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99,167 grants found
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Urine and serum biomarkers for early diagnosis and risk assessment of pancreatic cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, primarily due to most cases being diagnosed at an advanced, incurable stage. While 5-year surviv...
Mechanisms of cGAMP export
Project Summary/Abstract The cGAS-cGAMP-STING DNA sensing pathway has emerged as a key innate immune response that is important for antiviral immunity, contributes to autoimmune di...
Targeting polymicrobial infections of diabetic foot ulcers with a novel antimicrobial peptide therapy
SUMMARY Diabetic foot ulcers (DFUs) are non-healing chronic wounds that develop upon skin injury in patients with poorly controlled diabetes mellitus (DM). One quarter of DM pati...
Host factors required for vancomycin resistance in enterococci
PROJECT SUMMARY The continued and inevitable emergence of antibiotic resistance demands a vigorous and sustained effort to identify fundamentally new targets and strategies for inn...
Imaging and Molecular Phenotyping of Cystic Fibrosis Lung Disease
Cystic fibrosis (CF) is among the most common fatal genetic diseases in the U.S. and involves progressive lung function loss and structural remodeling, leading to lung transplant o...
Urine and serum biomarkers for early diagnosis and risk assessment of pancreatic cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, primarily due to most cases being diagnosed at an advanced, incurable stage. While 5-year surviv...
Inhibition of EGF Receptor Prevents and Reverses Non-Alcoholic Fatty Liver Disease
ABSTRACT In the last two decades, there has been an increased appreciation of a long-term threat, that of non-alcoholic fatty liver disease (NAFLD), evolving into non-alcoholic ste...
Advancing skin cancer prevention by tackling UV-induced clonogenic mutations
1 Squamous cell skin cancer (SCC) is the second most common cancer in the US. There are methods available 2 to prevent SCC but are not appropriately used because we lack methods of...
De-implementation of Mammography Overuse in Older Racially and Ethnically Diverse Women
PROJECT SUMMARY De-implementation is recognized as a critical but understudied area within implementation science (IS). Research is needed to determine the optimal methods and appr...
Determinants of Palliative Care Effectiveness for Patients with Metastatic Cancer
Project Summary Palliative care is an interdisciplinary model of care with the overarching goal of improving quality of life for patients with serious illness through symptom manag...
Inhibition of EGF Receptor Prevents and Reverses Non-Alcoholic Fatty Liver Disease
ABSTRACT In the last two decades, there has been an increased appreciation of a long-term threat, that of non-alcoholic fatty liver disease (NAFLD), evolving into non-alcoholic ste...
Urine and serum biomarkers for early diagnosis and risk assessment of pancreatic cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, primarily due to most cases being diagnosed at an advanced, incurable stage. While 5-year surviv...
Determinants of Palliative Care Effectiveness for Patients with Metastatic Cancer
Project Summary Palliative care is an interdisciplinary model of care with the overarching goal of improving quality of life for patients with serious illness through symptom manag...
Advancing skin cancer prevention by tackling UV-induced clonogenic mutations
1 Squamous cell skin cancer (SCC) is the second most common cancer in the US. There are methods available 2 to prevent SCC but are not appropriately used because we lack methods of...
De-implementation of Mammography Overuse in Older Racially and Ethnically Diverse Women
PROJECT SUMMARY De-implementation is recognized as a critical but understudied area within implementation science (IS). Research is needed to determine the optimal methods and appr...
Imaging and Molecular Phenotyping of Cystic Fibrosis Lung Disease
Cystic fibrosis (CF) is among the most common fatal genetic diseases in the U.S. and involves progressive lung function loss and structural remodeling, leading to lung transplant o...
The impact of enculturation on the epigenetic relationship between chronic stress and hypertension in Yup'ik Alaska Native people
Project Summary The objective of the proposed research is to identify molecular mechanisms linking the protective role of culture to blood pressure regulation, a major risk factor...
Epigenetic and Metabolic Regulation of Gene Silencing in Saccharomyces
This application for a MIRA award seeks to consolidate the research in the PI's lab, funded by GM31105 Genetic Analysis of Genes Controlling a Position Effect, currently in it...
Dietary influence on infant growth and the gut microbiota
The overall objective of this project is to establish how infant diet with different protein-rich foods regulate growth trajectories and gut microbiota development.Both NIH and USD...
The interplay of ion transporters and cytoskeleton in breast cancer migration and metastasis
The inability to clinically treat tumor metastasis is responsible for the majority of cancer patient deaths.Cell migration is a pivotal step in the metastatic dissemination of canc...