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99,167 grants found
Showing 95,821 – 95,840 of 99,167 grants
Behavioral economic and wellness-based approaches for reducing alcohol use and consequences among diverse non-student emerging adults
Brief alcohol interventions (BAI) are among the most cost-effective preventive care measures available and the evaluation of these interventions with high-risk and difficult-to-rea...
The contribution of novel cytidine deaminase regulatory systems to bacterial evolution
Project Summary: The current and 7th pandemic of Vibrio cholerae caused by the El Tor biotype encodes two novel genetic islands called the Vibrio Seventh Pandemic Islands 1 and 2 (...
Investigating Immune-Microbiome interactions during treatment of Clostridioides difficile with fecal microbiome transplantation
Project Summary Hospitalized patients receiving antibiotic treatment experience a disruption in the intestinal microbiome enabling opportunistic pathogens, such as Clostridioides d...
Overcoming immune checkpoint inhibition with therapeutic plasma exchange and radiotherapy in melanoma
ABSTRACT PD-1-directed immune checkpoint inhibitors (ICI) have significantly improved survival in metastatic melanoma compared to traditional chemotherapy. Unfortunately, less than...
A chromosome-level genome assembly for the major African malaria vector Anopheles gambiae
Project Summary/Abstract The African malaria mosquito Anopheles gambiae, because of its epidemiological importance, was the first disease vector, with a genome sequenced in 2002.Si...
Cholesterol oxidation products in TB pathogenesis and as biomarkers of disease
SUMMARY Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB), killing more people than any other pathogen. Mtb is able to subvert innate immunity, impairing the antimicrobial...
Novel Molecular Mechanisms Promote GPCR-Induced Bronchodilation in Asthma
Project Summary Our renewal of this interdisciplinary PPG remains focused on the theme of novel molecular mechanisms to inhibit human airway smooth muscle (HASM) contraction and pr...
MicroRNAs, ER Stress and Arsenic Neurotoxicity
ABSTRACT Exposure to arsenic (As) is a serious public health concern, contributing to a myriad of diseases including cancer, cardiovascular disease, diabetes, respiratory disease,...
Evaluating STI screening and antimicrobial resistance in Neisseria gonorrhoeae among PrEP users in Vietnam
PROJECT ABSTRACT Men who have sex with men (MSM) are at higher risk for HIV and sexually transmitted infections (STIs) that increase HIV risk, such as Neisseria gonorrhoeae and Chl...
HPV16 E6 Antibody Detection as an Early Marker of Oropharyngeal Cancer Among Men Living with HIV
Project Summary/Abstract People living with HIV (PLWH) have an increased life expectancy due to effective therapies.This has resulted in an increased incidence of non-AIDS defining...
Adolescent health at the intersections of sexual, gender, racial/ethnic, immigrant identities and native language: a supplementary study of HIV/AIDS preventive behaviors
Project Summary Sexual and gender minority (SGM) populations, including adolescents, are at disproportionate risk of HIV/AIDS infection compared to their straight, cisgender peers....
Lung-Protective Mechanisms of Metformin in TB
PROJECT SUMMARY Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health threat. Challenges of compliance and toxicities of prolonged antimicrob...
Prevalence, onset and progression of substance use in adolescents and young adults with Autism Spectrum Disorders
Project Summary Alcohol use and alcohol use disorders (AUD) in adolescents and young adults with autism spectrum disorders (ASD) have been considered rare by mental health professi...
Behavioral economic and wellness-based approaches for reducing alcohol use and consequences among diverse non-student emerging adults
Brief alcohol interventions (BAI) are among the most cost-effective preventive care measures available and the evaluation of these interventions with high-risk and difficult-to-rea...
The contribution of novel cytidine deaminase regulatory systems to bacterial evolution
Project Summary: The current and 7th pandemic of Vibrio cholerae caused by the El Tor biotype encodes two novel genetic islands called the Vibrio Seventh Pandemic Islands 1 and 2 (...
The Gut Microbiota in Metabolic Surgery: A Multi-Ethnic, Multi-Omic, Longitudinal Study
PROJECT SUMMARY Metabolic and bariatric surgery is an emerging option to treat obesity-related metabolic diseases, e.g., type 2 diabetes, and prevent atherosclerotic cardiovascular...
Role of Birth on Microvasculature Development in Striated MuscleRole of Birth on Microvasculature Development in Striated Muscle
The heart and the skeletal muscle are similar types of muscle, and when they are not perfused with enough blood through their capillaries, they experience similar problems, includi...
MicroRNAs, ER Stress and Arsenic Neurotoxicity
ABSTRACT Exposure to arsenic (As) is a serious public health concern, contributing to a myriad of diseases including cancer, cardiovascular disease, diabetes, respiratory disease,...
Patient-derived organoids reveal rectal cancers develop radiosensitivity
The Fearon and Vogelstein multistep cancer progression model of colon cancer defines key genetic changes associated with progression from normal colorectal tissue to early/late ade...
Adolescent health at the intersections of sexual, gender, racial/ethnic, immigrant identities and native language
Project Abstract Sexual and gender minority (SGM) adolescents are at disproportionate risk of poor health behaviors, experiences and outcomes compared to their straight, cisgender...