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99,167 grants found
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Investigation of the mechanisms and effects of riboregulation of iron homeostasis in M. tuberculosis
Summary Tuberculosis (TB) is a significant public health problem worldwide.Although the number of deaths due to TB has decreased in recent years thanks to improved diagnostics and...
Effect of Covid-19 on chronic kidney disease progression
Project Summary Coronavirus disease 2019 (COVID-19) is a respiratory illness that has sickened over 7 million people worldwide and continues to rapidly spread.The causal virus, sev...
Role of NadD in Mycobacterium tuberculosis proteostasis
Summary The goal of this research program is to characterize the biology of NadD (nicotinate adenylyltransferase) from Mycbobacterium tuberculosis (Mtb), the etiological agent of t...
Progesterone induced immune modulation during pregnancy – supplemental research in COVID-19
Project Summary: Despite pandemic spread of the novel coronavirus, COVID-19, significant knowledge gaps remain especially for Center for Disease Control designated high risk popula...
Broad spectrum Shigella subunit vaccine based on conserved proteins
ABSTRACT Shigella spp. are a major global cause of diarrhea and dysentery. Children 2-5-years of age in low- and middle- income countries are the most affected.Mortality is second...
Bone Marrow Niche dysfunction in sickle cell disease
SUMMARY/ABSTRACT Background.Sickle cell disease (SCD) is the most common form of inherited blood disorder affecting approximately 100,000 Americans.Patients with SCD suffer from re...
Eliciting neutralizing antibodies and B cell responses using novel HIV Env immunogens in non-human primates
Neutralizing antibodies are likely to be required for an effective HIV-1 vaccine. However, few candidate vaccines efficiently elicit broadly neutralizing antibodies (bNAbs) followi...
Admin Core
The Administrative Core A, led by Dr. Richard Wyatt, will administer support for Projects 1 and 2 and Cores B and C, under the umbrella of this new HIVRAD proposal. This Core will...
Core B_Silvestri
Nonhuman primates (NHP) specifically, rhesus macaques (RMs), are a key animal model in investigating prevention strategies of HIV infection. This animal model of simian immunodefic...
Core C_Ward
Abstract Structure-based vaccine design holds great promise for combatting viral pathogens that create substantial burdens on global health. For HIV, the soluble ectodomain of the...
Project 1
The elicitation of cross-neutralizing or broadly neutralizing Abs (bNAbs) to diverse HIV strains by Env vaccination remains a high priority for a broadly efficacious vaccine. The e...
Project 2_Nilla
Summary Circulating (tier 2) HIV-1 variants are highly resistant to antibody-mediated neutralization, making broadly effective vaccine design a major challenge. Encouragingly, work...
Broad spectrum Shigella subunit vaccine based on conserved proteins
ABSTRACT Shigella spp. are a major global cause of diarrhea and dysentery. Children 2-5-years of age in low- and middle- income countries are the most affected. Mortality is second...
Biologically informed design of CD8+ T cell-dependent pre-erythrocytic stage malaria vaccines
PROJECT SUMMARY/ABSTRACT Immunization with whole pre-erythrocytic (sporozoite and liver stage) Plasmodium falciparum (Pf) vaccines confers sterilizing immunity in human clinical tr...
Precision mapping of regulatory causal variants by expression CROPseq
ABSTRACT Genetic differences among individuals ultimately trace to single nucleotide polymorphisms, the majority of which affect traits, including disease susceptibility, by influe...
Multiscale modeling of an inductive hair follicle microenvironment in engineered skin substitute
Engineered skin tissues must reproduce the biological and mechanical functions of their native counterparts if they are to provide health benefits to society. However, engineered s...
Three-model platform for understanding DMD epigenetic mechanisms and advancing small molecule therapies
PROJECT SUMMARY Duchenne muscular dystrophy (DMD) is a severe degenerative muscle disease caused by mutations in the DMD gene, which encodes dystrophin. The current standard of car...
Electroconvulsive therapy amplitude titration for improved clinical outcomes in late-life depression
Electroconvulsive therapy (ECT) stimulation parameter selection reflects a balance between efficacy and cognitive adverse effects. ECT stimulation parameters associated with more a...
Integration of genetic, gene expression and environmental data to inform biological basis of mammographic density
ABSTRACT Given its strong association with breast cancer, mammographic density has been proposed as a surrogate endpoint for breast cancer. We have previously conducted genome-wide...
Effect of Covid-19 on chronic kidney disease progression
Project Summary Coronavirus disease 2019 (COVID-19) is a respiratory illness that has sickened over 7 million people worldwide and continues to rapidly spread. The causal virus, se...