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The interplay of ion transporters and cytoskeleton in breast cancer migration and metastasis
The inability to clinically treat tumor metastasis is responsible for the majority of cancer patient deaths. Cell migration is a pivotal step in the metastatic dissemination of can...
The impact of enculturation on the epigenetic relationship between chronic stress and hypertension in Yup'ik Alaska Native people
Project Summary The objective of the proposed research is to identify molecular mechanisms linking the protective role of culture to blood pressure regulation, a major risk factor...
IL-27-producing B cells in the antibody response
PROJECT SUMMARY – IL-27-producing B cells in the antibody response Built on our novel findings that B cells can be induced to express high levels of IL-27 (IL27p28/EBI3 heterodimer...
Epidemiology and Impact of the HIV, NCD, and Urbanization Syndemic in Africa
Africa bears the vast majority (69%) of the world’s current HIV infections with 26 million persons living with HIV (PLHIV). Increased access to antiretroviral therapy (ART) in Afri...
The interplay of ion transporters and cytoskeleton in breast cancer migration and metastasis
The inability to clinically treat tumor metastasis is responsible for the majority of cancer patient deaths. Cell migration is a pivotal step in the metastatic dissemination of can...
Dietary influence on infant growth and the gut microbiota
The overall objective of this project is to establish how infant diet with different protein-rich foods regulate growth trajectories and gut microbiota development.Both NIH and USD...
The interplay of ion transporters and cytoskeleton in breast cancer migration and metastasis
The inability to clinically treat tumor metastasis is responsible for the majority of cancer patient deaths. Cell migration is a pivotal step in the metastatic dissemination of can...
SMART NANPs: new molecular platform for communication with human immune system and modulation of therapeutic responses
Principal Investigator/Program Director (Last, First, Middle): Afonin, Kirill, A PROJECT SUMMARY What if healthcare providers were equipped with biocompatible, biodegradable, robus...
Exploiting Unconventional Building Blocks in Chemical Synthesis
Project Summary/Abstract The central objective of this application is to harness unconventional synthetic building blocks for the development of new, reliable, and efficient, metho...
Mitotic transmission of acentric chromosome fragments
The goal of this proposal is to elucidate the molecular and cellular basis of a newly discovered diverse set of adaptive mechanisms that maintain the integrity of the genome during...
The Effect of Screening and Referral for Social Determinants of Health on Veterans' Outcomes
Background: Despite medical advances, up to 70% of health outcomes are due to social determinants of health (SDoH) - the conditions in which people live and work that shape whether...
1/2 Identification and Validation of Expression Quantitative Trait Loci (eQTLs) in discrete cell types across human brain development
ABSTRACT Functional genomic analyses of the developing human brain have revealed highly dynamic spatiotemporal patterns of gene expression and epigenetic changes during prenatal an...
Targeting Integrins in Lung Cancer
Lung cancer is the most common cause of cancer-related deaths in US veterans and worldwide.Molecularly targeted therapy and immunotherapy are two recent major breakthroughs in lung...
Contra-Thermodynamic Catalysis and Fluorine Sculpting; Two Counter Cultural Approaches to Synthesis
Project Summary/Abstract The objectives of this proposal are two-fold and include the development and conceptual advancement of contra- thermodynamic catalysis and fluorine sculpti...
Molecular mechanisms of the mitochondrial permeability transition
The overarching goal of my research program is to identify and characterize molecular mechanisms responsible for stress-induced permeabilization of the mitochondrial inner membrane...
Stimulation of Ribosomal Frameshifting by Cotranslational Membrane Protein Folding and Misfolding
ABSTRACT The proteostasis network relies on numerous feedback mechanisms to strike a balance between the rates of protein synthesis and degradation, which is crucial for the mainte...
Peer Coaching for Physical Activity Promotion among Breast Cancer Survivors: Adapting an Efficacious Intervention to Prepare for Implementation
Interventions promoting physical activity among cancer survivors improve their functioning, reduce fatigue and offer other benefits in cancer recovery and risk reduction for future...
Linkage of s100a10 (p11) to enteric 5-HT4-mediated serotonergic signaling roles in GI motility, enteric nervous system development, and co-morbid dysfunction of gut and brain
Project Summary Although functional gastrointestinal (GI) disorders (FGIDs) are the most common causes of bowel dysfunction worldwide, many patients are inadequately treated becaus...
TRP channels as fundamental sensors of the cerebral microcirculation
PROJECT SUMMARY Optimal flow of blood within the brain is ensured by two processes: (1) autoregulation, a collection of intrinsic mechanisms that continuously adjust the microcircu...
Identifying low dose measurement error corrected effects of multiple pollutants using causal modeling
The Global Burden of Disease estimates that ambient air pollution is responsible for over 4 million deaths per year, yet regulators in the US, EU, India, and China have been reluct...