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99,167 grants found
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Integration of genetic, gene expression and environmental data to inform biological basis of mammographic density
ABSTRACT Given its strong association with breast cancer, mammographic density has been proposed as a surrogate endpoint for breast cancer. We have previously conducted genome-wide...
Eliciting neutralizing antibodies and B cell responses using novel HIV Env immunogens in non-human primates
Neutralizing antibodies are likely to be required for an effective HIV-1 vaccine. However, few candidate vaccines efficiently elicit broadly neutralizing antibodies (bNAbs) followi...
Precision mapping of regulatory causal variants by expression CROPseq
ABSTRACT Genetic differences among individuals ultimately trace to single nucleotide polymorphisms, the majority of which affect traits, including disease susceptibility, by influe...
Eliciting neutralizing antibodies and B cell responses using novel HIV Env immunogens in non-human primates
PROJECT SUMMARY A broadly effective HIV vaccine remains a high priority to reduce the spread of this highly pathogenic virus in the human population. Neutralizing antibodies, broad...
Advancing skin cancer prevention by tackling UV-induced clonogenic mutations
1 Squamous cell skin cancer (SCC) is the second most common cancer in the US.There are methods available 2 to prevent SCC but are not appropriately used because we lack methods of...
De-implementation of Mammography Overuse in Older Racially and Ethnically Diverse Women
PROJECT SUMMARY De-implementation is recognized as a critical but understudied area within implementation science (IS).Research is needed to determine the optimal methods and appro...
Inhibition of EGF Receptor Prevents and Reverses Non-Alcoholic Fatty Liver Disease
ABSTRACT In the last two decades, there has been an increased appreciation of a long-term threat, that of non-alcoholic fatty liver disease (NAFLD), evolving into non-alcoholic ste...
Imaging and Molecular Phenotyping of Cystic Fibrosis Lung Disease
Cystic fibrosis (CF) is among the most common fatal genetic diseases in the U.S. and involves progressive lung function loss and structural remodeling, leading to lung transplant o...
Determinants of Palliative Care Effectiveness for Patients with Metastatic Cancer
Project Summary Palliative care is an interdisciplinary model of care with the overarching goal of improving quality of life for patients with serious illness through symptom manag...
Urine and serum biomarkers for early diagnosis and risk assessment of pancreatic cancer
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, primarily due to most cases being diagnosed at an advanced, incurable stage. While 5-year surviv...
Mechanisms of cGAMP export
Project Summary/Abstract The cGAS-cGAMP-STING DNA sensing pathway has emerged as a key innate immune response that is important for antiviral immunity, contributes to autoimmune di...
Characterizing Candida auris skin colonization and high-burden biofilm formation
PROJECT SUMMARY The emerging fungal pathogen Candida auris resides on skin and spreads rapidly person-to-person in healthcare settings, a trait unique to this species.C. auris skin...
Host factors required for vancomycin resistance in enterococci
PROJECT SUMMARY The continued and inevitable emergence of antibiotic resistance demands a vigorous and sustained effort to identify fundamentally new targets and strategies for inn...
Targeting polymicrobial infections of diabetic foot ulcers with a novel antimicrobial peptide therapy
SUMMARY Diabetic foot ulcers (DFUs) are non-healing chronic wounds that develop upon skin injury in patients with poorly controlled diabetes mellitus (DM). One quarter of DM pati...
Inhibition of EGF Receptor Prevents and Reverses Non-Alcoholic Fatty Liver Disease
ABSTRACT In the last two decades, there has been an increased appreciation of a long-term threat, that of non-alcoholic fatty liver disease (NAFLD), evolving into non-alcoholic ste...
Characterizing Candida auris skin colonization and high-burden biofilm formation
PROJECT SUMMARY The emerging fungal pathogen Candida auris resides on skin and spreads rapidly person-to-person in healthcare settings, a trait unique to this species. C. auris ski...
Advancing skin cancer prevention by tackling UV-induced clonogenic mutations
1 Squamous cell skin cancer (SCC) is the second most common cancer in the US. There are methods available 2 to prevent SCC but are not appropriately used because we lack methods of...
De-implementation of Mammography Overuse in Older Racially and Ethnically Diverse Women
PROJECT SUMMARY De-implementation is recognized as a critical but understudied area within implementation science (IS). Research is needed to determine the optimal methods and appr...
Imaging and Molecular Phenotyping of Cystic Fibrosis Lung Disease
Cystic fibrosis (CF) is among the most common fatal genetic diseases in the U.S. and involves progressive lung function loss and structural remodeling, leading to lung transplant o...
Determinants of Palliative Care Effectiveness for Patients with Metastatic Cancer
Project Summary Palliative care is an interdisciplinary model of care with the overarching goal of improving quality of life for patients with serious illness through symptom manag...