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The Role of Biological Sex in the Self-renewal of B1 Cells into Old Age in Mice and Humans
Project Summary/Abstract By the year 2050 the WHO predicts there will be 2 billion people aged 60-years and over. As the population of aged individuals rises so will aging-associat...
Improving measurement of cancer registry completeness
PROJECT SUMMARY Surveillance for cancer incidence and mortality is crucial to cancer control and cancer research. Cancer registries are the basis for allocating public health resou...
Evaluating the disease modifying properties of dimethyl fumarate (DMF) for the prevention and treatment of pharmacoresistant epilepsy
ABSTRACT Progressive decline in seizure control and cognitive function, coupled with anxiety and depression are often consequences of epilepsy that negatively impact a patient’s ov...
Integrating genetic and circuit variation to identify genes involved in behaviors related to substance use disorder
PROJECT SUMMARY The goal of this proposal is to identify genes that affect behaviors associated with substance use disorders (SUD) using a novel mechanism-to-gene strategy. Standar...
Partnering with Pregnant and Postpartum People to Co-Create a Novel Intervention to Reduce Tobacco and Cannabis Use
1R01DA057946-01A1Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Prenatal tobacco use among non-...
Basolateral amygdala dopamine in addiction-related learning strategies
Project Summary Environmental stimuli (“cues” – sensory information such as sights, sounds, and smells) help organize reward seeking and decision making. In disease states like add...
Regulating dopamine transport through allosteric modulation - Functional and Behavioral Studies
The plasma-membrane monoamine transporters (MATs), including the serotonin (SERT), norepinephrine (NET) and dopamine (DAT) transporters, serve a pivotal role in limiting monoamine-...
An open road driving performance task to examine long-term medical marijuana use and prescription opioid positivity in adults 50 and older
PROJECT SUMMARY Medical marijuana is legal in 37 states and the District of Columbia, and use among adults 50 and older has more than doubled in the past decade, with exponential i...
Depot formulations for on-demand tamper- and diversion-proof delivery of opioids
Summary Opioids are commonly prescribed for a variety of acute and chronic pain states. Unfortunately, prescribed opioids can be tampered with or diverted, both of which can have s...
Bayesian neurobehavioral phenotyping: from mechanism identification to personalized neuromodulation treatments
PROJECT SUMMARY Dysregulated activity within the neural networks that underlie reward and executive functions can increase vulnerability to compulsive drug use. Repetitive transcra...
Metabolic determinants of reactive astrogliosis and cognitive heterogeneity in aging
ABSTRACT The greatest risk factor for Alzheimer’s disease and related dementias (ADRD) is aging, but the mechanisms that link aging to ADRD disease processes are largely unknown. O...
Informal Caregiving Networks of Older Adults with Dementia
ABSTRACT In 2021, approximately 11 million Americans provided unpaid care to an adult with Alzheimer’s disease and related dementias (ADRD), which was estimated to be 16 billion ho...
Modulating blood flow and metabolism in Alzheimer's Disease models
ABSTRACT This project will develop and apply new intravital microscopy techniques to gain greater insight into the putative benefits effects of gamma entrainment, a promising nonph...
Airway compromise and skeletal muscle rigidity as toxicity contributors in synthetic opioid and methamphetamine co-administered rats
The United States is battling a drug overdose crisis fueled by deaths from the synthetic opioid fentanyl and from the neurostimulant methamphetamine. A better understanding of the...
Targeting miRNA-loaded exosomes to HNSCC with Dsg2-directed scFv fusion proteins
PROJECT SUMMARY/ABSTRACT Advances in immunotherapy, especially PD1/PD-L1 immune-checkpoint inhibitors (ICI), are revolutionizing the approach to personalized treatment for head and...
Longitudinal impact of midlife cerebrovascular pulsatility on brain tissue integrity and cognitive aging
PROJECT SUMMARY Normal aging is associated with a gradual decline in cognitive abilities across the lifespan, which is accelerated by midlife vascular risk factors, including stiff...
Investigating the Role of Hepatic Glucagon Receptor Signaling in Healthspan and Aging
Project Summary: Obesity and type 2 diabetes mellitus accelerate aging shortening the duration of healthspan. Conversely, chronic calorie restriction extends healthspan. Most resea...
Population-level interventions and community environment effects on obesity among diverse Asian American ethnic subgroups
PROJECT SUMMARY Childhood obesity prevalence keeps rising, especially among school-age children, and varies by race/ethnicity. Children of origins in Asia and the Pacific Islands (...
Regenerative biomaterial for combating genitourinary syndrome of menopause
Project Summary Genitourinary syndrome of menopause (GSM) is an extremely prevalent condition consequent to the hypoestrogenic changes in the genitourinary tract that affects up to...
Functional consequences of the interactions between tau protein and opioids
PROJECT SUMMARY The opioid epidemic is a persistent public health crisis that has been worsened by the COVID19 pandemic. Efforts to curtail this epidemic have had minimal success i...