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99,167 grants found
Showing 95,801 – 95,820 of 99,167 grants
Pro-Drug Enolase Inhibitors in Precision Oncology
ABSTRACT. Genomic deletions of major tumor suppressor genes are frequent events in cancer yet presently remain therapeutically unactionable for the purpose of precision oncology. O...
Anti-inflammatory functions for non-transcriptional IRF3
Project Summary/Abstract The innate immune response is the first line of defense against microbial infection.Virus infection causes rapid induction of interferon (IFN) and IFN-indu...
Regulation of Voltage-gated Proton Channel
Abstract The voltage-gated Hv1 proton channel is a member of voltage-gated ion channel family, it plays a key role in the acid extrusion from excitable and non-excitable cells and...
Intracellular complement activation in Lupus Nephritis Podocytes
Project Summary Deposition of immune complexes and activation of the complement system mediates glomerular injury and is involved in the inflammatory process in patients with lupus...
Mechanisms and Treatment of Cardiac and Skeletal Muscular Dysfunction in Barth Syndrome
PROJECT SUMMARY Barth syndrome (BTHS) is a rare, frequently fatal, mitochondrial disease caused by recessive loss-of-function mutations in the gene TAZ, which encodes tafazzin.Tafa...
Intracellular complement activation in Lupus Nephritis Podocytes
Project Summary Deposition of immune complexes and activation of the complement system mediates glomerular injury and is involved in the inflammatory process in patients with lupus...
Mechanisms and Treatment of Cardiac and Skeletal Muscular Dysfunction in Barth Syndrome
PROJECT SUMMARY Barth syndrome (BTHS) is a rare, frequently fatal, mitochondrial disease caused by recessive loss-of-function mutations in the gene TAZ, which encodes tafazzin. Taf...
The Gut Microbiota in Metabolic Surgery: A Multi-Ethnic, Multi-Omic, Longitudinal Study
PROJECT SUMMARY Metabolic and bariatric surgery is an emerging option to treat obesity-related metabolic diseases, e.g., type 2 diabetes, and prevent atherosclerotic cardiovascular...
Vascular Targeting of Nanocarriers for RNA
Clinical approval of Lipid Nano Particles (LNP) for RNA heralded the advent of nanotechnology- based pharmacotherapy. Yet, RNA delivery to extra-hepatic sites remains a major unmet...
Adolescent health at the intersections of sexual, gender, racial/ethnic, immigrant identities and native language
Project Abstract Sexual and gender minority (SGM) adolescents are at disproportionate risk of poor health behaviors, experiences and outcomes compared to their straight, cisgender...
A Female-Specific Cognitive Behavioral Therapy Group for Alcohol Use Disorder in VA Primary Care Settings
Project Summary: Women comprise 10% of the U.S.Veteran population, expected to rise to 35% by 2035.1, 2 37% of female Veterans report risky or problem alcohol use4, and many have c...
Mechanisms of differentiation blockade in CSF3R-mutant AML
PROJECT SUMMARY Acute Myeloid Leukemia (AML) is a lethal blood cancer, with a 5-year survival rate of only 25%. One driver of especially poor prognosis in AML is mutation of Colony...
Lung-Protective Mechanisms of Metformin in TB
PROJECT SUMMARY Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health threat.Challenges of compliance and toxicities of prolonged antimicrobi...
Increasing nerve-sparing radical prostatectomy rates using intraoperative nonlinear microscopy
Prostate cancer is the most common cancer in the US male population, with an estimated 160,000 new cases in 2018.Treatment with radical prostatectomy (RP), complete surgical excisi...
Molecular Imaging CCR2 Lung Inflammation and Fibrosis
SUMMARY Pulmonary fibrosis is the result of a poorly understood, dysregulated cellular response that is difficult to diagnose and treat. A common form, idiopathic pulmonary fibrosi...
Role of Birth on Microvasculature Development in Striated MuscleRole of Birth on Microvasculature Development in Striated Muscle
The heart and the skeletal muscle are similar types of muscle, and when they are not perfused with enough blood through their capillaries, they experience similar problems, includi...
Focal delivery of nitro-oleic acid using ultrasound targeted microbubble cavitation for the treatment of microvascular obstruction
With the introduction of reperfusion therapy, mortality from AMI has decreased markedly, from 20% in 1980 to 5% in 2008, but has plateaued despite the fact that our time to reperfu...
HPV16 E6 Antibody Detection as an Early Marker for Oropharyngeal Cancer Among Men Living with HIV
People living with HIV (PLWH) have an increased life expectancy due to effective therapies.This has resulted in an increased incidence of non-AIDS defining cancers (NADCs), in part...
Prevalence, onset and progression of substance use in adolescents and young adults with Autism Spectrum Disorders
Project Summary Alcohol use and alcohol use disorders (AUD) in adolescents and young adults with autism spectrum disorders (ASD) have been considered rare by mental health professi...
Comprehensive molecular characterization of endometrial cancer, etiologic heterogeneity, and racial disparities
ABSTRACT Endometrial cancer (EC) is the most common gynecologic cancer in the US.Incidence is increasing, especially for aggressive, understudied tumors that confer poor prognosis...