Browse All Grants
99,167 grants found
Showing 821 – 840 of 99,167 grants
The role of norepinephrine transporter phosphorylation in amphetamine reward
SUMMARY Substance use disorder (SUD), including use of the psychostimulant amphetamine (AMPH) and its congeners, is on the rise, especially in the Covid-19 pandemic era. There are...
Unraveling the systemic manifestations of pulmonary arterial hypertension on lean muscle mass
Project Summary While pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature associated with high morbidity and mortality, it also has multiple...
Novel methods for estimating the prevalence of drug use among older adults
Drug use among older adults has increased sharply over the past decade. The combination of the aging and increasing use of psychoactive drugs, including misuse of prescription psyc...
Sex-based study of chronic hypoxia-related vulnerability to depression: age effects
Risk for major depressive disorder (MDD) risk increases with aging. Later-life depression affects 12-40% of people over 65yrs old, with biological risk factors including female sex...
Dysregulation of amyloid-β metabolism by impaired METTL3-m6A signaling in Alzheimer's Disease
Deposition of amyloid plaques is a major pathological hallmark in brains of Alzheimer’s disease (AD). Excess accumulation of amyloid-β (Aβ), caused by increased Aβ production and i...
High-resolution 3D tracking of social behaviors for deep phenotypic analysis
Project Summary The aim of this proposal is to plan for and deliver a proof-of-concept solution for an innovative and easy-to-use experimental platform for measuring and quantifyin...
The effects of poverty reduction intervention on health outcomes among women and young children in low- and middle-income countries
ABSTRACT Poverty long has been recognized as an important social determinant of health. Despite many years of progress, in 2018 nearly 10% of the world's population lived in e...
Role of mitochondrial Complex I deficiency in Alzheimer disease and dementia
Summary Alzheimer’s disease (AD) and dementia present enormous social and economic burdens to the United States. In 2019, AD was recognized as the sixth leading cause of death (121...
Understanding the Neurophysiology of Ankle Instability to Improve Rehabilitation Outcomes
Understanding the Neurophysiology of Ankle Instability to Improve Rehabilitation Outcomes Abstract Chronic ankle instability is a common debilitating orthopedic condition that disr...
Prescription of Step Counts for Targeted Changes in Body Composition and Cardiometabolic Risk in Overweight/Obese Adults
The prevalence of overweight and obesity remains epidemic in the United States, with some of the highest rates seen in older adults. While this phenomenon is certainly multifactori...
Are Ending the HIV Epidemic goals attainable across race/ethnic groups, risk groups, and settings?
Project Abstract In collaboration with the Shelby County Health Department, which has jurisdiction over Memphis as well as rural northwest Mississippi and Arkansas, we propose to i...
Development of a behavioral economic Intervention to improve HIV-related behaviors among sexual minority men.
Abstract Sexual Minority Men (SMM), particularly SMM 18-34-years old are disproportionately affected by HIV in the United States (U.S), accounting for 68% new HIV diagnoses in the...
Effectiveness and Implementation of a Meditation App addressing Substance Use, Sexual Health, and Emotion Regulation among Legal-Involved Youth
Young people are arrested at high rates in the U.S., particularly in minoritized communities, and face stark behavioral health disparities related to substance use and sexual healt...
Spinal Circuit Mechanisms of Visceral Sensory Transmission and Regulation
Visceral pain is a key feature of functional gastrointestinal (GI) disorders such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and obstructive bowel disorde...
Defining the role of antigen-specific T cell responses in NASH
Project Summary Chronic liver diseases are a collection of disorders that result in significant morbidity and mortality worldwide. The overwhelming burden of these diseases results...
Genomic Basis of Telomere Length Regulation and Consequences for Complex Traits
PROJECT SUMMARY Telomere length is considered a good biomarker of organismal and cellular aging. Telomeres get progressively shorter with each cell division and rates of cellular t...
Cerebral microhemorrhages and gait abnormalities in aging
Project Summary/ Abstract The growing prevalence of multifocal cerebral microhemorrhages (CMHs), also known as "cerebral microbleeds," is a significant and newly recogniz...
Identifying Successful Strategies of Specialist Palliative Care Implementation for People with Advanced Heart Failure
Project Summary Over 280,000 people die from advanced heart failure each year in the United States. This population experiences burdensome symptoms, frequent hospitalizations, and...
Molecular Targets Modulating Neuro COVID Sequelae Linked to Tauopathy
The COVID-19 pandemic caused by SARS-CoV-2 (CoV2) virus has left a large cohort of individuals suffering from ongoing neurological sequelae known as neuro-COVID. The condition invo...
Utilizing the NHANES-Linked Medicaid Data to Understand the Role of Preconception Lifestyle Factors on Pregnancy Outcomes
PROJECT SUMMARY Although lifestyle factors have been investigated for their potential to modify risk of adverse pregnancy outcomes, initiating interventions during pregnancy may no...