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99,167 grants found
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Gut clearance regulation and its subversion by Candida albicans
The CDC reports that fungal infections are responsible for ~9 million outpatient visits, ~75,000 hospitalizations and an estimated direct medical cost of ~$7 billion yearly. These...
Cardiovascular Risk Reduction for Adults with Food Insecurity Using Structured Incentives (CVD-FIT)
ABSTRACT Cardiovascular disease (CVD) is associated with significant morbidity and mortality, decreased quality of life, and increased health care utilization and cost. Food insecu...
Mechanisms underlying reversal of cardiac aging by urolithin a treatment
PROJECT SUMMARY/ABSTRACT Aging is one of the greatest risk factors for the development of cardiovascular disease and heart failure. Mitochondrial dysfunction in the aging heart is...
Using opioid industry documents to understand marketing of addictive medications
ABSTRACT Prescription opioids have been a key driver of the US opioid crisis, resulting in nearly 500,000 overdose deaths from 1999 to 2019. The US has the highest rate of per capi...
Investigating reciprocal interactions between circuit and synaptic function
PROJECT SUMMARY/ABSTRACT The patterns of connectivity across the neural networks of the brain play a critical role in determining how those networks function. However, the mechanis...
Sex-dependent aging mechanisms of retina and visual cortex
PROJECT SUMMARY: Aging induces changes in the visual system, including decreased visual acuity, contrast and wavelength sensitivity, and processing of visual information. These cha...
Aging and Health in a Changing Climate
PROJECT SUMMARY Older adults are particularly vulnerable to health impacts from climate-related events such as heat waves, hurricanes, wildfires, and floods. These impacts include...
APOE Genotype Mediated Effects on Alzheimer Disease Risk and Mechanisms
ABSTRACT The APOE ɛ2 and ɛ4 alleles are by far the strongest and most well-established common genetic risk factors for Alzheimer disease (AD). The deleterious effect of ɛ4 on AD ri...
IL-6 Trans-signaling increases vulnerability to Postoperative Cognitive Decline in Aging and Alzheimers Disease
Abstract Surgical patients expect to return to their pre-morbid state after the procedure for their underlying condition; unfortunately, perioperative neurocognitive disorders (PND...
Improving intestinal symptoms in a Congenital Disorder of Glycosylation
PROJECT SUMMARY/ ABSTRACT Congenital disorders of glycosylation are multi-system inherited diseases, which affect the amount of glycosylation added to proteins. For patients with m...
Generational Overlap: Changing Demography, Shared Lifetimes, and Family Resources
Project Summary/Abstract Kinship ties form the bedrock of societies and provide meaning in terms of roles, obligations, and responsi- bilities. Generational overlap in the form of...
Effect of Cognitive Empathy Training on Dementia Caregivers
Project Summary An estimated 5.8 million Americans age 65 and older are living with Alzheimer’s dementia in 2020. The majority of these individuals are cared for at home by family...
Personal Values in Dementia Experience, Caregiving, and Research
PROJECT SUMMARY/ABSTRACT Dementia caregivers, clinicians, and researchers can experience deep ethical conflicts when people with dementia express strong preferences about personal...
A new diagnostic test for AD based on a neurotoxic Abeta Dimer
Alzheimer’s Disease (AD) is a progressive neurodegenerative disease and future treatments are likely to be most effective in early stages, prior to the onset of dementia. The first...
Vascular Imaging Biomarker Relationships to Alzheimer’s disease (VIBRA)
PROJECT SUMMARY / ABSTRACT Improving vascular health is a potential strategy to delay the onset of Alzheimer's disease (AD) and related dementias (ADRD). The overlap of cerebr...
Air pollution, the blood and brain metabolome and their effects on Alzheimer's disease and related dementias
Abstract Exposures to ambient air pollution, especially fine particulate matter (PM2.5), have been associated with increased risks of many chronic illnesses, including Alzheimer’s...
Preparing Assisted Living Staff to Care for Persons with Dementia: Palliative Care Education in Assisted Living for Dementia Care Providers
PROJECT SUMMARY/ABSTRACT More than one-third of the one million older adults living in assisted living (AL) communities in the United States have a diagnosis of Alzheimer's di...
Understanding Ambulatory Care Utilization in Alzheimer's Disease and Related Dementias (ACUA)
Dementia is a disease characterized by a loss of memory and other cognitive functions that is severe enough to interfere with daily living. In 2023, an estimated 6.7 million Americ...
The cGMP-signaling axis in intestinal aging.
Along with the aging of our population comes important socioeconomic costs due to the numerous healthcare concerns of the elderly. Changes in the aging gastrointestinal tract under...
Substance of Change: Evaluation of Web-Based Training for Mentors and Staff Serving Youth Impacted by Substance Misuse
“Substance of Change: Evaluation of Web-Based Training for Mentors and Staff Serving Youth Impacted by Substance Misuse” Approximately 1.6 million youth between the ages of 12-17-y...