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Vascular Targeting of Nanocarriers for RNA
Clinical approval of Lipid Nano Particles (LNP) for RNA heralded the advent of nanotechnology- based pharmacotherapy. Yet, RNA delivery to extra-hepatic sites remains a major unmet...
Comprehensive molecular characterization of endometrial cancer, etiologic heterogeneity, and racial disparities
ABSTRACT Endometrial cancer (EC) is the most common gynecologic cancer in the US. Incidence is increasing, especially for aggressive, understudied tumors that confer poor prognosis...
Prevalence, onset and progression of substance use in adolescents and young adults with Autism Spectrum Disorders
Project Summary Alcohol use and alcohol use disorders (AUD) in adolescents and young adults with autism spectrum disorders (ASD) have been considered rare by mental health professi...
HPV16 E6 Antibody Detection as an Early Marker for Oropharyngeal Cancer Among Men Living with HIV
People living with HIV (PLWH) have an increased life expectancy due to effective therapies. This has resulted in an increased incidence of non-AIDS defining cancers (NADCs), in par...
Adolescent health at the intersections of sexual, gender, racial/ethnic, immigrant identities and native language
Project Abstract Sexual and gender minority (SGM) adolescents are at disproportionate risk of poor health behaviors, experiences and outcomes compared to their straight, cisgender...
Molecular Imaging CCR2 Lung Inflammation and Fibrosis
SUMMARY Pulmonary fibrosis is the result of a poorly understood, dysregulated cellular response that is difficult to diagnose and treat. A common form, idiopathic pulmonary fibrosi...
Investigating Immune-Microbiome interactions during treatment of Clostridioides difficile with fecal microbiome transplantation
Project Summary Hospitalized patients receiving antibiotic treatment experience a disruption in the intestinal microbiome enabling opportunistic pathogens, such as Clostridioides d...
Biologically informed design of CD8+ T cell-dependent pre-erythrocytic stage malaria vaccines
PROJECT SUMMARY/ABSTRACT Immunization with whole pre-erythrocytic (sporozoite and liver stage) Plasmodium falciparum (Pf) vaccines confers sterilizing immunity in human clinical tr...
Precision mapping of regulatory causal variants by expression CROPseq
ABSTRACT Genetic differences among individuals ultimately trace to single nucleotide polymorphisms, the majority of which affect traits, including disease susceptibility, by influe...
Electroconvulsive therapy amplitude titration for improved clinical outcomes in late-life depression
Electroconvulsive therapy (ECT) stimulation parameter selection reflects a balance between efficacy and cognitive adverse effects.ECT stimulation parameters associated with more an...
Integration of genetic, gene expression and environmental data to inform biological basis of mammographic density
ABSTRACT Given its strong association with breast cancer, mammographic density has been proposed as a surrogate endpoint for breast cancer.We have previously conducted genome-wide...
Three-model platform for understanding DMD epigenetic mechanisms and advancing small molecule therapies
PROJECT SUMMARY Duchenne muscular dystrophy (DMD) is a severe degenerative muscle disease caused by mutations in the DMD gene, which encodes dystrophin.The current standard of care...
Multiscale modeling of an inductive hair follicle microenvironment in engineered skin substitute
Engineered skin tissues must reproduce the biological and mechanical functions of their native counterparts if they are to provide health benefits to society.However, engineered sk...
Eliciting neutralizing antibodies and B cell responses using novel HIV Env immunogens in non-human primates
Neutralizing antibodies are likely to be required for an effective HIV-1 vaccine. However, few candidate vaccines efficiently elicit broadly neutralizing antibodies (bNAbs) followi...
Admin Core
The Administrative Core A, led by Dr.Richard Wyatt, will administer support for Projects 1 and 2 and Cores B and C, under the umbrella of this new HIVRAD proposal.This Core will co...
Core B_Silvestri
Nonhuman primates (NHP) specifically, rhesus macaques (RMs), are a key animal model in investigating prevention strategies of HIV infection.This animal model of simian immunodefici...
Core C_Ward
Abstract Structure-based vaccine design holds great promise for combatting viral pathogens that create substantial burdens on global health.For HIV, the soluble ectodomain of the e...
Project 1
The elicitation of cross-neutralizing or broadly neutralizing Abs (bNAbs) to diverse HIV strains by Env vaccination remains a high priority for a broadly efficacious vaccine.The el...
Project 2_Nilla
Summary Circulating (tier 2) HIV-1 variants are highly resistant to antibody-mediated neutralization, making broadly effective vaccine design a major challenge.Encouragingly, work...
Optimization of anesthetic/sedative regimen for pulmonary pathophysiology in cystic fibrosis patients
Project Summary The median age for survival of cystic fibrosis (CF) patients is still in the mid 40s and pulmonary deterioration is the major cause of mortality for CF patients.Bec...