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99,167 grants found
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Barriers to Screen for Domestic Violence among Women in Emergency Department
PROJECT SUMMARY ABSTRACT Domestic violence (DV) includes physical and sexual violence, threats, economic, and emotional/psychological abuse, or other abusive behavior as part of a...
Alcohol assoCiated gut Dysbiosis and CVD in HIV (the AC/DC HIV study)
PROJECT ABSTRACT: Among people with HIV infection (PWH), hazardous drinking is a common, modifiable risk factor for cardiovascular disease (CVD) and death. Both alcohol and HIV cau...
Modernizing the family-based association testing (FBAT) approach and its software implementation in the FBAT-program
Developed for linkage and candidate gene studies, family-based association tests (FBATs) have played a fundamental role in the disease mapping efforts of the human genome project....
Computational Methods for Systems Genetic Analysis of Rare Polygenic Disorder
Idiopathic Pulmonary Fibrosis (IPF) inflicts a significant healthcare burden and high rate of mortality in the U.S. Current treatment options can slow the rate of lung function dec...
Technology-based Sleep Self-Management Intervention for Adults with Subarachnoid Hemorrhage
PROJECT SUMMARY/ABSTRACT Subarachnoid hemorrhage (SAH) accounts for 27% of all stroke-related years of potential life lost before 65-years of age. Sleep disturbance (insufficient s...
Alternative polyadenylation in Right Ventricular Fibrosis
Project Summary: Pulmonary hypertension (PH) is a cardiovascular disorder characterized by high mortality, primarily due to right ventricular (RV) failure (RVF) caused by increased...
Psychosocial and cultural determinants of cardiometabolic health among older Chinese Americans
Project Summary Cardiometabolic diseases contribute to more than 1 in 4 deaths in U.S. adults, including Asian Americans. Psychosocial stress is believed to be a key risk factor le...
Mechanisms of right ventricular dysfunction in type 2 diabetes
PROJECT SUMMARY Heart failure in the presence of diabetes is common, expensive, and growing in significance, with some estimates suggesting that diabetic cardiomyopathy is present...
Fully Realizing Pangenomics Alignment
PROJECT ABSTRACT Read aligners first build an index from one or more reference genome(s) and subsequently use it to find and extend matched subsequences between sequence reads and...
Integrating the impacts of genetic variation with massively parallel mRNA and protein barcoding
SUMMARY The human genome supports billions of potential variants, and the number of variants detected through genome sequencing continues to grow rapidly. However, our ability to i...
Long-term, non-clinical toxicology for advancing CMS121 to Phase 2 trials for AD
Abstract Our goal is to advance CMS121 to a Phase 2 clinical trial by conducting the long-term non-clinical toxicology studies needed to support a long-term course of daily adminis...
Mechanisms of Chromosome Fragile Site Formation in the Human Genome
PROJECT SUMMARY/ABSTRACT Common fragile sites (CFSs) are recurrent “wounds” in every person's genome that predispose the chromosomes to DNA double strand breaks (DSBs) and rea...
Drug repurposing of a novel synthetic progestin for the prevention of preterm labor and fetal inflammation
Abstract Intrauterine infection/inflammation (IUI) is a major contributor to preterm labor and fetal inflammation leading to injury responses in fetal organs such as the brain, lun...
Executive Function Impairments in HAND and Aging
Project Summary: With the great success of combination antiretroviral therapy (cART), older adults (>50-years of age) now account for 30–50% of HIV-1 seropositive individuals in...
Self-regulation of real-time fMRI brain activity in chronic pain: A potential neurobiological mechanism of cognitive behavioral therapy
Project Summary/Abstract Self-regulation is the ability to manage one’s thoughts, emotions, and behaviors to achieve desired goals through a variety of cognitive and emotional proc...
Understanding Mechanism of Functional Dynamics Through An Explainable Neural Network Landscape with Geometric Control
Project Summary/Abstract One of the fundamental scientific problems in neuroscience is to have a good understanding of how cognition and behavior emerge from brain function. Tremen...
Exposure to Metal-Mixtures and Coronary Heart Disease Across Diverse Populations
Coronary heart disease (CHD) is the leading cause of mortality and disability worldwide, and accounts for 13% of global deaths and 370,000 deaths annually in the US. Accumulating e...
Development and preliminary testing of a peer narrative video intervention for older adults with chronic pain
Chronic musculoskeletal (MSK) pain, which includes spinal pain, osteoarthritis, and fibromyalgia, is a common and costly problem for older adults and is associated with decreased q...
Advancing High-Resolution Charge Detection-Mass Spectrometry
Project Summary Charge detection mass spectrometry (CD-MS) is an emerging technology that allows accurate mass distributions to be measured for heterogeneous and high mass samples....
Autoantibodies to membrane repair proteins in myositis
Project Summary Idiopathic inflammatory myopathies (IIM) are a group of inflammatory disorders characterized by muscle weakness and are associated with significant morbidity and mo...