brain stimulation (DBS) can significantly improve the motor symptoms and quality of life of patients with Parkinson?s disease (PD).Recent advances...
The role of CELF2 and its genetic variants in Alzheimer's disease
Age is the most important risk factor for Alzheimer's disease (AD), but the occurrence of this disease is also affected by environmental factors, individual experience and gen...
Molecular and neural mechanisms of predator cue sensation
Understanding how animals make behavioral decisions is one of the biggest problems in neuroscience.The proposed study aims to understand molecular and neural mechanisms underlying...
Sleep-dependent modulation of cerebrospinal fluid flow in aging and across genetic risk for Alzheimers disease
Project Abstract Sleep is essential for brain health, and neurodegenerative diseases are associated with substantial sleep disruptions.Disrupted sleep is now thought to not just be...