Browse All Grants
99,167 grants found
Showing 95,841 – 95,860 of 99,167 grants
Regulation of inner ear development by FGF signals and effectors
Morphogenesis of the inner ear epithelium requires coordinated deployment of several signaling pathways and disruptions cause abnormalities of hearing and/or balance. With the adve...
Vascular Targeting of Nanocarriers for RNA
Clinical approval of Lipid Nano Particles (LNP) for RNA heralded the advent of nanotechnology- based pharmacotherapy. Yet, RNA delivery to extra-hepatic sites remains a major unmet...
Molecular Imaging CCR2 Lung Inflammation and Fibrosis
SUMMARY Pulmonary fibrosis is the result of a poorly understood, dysregulated cellular response that is difficult to diagnose and treat. A common form, idiopathic pulmonary fibrosi...
A Female-Specific Cognitive Behavioral Therapy Group for Alcohol Use Disorder in VA Primary Care Settings
Project Summary: Women comprise 10% of the U.S. Veteran population, expected to rise to 35% by 2035.1, 2 37% of female Veterans report risky or problem alcohol use4, and many have...
Mechanisms of differentiation blockade in CSF3R-mutant AML
PROJECT SUMMARY Acute Myeloid Leukemia (AML) is a lethal blood cancer, with a 5-year survival rate of only 25%. One driver of especially poor prognosis in AML is mutation of Colony...
Increasing nerve-sparing radical prostatectomy rates using intraoperative nonlinear microscopy
Prostate cancer is the most common cancer in the US male population, with an estimated 160,000 new cases in 2018. Treatment with radical prostatectomy (RP), complete surgical excis...
Comprehensive molecular characterization of endometrial cancer, etiologic heterogeneity, and racial disparities
ABSTRACT Endometrial cancer (EC) is the most common gynecologic cancer in the US. Incidence is increasing, especially for aggressive, understudied tumors that confer poor prognosis...
Focal delivery of nitro-oleic acid using ultrasound targeted microbubble cavitation for the treatment of microvascular obstruction
With the introduction of reperfusion therapy, mortality from AMI has decreased markedly, from 20% in 1980 to 5% in 2008, but has plateaued despite the fact that our time to reperfu...
Investigating Immune-Microbiome interactions during treatment of Clostridioides difficile with fecal microbiome transplantation
Project Summary Hospitalized patients receiving antibiotic treatment experience a disruption in the intestinal microbiome enabling opportunistic pathogens, such as Clostridioides d...
Evaluating STI screening and antimicrobial resistance in Neisseria gonorrhoeae among PrEP users in Vietnam
PROJECT ABSTRACT Men who have sex with men (MSM) are at higher risk for HIV and sexually transmitted infections (STIs) that increase HIV risk, such as Neisseria gonorrhoeae and Chl...
Cholesterol oxidation products in TB pathogenesis and as biomarkers of disease
SUMMARY Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB), killing more people than any other pathogen. Mtb is able to subvert innate immunity, impairing the antimicrobial...
Overcoming immune checkpoint inhibition with therapeutic plasma exchange and radiotherapy in melanoma
ABSTRACT PD-1-directed immune checkpoint inhibitors (ICI) have significantly improved survival in metastatic melanoma compared to traditional chemotherapy. Unfortunately, less than...
A chromosome-level genome assembly for the major African malaria vector Anopheles gambiae
Project Summary/Abstract The African malaria mosquito Anopheles gambiae, because of its epidemiological importance, was the first disease vector, with a genome sequenced in 2002. S...
HPV16 E6 Antibody Detection as an Early Marker for Oropharyngeal Cancer Among Men Living with HIV
People living with HIV (PLWH) have an increased life expectancy due to effective therapies. This has resulted in an increased incidence of non-AIDS defining cancers (NADCs), in par...
Molecular Imaging CCR2 Lung Inflammation and Fibrosis
SUMMARY Pulmonary fibrosis is the result of a poorly understood, dysregulated cellular response that is difficult to diagnose and treat. A common form, idiopathic pulmonary fibrosi...
Increasing nerve-sparing radical prostatectomy rates using intraoperative nonlinear microscopy
Prostate cancer is the most common cancer in the US male population, with an estimated 160,000 new cases in 2018. Treatment with radical prostatectomy (RP), complete surgical excis...
Investigating Immune-Microbiome interactions during treatment of Clostridioides difficile with fecal microbiome transplantation
Project Summary Hospitalized patients receiving antibiotic treatment experience a disruption in the intestinal microbiome enabling opportunistic pathogens, such as Clostridioides d...
Mechanisms of differentiation blockade in CSF3R-mutant AML
PROJECT SUMMARY Acute Myeloid Leukemia (AML) is a lethal blood cancer, with a 5-year survival rate of only 25%. One driver of especially poor prognosis in AML is mutation of Colony...
The Gut Microbiota in Metabolic Surgery: A Multi-Ethnic, Multi-Omic, Longitudinal Study
PROJECT SUMMARY Metabolic and bariatric surgery is an emerging option to treat obesity-related metabolic diseases, e.g., type 2 diabetes, and prevent atherosclerotic cardiovascular...
Adolescent health at the intersections of sexual, gender, racial/ethnic, immigrant identities and native language
Project Abstract Sexual and gender minority (SGM) adolescents are at disproportionate risk of poor health behaviors, experiences and outcomes compared to their straight, cisgender...