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99,167 grants found
Showing 741 – 760 of 99,167 grants
Investigation of the renin-angiotensin system at the maternal-fetal interface.
PROJECT SUMMARY There is evidence from human and animal studies that support that imbalance in the renin-angiotensin system (RAS), specifically reduced ACE2 protein levels and/or a...
4/7-PsycheMERGE: Advancing Precision Psychiatry
PROJECT SUMMARY Psychiatric disorders remain a leading cause of disability in the US and are associated with increased morbidity and mortality. Early detection and treatment is ess...
Creating a state-level policy data dashboard to facilitate research on reproductive health
The study of state-level Sexual and Reproductive Health (SRH) policies and their impact on health outcomes is hindered by the absence of a comprehensive, longitudinal database. The...
3/7-PsycheMERGE: Advancing Precision Psychiatry
PROJECT SUMMARY Psychiatric disorders remain a leading cause of disability in the US and are associated with increased morbidity and mortality. Early detection and treatment is ess...
Development and Testing of a Pediatric Anxiety Outcomes Quality Measure (PAO_QM Study)
0BPROJECT SUMMARY/ABSTRACT This project will create two complementary quality measures focused on pediatric anxiety. Pediatric anxiety disorders are the extremely prevalent and rat...
Reducing racial disparities and achieving health equity in lung cancer treatment among the underserved
PROJECT SUMMARY/ ABSTRACT Lung cancer is the most lethal cancer and is responsible for 1.8 million deaths worldwide. Blacks are 15% less likely to be diagnosed early, 10% more like...
7/7-PsycheMERGE: Advancing Precision Psychiatry
PROJECT SUMMARY Psychiatric disorders remain a leading cause of disability in the US and are associated with increased morbidity and mortality. Early detection and treatment is ess...
Assessment of placenta vascularization development using contrast-enhanced ultrasound
During gestation, the uterine vasculature undergoes numerous physiologic modifications in order to bring the necessary quantitative increase in blood flow to support placental deve...
The impact of organophosphate flame-retardant exposure on metabolic and brain aging
PROJECT SUMMARY Persistent organic pollutants such as organophosphate flame retardants (OPFRs) can accumulate in the body and interact with nuclear receptors important in endocrine...
Responding to Community Trauma: A Feasibility and Effectiveness Study of An Interdisciplinary Anti-Racist, Structurally Competent, and Culturally Responsive Assessment Model
Project Summary/Abstract Children's community violence exposure (CVE) is a public health crisis, and racial and ethnic disparities are well-documented. As a source of toxic st...
The adult leopard gecko, an emerging, unconventional experimental model for dental research
7. PROJECT SUMMARY The long-term goal of the proposed research is gain fundamental insights into the process of tooth generation and loss using the innovative leopard gecko model....
Skipping the hospital: acute hospital care at home for people living with dementia
PROJECT SUMMARY – Skipping the hospital: Acute hospital care at home for people living with dementia In 2020, Alzheimer’s Disease and Related Dementias (ADRD) affected 5.8 million...
Biotype-assigned Augmentation Approach in Resistant late life Depression (BAARD)
PROJECT SUMMARY/ABSTRACT Up to half of depressed older adults do not respond to an initial antidepressant, and fewer than 20% achieve remission. Using a robust multi-site clinical...
Life course impacts of reduced access to contraception
PROJECT SUMMARY Subsidies for contraception and even the right to use contraception are often justified on the basis of their benefits to women’s socioeconomic lives. While the ben...
National and Institutional Leadership and Support of NCI-Sponsored Clinical Trial Research as a Surgical Oncologist
Project Summary: Dr. Akhil Chawla plays a pivotal role in the NCI clinical trials program at Northwestern University Robert H. Lurie Comprehensive Cancer Center (RHLCCC). As a Surg...
Dynamic Sustainment of Evidence-Based Health Promotion Interventions in Mental Health
PROJECT ABSTRACT Adults with serious and disabling mental illness (SMI) experience a 15-30-year reduced life expectancy primarily due to modifiable cardiovascular risk factors that...
Prediction, mechanisms and causality: a systems biology approach to elucidate the role of the dynamic interplay between maternal and microbial systems in the pathobiology of perinatal depression
PROJECT SUMMARY Perinatal depression (PND), defined as depression during pregnancy and up to one year postpartum, affects more than 20% of pregnancies and disproportionately impact...
The Future of Families and Child Wellbeing Third Generation Children’s Study
ABSTRACT Intergenerational transmission of inequalities in economic and social wellbeing, including health, in the United States has been well documented and shown to account for a...
Optimizing early phonological awareness instruction to support reading and spelling acquisition
Project Summary/Abstract Reading difficulties continue to be a pervasive public health issue. Many children, particularly those from marginalized populations, experience reading di...
A SYSTEMS THEORY APPROACH TO THE STUDY OF COLON AND LUNG CANCER HEALTH DISPARITIES USING NOVEL DATA LINKAGES
Abstract We will conduct innovative linkages between our state cancer registry, all-payer claims data, and mental health treatment sources from the South Carolina Integrated Data W...