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A 3D DCE-US Interconnected Voxel Analysis Framework for Bedside Characterization of Tumor Vascular Properties in Liver Malignancies.
PROJECT SUMMARY/ABSTRACT Tumor vascular networks are highly abnormal and complex, vary significantly by tumor type and on a patient- by-patient basis. More importantly, patient-spe...
Investigating Suicide Risk and Protective Factors among Economically Disadvantaged, Preteen Black Youth
Suicide among Black preadolescents has increased rapidly over the last two decades, reaching unprecedented levels. While there have been substantive gains in knowledge related to t...
Health-associated oral bacteria as anti-cancer and immunomodulatory agents in oral cancer
PROJECT SUMMARY Oral squamous cell carcinoma (OSCC) exerts a significant clinical and financial burden worldwide. OSCC continues to have poor prognosis despite advances in treatmen...
Non-rotating nano-optic endoscope for 360 degree in vivo imaging
Endoscopic optical imaging has the potential for providing critical clinical imaging feedback for a variety of lumi- nal organs, with notable applications identified in the cardiov...
Assessment of Uterine Cervical Insufficiency using 4D Contrast-Enhanced Ultrasound
Cervical insufficiency (CI) describes the inability of the uterine cervix to retain a pregnancy in the absence of the signs and symptoms of clinical contractions, or labor, or both...
How Do OpenNotes Policies Affect Healthcare Disparities? A Computational Approach
Project Summary/Abstract The new OpenNotes rule in the United States enables all patients easy access to their medical records. The policy affords many benefits to patients such as...
Lateralization of posterior-parietal cortex contributions to motor learning
Project Summary: Motor learning is fundamental for humans to become proficient in daily activities, such as self-care, work, and leisure. Two fundamental components of motor learni...
Phylodynamic mechanisms of HIV reservoir seeding and maintenance
PROJECT SUMMARY The HIV reservoir is a population of latently HIV infected cells that persists in people living with HIV on suppressive antiretroviral therapy (ART) and prevents cu...
The SUSTAIN 2 study - SUStained HIV Treatment for Adherence After Interruption in Care
PROJECT SUMMARY South Africa bears the brunt of the global HIV epidemic, with over one-fifth of the 37 million people living with HIV within its borders. While we have seen tremend...
Ethical Approaches to Informed Consent for Autonomous Robotic Assisted Surgery
PROJECT ABSTRACT Surgery is on the verge of a paradigm shift towards autonomous robot-assisted surgeries (RAS). Increasingly, RAS is incorporating artificial intelligence (AI) algo...
Control of Mammalian Craniofacial Morphogenesis by the ESCRT Machinery
Abstract Signaling molecules and their receptors rely on endo-lysosomal trafficking to prevent their accumulation on the plasma membrane, which would perturb craniofacial developme...
RNA localization in neural crest migratory protrusions
SUMMARY A fundamental question in developmental biology is how migratory cells initiate migration, move in a directed fashion towards their target, terminate migration and differen...
The Role of Brain-Oral-Microbiome Axis in Adverse Childhood Experiences-associated Dental Caries in Children
PROJECT SUMMARY/ABSTRACT Adverse childhood experiences (ACEs), traumatic experiences encountered during early life stages, can profoundly impact health and well-being into adulthoo...
SoS:B10:ldentifying and Encouraging Connections among Data Reuse, Scientific Innovation, and Scientific Careers
PROJECT SUMMARY {See instructions): This project has two main goals: measuring the impact of research data reuse on diversity and novelty, and identifying synergistic data-method-r...
Tspan14 expression and function in cardiovascular disease
PROJECT SUMMARY/ABSTRACT Genetic predisposition is a significant risk factor for coronary artery disease (CAD), the leading cause of mortality. Most CAD risk variants identified in...
Functional amyloid formation in streptococcus mutans
ABSTRACT Dental caries, the most common microbial disease, is caused by overgrowth of acidogenic and aciduric bacteria including Streptococcus mutans. Childhood caries incidence in...
Extreme Weather Impacts on Children's Acute and Chronic Health Outcomes: A Multi-Site Study with Evaluation of Vulnerabilities
PROJECT SUMMARY/ABSTRACT Climate change-related extreme weather – extreme heat, heatwaves, and intense rainfall – pose an urgent threat to public health. Children may bear a dispro...
CD45 mediated regulation of PMN function during intestinal inflammation
Abstract: It has been well documented that disease activity in inflammatory mucosal diseases including inflammatory bowel disease is linked to the transepithelial migration of neut...
The impact of peripheral injury on central vestibular pathways
The vestibular system is crucial for postural control and the perception of head and body movement in space. Older adults and those with neurodegenerative disease often are affecte...
Comparative effectiveness study of current treatments in children with Chronic Nonbacterial Osteomyelitis (CNO)
Project Abstract Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), is a severe autoinflammatory bone disease of unknown cau...