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99,167 grants found
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Pubovisceral muscle enthesis injury: A bioinspired approach to repair
PROJECT SUMMARY Each year, at least 20% of women who give birth vaginally sustain an avulsion of the pubovisceral muscle enthesis (PVME) at the pubic bone, substantially predisposi...
Prospective Health Impacts of Chronic Binge Eating Disorder in Hispanic Older Women Living with Food Insecurity (PROSPERA)
ABSTRACT Women live longer than men, yet they also experience greater morbidity, which makes understanding how specific chronic conditions further impact multimorbidity in women es...
CRCNS: Assessing long-term impacts of disruption to large-scale brain networks
Large-scale complex networks support brain function across the lifespan, and features of brain networks are hypothesized to confer both vulnerability and resilience to the brain ch...
CRCNS: Mechanisms and consequences of infraslow oscillations in sleep
During sleep, the mammalian brain alternates between two major brain states, rapid eye movement (REM) and non-REM (NREM) sleep. Recent work showed that the electroencephalogram (EE...
Measuring Digital Clinical Endpoints in Huntington's Disease (MEND-HD)
PROJECT SUMMARY (ABSTRACT) As genetic and disease-modifying interventions emerge, there is an urgent need for early and accurate assessment of disease-specific motor impairments in...
Implementing a Low-Threshold Hepatitis C Treatment in a Jail Setting
PROJECT SUMMARY Carceral facilities, particularly jails, present a unique opportunity to address the public health crisis of hepatitis C virus (HCV) and HIV among people who inject...
Neurotensin receptor 1 as a novel target for opioid use disorder and discovery of new small molecule probes
PROJECT SUMMARY Submitted in response to RFA-DA-24-063, we propose to develop novel, brain-penetrant, small molecule biased allosteric modulators (BAMs) of the neurotensin receptor...
Preclinical Trial: Targeting the Neuropeptide S Receptor to Curb Opioid Taking and Seeking
Summary Substance use disorders have a devastating impact on individuals, families, and society. Present pharmacological treatments do not fully ameliorate patients’ symptoms and i...
Exploring the Molecular, Neuro-immune and Behavioral changes during HIV-associated progressive aging using a long-term humanized mice model
Abstract Aging is associated with persistent levels of inflammation, which is also a hallmark of HIV infection. The effects of aging are particularly important to the population of...
PKDNet - ARPKD Learning Network
PROJECT SUMMARY / ABSTRACT Autosomal recessive polycystic kidney disease (ARPKD) is a rare disease, affecting ~1,500 children and young adults in the U.S. In severely affected pati...
Morphogenetic mechanisms of intestinal lymphatic smooth muscle-lacteal complex function and dysfunction
ABSTRACT The lymphatic vasculature is essential for organogenesis and dietary fat absorption and the intestinal villus plays the leading role in this process. However, the developm...
Fluxomics Studies of the Effect of Diet Composition on Energy Metabolism
Obesity, a major risk factor for multiple diseases including diabetes and cardiovascular disease, has reached pandemic level and is still increasing alarmingly in the US and worldw...
Role of ULK2 in selective protein degradation and protection against sarcopenia
PROJECT SUMMARY/ABSTRACT The US population continues to age, and millions of people will likely be affected by age-related muscle atrophy and weakness (also referred to as sarcopen...
Multicolor mouse models to resolve hematopoietic stem and progenitor cells in vivo
PROJECT SUMMARY: Hematopoietic stem cells (HSCs) are at the top of a hierarchy of differentiating progenitor cells that can reconstitute the entire blood and immune system. Proper...
Cellular and molecular mechanisms governing bladder aging.
PROJECT SUMMARY / ABSTRACT Bladder conditions such as incontinence and urinary tract infections (UTI) are increasingly common with aging and driven by poorly understood changes tha...
Control of Drosophila intestinal homeostasis by RhoGap15b
Project Summary/Abstract The overall goal of this proposal is to understand how organisms as diverse as humans and the fruit flies use the same molecules to decide when and where c...
Regulation and Requirements for Coenzyme A Biosynthesis
Metabolic dysfunction-associated fatty liver disease and chronic kidney disease, affecting tens of millions of people in the US alone, exhibit pathological dysregulation of lipid m...
The Effects of the Medicaid Continuous Coverage Requirement during the Public Health Emergency on Postpartum Coverage and Maternal and Infant Care after Childbirth
PROJECT SUMMARY/ABSTRACT Career Goal: My long-time career goal is to become an independent investigator studying the effects of health care policies on access and use of maternal a...
Co-use of cannabis and prescription opioids in emerging adults in medical settings
The transition from adolescence to adulthood is characterized by increased rates of prescription opioid use and related problems. These rates may be even higher among emerging adul...
Multi-Resolution Docking Methods for Electron Microscopy
Summary In the past decade, we have witnessed revolutionary progress in the attainable resolution of macromolecular assemblies via cryo-electron microscopy (cryo-EM) and in the dev...