Browse All Grants
99,167 grants found
Showing 881 – 900 of 99,167 grants
Investigation of active kinome networks in Alzheimer's dementia.
Summary This is a revised R01 application from a team of established investigators who bring complementary expertise for a multi-omics, hypothesis generating, series of experiments...
Development of Biotherapeutic Nanogels for Alzheimers Disease Treatment
Development of Biotherapeutic Nanogels for Alzheimer’s Disease Treatment. PROJECT SUMMARY (ABSTRACT): Alzheimer's disease (AD) is a neurodegenerative disease that has affected...
Telerehabilitation In The Home After Stroke: A Randomized, Controlled, Assessor-Blind Clinical Trial (The TR-2 Trial)
Project SummaryHigh doses of intensive rehabilitation therapy improve functional outcomes after stroke, but most patients do not receive this, for reasons that include limited acce...
Turning back biological clock: mechanisms of age reversal in a whole organism
ABSTRACT Reversing the negative effects of aging has the potential to delay age-related diseases and significantly improve the quality of life in old age. In recent findings, we re...
The Circadian Clock Coordinates Animal and Microbial Metabolism
Project Summary Our circadian clocks synchronize physiological processes and behaviors like eating and sleeping to environmental light cycles. The central clock located in the brai...
Unraveling Fundamental Mechanisms of Interorgan Crosstalk in Osteoarthritis
PROJECT SUMMARY Osteoarthritis (OA), the loss of cartilage lining articular joints, is the leading cause of pain and disability worldwide. There are no existing treatments for OA a...
Genomic recording systems to reveal evolutionary modifications in primate neocortex
Project Summary/Abstract Primate brains develop following an exquisitely conserved Bauplan that is shared with other mammals, yet also possess advanced cognitive capabilities. Thes...
Uncovering cellular and molecular adaptations for whole-organism rejuvenation
PROJECT SUMMARY Organismal aging and age-associated diseases, including many cancers, are driven by the slow accumulation of damage in cells and tissues over time. In some instance...
A spatial view of hematopoietic regeneration dynamics in the bone marrow
Project Summary: The regeneration of blood and immune cells relies on hematopoietic stem and progenitor cells (HSPCs) that reside in the bone marrow. HSPCs not only sustain homeost...
A community-based adaptation of a peer-led intervention to address alcohol use and HIV risk in pregnant women in South Africa (Mentor Moms+)
PROJECT SUMMARY The syndemic of alcohol use and HIV risk in pregnant and lactating people (PLP) threatens the health of mother, fetus, children and families in South Africa. PLP li...
Bridge to Belonging (B2B): Peer led intervention to reduce loneliness and depression among older gay and bisexual men
PROJECT SUMMARY Older gay and bisexual men living with HIV (OGBMLH) are twice as likely to experience depression compared to heterosexual and HIV-negative counterparts. Depression...
A National Survey on Naloxone Use and Access
ABSTRACT Improving naloxone access is a central pillar of the policy landscape to curb rising overdose deaths rates in the United States. In particular, improving access among “lay...
HIV viral suppression and prevention of postpartum weight retention in South Africa: A pilot trial
PROJECT SUMMARY/ABSTRACT Availability of antiretroviral therapy (ART) coverage to pregnant women for life through Option B+ has been a major advance in sub-Saharan Africa for mater...
opioid receptor activation of the carotid body mitigates OIRD by fentanyl
ABSTRACT Fentanyl is a widely used opioid in the clinic for relieving chronic pain. Fentanyl abuse leads to mortality due to opioid-induced respiratory depression (OIRD). OIRD is a...
Mapping the landscape of the aged human brain for neurodegenerative disease models
Summary Aging is the main contributor to many human neurodegenerative diseases, such as Alzheimer’s disease (AD), that are common, progressive, and have limited therapeutic options...
Team science approach to integrate machine-learning models and functional genomics to study aging in the context of Alzheimer's disease
PROJECT SUMMARY Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by progressive cognitive decline and dementia. It accounts for approximately...
Connecting Neuronal Hyperexcitability and Sex Differences in Alzheimer's Disease (AD) using biophysically-informed in-silico brain simulations and experimental data from mouse models of AD
The mechanism underlying neuronal hyperexcitability, as a result of excitation-inhibition (E-I) imbalance, leading to cognitive deterioration in Alzheimer’s disease (AD) is not ful...
Social Modifiers of Primate Lifespan
Social Modifiers of Primate Lifespan People who are socially isolated or low socioeconomic status suffer from poorer health and shorter lives. Social factors also impact the surviv...
Multiscale Modeling of Brain Aging and Alzheimer’s Disease with MRI, Pathology and Proteomics
Project Summary Aging has a pronounced effect on the human brain, yet differences between individuals can be substantial, and are likely influenced by genetic, environmental lifest...
The pathogenic effects of senescent cells on their microenvironments and their role in human brain aging
PROJECT SUMMARY Senescent cells were hypothesized to contribute to development of Alzheimer’s Disease and Related Dementias (ADRD) by secreting inflammatory factors in their surrou...