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99,167 grants found
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WISP3 and Progressive Pseudorheumatoid Arthropathy of Childhood
Novel strategies are needed when standard approaches fail to delineate mechanisms by which mutations cause disease. This is the case for Progressive Pseudorheumatoid Arthropathy of...
The Role of the Urban/Rural Divide and Socioeconomic Factors in the Incidence, Outcomes and Post-partum Care of Hypertensive Disorders of Pregnancy
PROJECT SUMMARY/ABSTRACT In this proposal, we will quantify disparities in incidence, short- and long-term outcomes, and barriers to post- partum care in women with hypertensive di...
Indole Metabolites as Xenobiotic Danger signals in Acute Lung Injury
ABSTRACT This application is for an NHLBI R01 entitled “Indole Metabolites as Xenobiotic Danger Signals in Acute Lung Injury.” I am a physician in Pulmonary and Critical Care Medic...
The Role of SoxE Transcription Factors in Neural Crest Cell Specialization
Project Summary/Abstract Neurocristopathies are a class of syndromes that are predominately characterized by malformations in the craniofacial complex. These defects are caused by...
Nutrient-sensitive protein modifications regulate daily biological rhythms
PROJECT SUMMARY Robust daily biological rhythms over the 24-hour (h) day-night cycles are key hallmarks of animal healthspan and are strongly regulated by circadian clocks. Circadi...
Do opposing amygdala-striatal pathways enable chronic stress to promote habit formation?
PROJECT SUMMARY When making a decision we can use our understanding of available action-outcome relationships to prospectively evaluate the consequences of our potential actions an...
Targeting PFC interneurons for personalized treatments in OUD
Abstract New treatments are desperately needed for opioid use disorder (OUD). Approved medications and available treatments do not adequately address long-term changes in mood, mot...
Advancing Genomic Interpretation for Chromatin Remodeling Enzymes
PROJECT SUMMARY/ABSTRACT The functional interpretation of human genetic variation needs to catch up to our ability to catalog the DNA sequences of individuals. Better tools are req...
Surrogate Assessment of Frailty using Electronic Tools (SAFE-T)
PROJECT SUMMARY Each year, ~1 million Americans survive a critical illness only to suffer with new-onset frailty. This accelerated, catastrophic, critical illness-associated form o...
New Super-Accurate and Super-Resolved Fluorescence Microscopy Techniques and Probes for Studying Single Molecular Motors
The long-range goal of my laboratory is to measure the conformations of biomolecules at the single molecule level with nanometer and (sub)-millisecond resolution, ultimately in a c...
Endothelial mechanisms of multiorgan dysfunction
PROJECT SUMMARYThree different fates await the millions of critically ill patients admitted to intensive care units every year. Close to 30% will recover without obvious sequelae,...
Biobehavioral Mechanistic Model of Alcohol Use Following Bariatric Surgery: The BREW ME Model
Biobehavioral Mechanistic Model of Alcohol Use Following Bariatric Surgery: The BREW ME Model Abstract Metabolic and bariatric surgery (MBS) is currently the most efficacious and d...
The impact of and path forward for telehealth on reducing disparities in severe maternal morbidity: A community engaged mixed-methods study
PROJECT SUMMARY The maternal mortality rate in the United States (US) is the highest among high-income countries and has been steadily rising in recent years. Near misses for mater...
Rgs7 regulation of the Kappa Opioid Receptor
The kappa opioid receptor (KOR) is part of the opioid neuromodulatory system that influences pain and mood perception. KOR agonists have been recognized for their analgesia propert...
A Longitudinal Examination of the Social and Environmental Influences on Substance Use among Non-Prescriber/Non-Executive Healthcare Workers in the United States
Healthcare workers represent a large and growing segment of the US workforce, and the strain of the COVID- 19 pandemic on the healthcare system has brought to light the significant...
Pain in the Elderly: Role of Hyperalgesic Priming
Abstract Management of pain is a significant problem in the elderly, with the burden of chronic pain heavily tilted toward older adults. The high incidence of pain in the elderly h...
Developing graphene grids to overcome air-water-interface issues
SUMMARY Single particle cryoEM is now a ubiquitously employed methodology for high-resolution structure determination of biomedically important macromolecular complexes. CryoEM str...
Mitigating Delirium with Fluvoxamine Treatment for Non-Cardiac Surgery (MD FluNCS): Feasibility Trials & Mechanistic Insights
ABSTRACT The pathogenesis of postoperative delirium likely involves systemic inflammation, downstream neuroinflammation, and altered synaptic plasticity reflected by elevations in...
Acculturative stress and pro-inflammatory markers among Mexican-Origin adults with NAFLD
ABSTRACT Non-alcoholic fatty liver disease (NAFLD), an emerging risk factor for hepatocellular carcinoma (HCC), disproportionately impacts the Mexican-origin (MO) population. This...
Heavy Menstrual Bleeding Progestin Treatment in Bleeding Disorders Study
ABSTRACT Heavy menstrual bleeding (HMB) is common among adolescents and young adults with a heritable bleeding disorder (BD) and negatively impacts health-related quality of life a...