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99,167 grants found
Showing 941 – 960 of 99,167 grants
Validation of neuronal senescence as a target for chronic pain in aging
Project Summary Aging is a major risk factor for the development of chronic pain with 50% of adults over the age of 65 suffering from at least one chronic pain condition. Unfortuna...
Expanding the capabilities and usage of the TELSAM protein crystallization chaperone
There is a critical need for new protein crystallization methods that are more successful and require less labor, time, and resources. Lack of straightforward methods to successful...
Clinical Effectiveness of Exercise After an Implantable Cardioverter Defibrillator (ICD)
Abstract The goal of this study is to test the effectiveness and describe implementation of a home based exercise intervention for persons with an implantable cardioverter defibril...
Promoting Health Aging through Semantic Enrichment of Solitude Research (PHASES)
Research on solitude often highlights the risks of spending time alone with a focus on negative outcomes, such as mortality and depression. When positive outcomes are associated wi...
Foundational Investigations into Bacterial Surface Glycan Dynamics
Project Abstract Bacteria have existed for millions of years and have evolved sophisticated methods of communication. One primary mechanism is through the glycans on their surface,...
Breathing Easier in Schools: Enhancing Adoption, Fidelity, and Effectiveness of the SAFE School Program through Innovation Implementation Strategies
PROJECT SUMMARY Asthma contributes to chronic absenteeism and learning loss in U.S. school children and respiratory distress is the leading cause of 9-1-1 calls from schools. When...
Expanding the Scope and Usability of Fast Voltammetric Measurements
ABSTRACT: Background-subtracted fast-scan cyclic voltammetry (FSCV) is unrivaled in its ability to monitor neurochemical dynamics. This approach permits highly localized analysis o...
6/7 PsycheMERGE: Advancing Precision Psychiatry
PROJECT SUMMARY Psychiatric disorders remain a leading cause of disability in the US and are associated with increased morbidity and mortality. Early detection and treatment is ess...
Opioid actions on the habenulo-peduncular circuit
PROJECT SUMMARY Withdrawal is a major obstacle in overcoming opioid dependence and addiction. Identifying the neural circuits involved and how opioids modulate the activity of thos...
Social cognition in AUD recovery: Understanding trajectories, consequences, and mechanisms of change for deficits in emotion processing
Project Summary Alcohol Use Disorder (AUD) is characterized by attenuated capacities to recognize and interpret the emotional states of others. Extant cross-sectional studies have...
Interplay Between Langerhans Cells and Sensory Neurons: Impact on Wound Healing and Nociception Following Burn Injuries
PROJECT SUMMARY Effective wound care is of paramount importance for individuals who have sustained burn injuries. Wound healing is intricately associated with the sensations of itc...
Post-stroke Cognitive Impairment and Dementia
Vascular contributions to cognitive impairment and dementia are increasingly recognized as independent causes of dementia, particularly due to their high prevalence and potential f...
The function of post-translational modifications of myosin and its chaperone UNC-45 that occur with adult aging
Project Summary One of the unfortunate effects of aging is the loss of muscle mass, strength, and function, termed “sarcopenia”, when it is not associated with an underlying diseas...
Individualizing Approaches to Surveillance Mammography in Older Breast Cancer Survivors
PROJECT SUMMARY/ABSTRACT Evidence-based approaches to surveillance mammography for older breast cancer survivors do not exist. Data suggest a life expectancy of ~10-years is necess...
The physiological and molecular function of choline transport in health and metabolic disease
Project Summary Nutrient homeostasis in most living cells is mediated by membrane carrier proteins, which facilitate the translocation of small molecule metabolites across cellular...
Activation of deep crypt secretory cells in colonic inflammation
PROJECT SUMMARY An impaired epithelial lining is a key pathological element of numerous diseases of the colon; however, our understanding of how specific epithelial cell population...
The ADHINCRA Study: Addressing HypertensIoN Care in AfRicA
Project Summary/Abstract Innovation in chronic disease management is urgently needed to effectively control hypertension (HTN) in Ghana and Nigeria. Both countries are suffering si...
Comprehensive Molecular and Clinical Characterization of Acute and Chronic Neurotoxicity Following CAR-T Cell Therapy
PROJECT SUMMARY Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of hematologic malignancies, resulting in remarkable disease response rates. Yet, the u...
Targeting dysfunctional epithelial repair in pulmonary fibrosis
While it is generally agreed that epithelial injury is a central process in Idiopathic Pulmonary Fibrosis (IPF), differential mechanisms that determine functional repair versus dys...
Cardiovascular Effects of Inhalable Tobacco Product Dual Use
PROJECT SUMMARY The introduction of e-cigarettes (e-cigs) was portrayed by the tobacco industry, and expected by the public, to result in an alternative to smoking cigarettes that...