Browse All Grants
99,167 grants found
Showing 721 – 740 of 99,167 grants
Real-time and randomized tests of social media and mental health interplay in early adolescence
PROJECT SUMMARY Adolescent mental health has worsened over the last decade and increased time spent on social media is often cited as a contributing factor. Parents, policymakers,...
Saliva Anti-SSA/Ro and Anti-SSB/La for Early Detection of Sjögren’s and SICCA Syndromes
Project Summary/Abstract: Early detection of Sjögren’s Disease (SjD) and its precursor autoimmune-Sicca Syndrome (AI- Sicca), are unmet clinical needs. Serum anti-Ro/SSA autoantibo...
Effect of dysbiotic gut microbiota on the transport of short-chain fatty acids: Relevance to autoimmune disorders
Summary Short-chain fatty acids (SCFAs) are metabolites produced by the fermentation of fibers by bacteria in the gut and play an important role in the maintenance of health and di...
Modeling Adolescent Health Care Decision-Making for Vaccines: A Community- Based Participatory Approach
ABSTRACT In the US, state and local laws allowing minors to consent to medical care can directly impact population health. Prior research suggests increased vaccine uptake among ad...
Deep learning methods for genotyping structural variants in human genomes
PROJECT SUMMARY: Structural variants (SVs) play a causal role in numerous diseases. However, our ability to detect and analyze disease-causing SVs, particularly de novo SVs, in sho...
Intervention to improve parent communication about sexuality with sexual minority male adolescents
Project Summary Parental acceptance after youth come out as LGBTQ is a protective factor for the health of this youth group; however, parents lack support in initiating and sustain...
A unified probabilistic model and software implementation for analysis of nascent RNA sequencing data
PROJECT SUMMARY The process by which RNA molecules are assembled from DNA templates, called transcription, is fundamental to all life and dysregulated in many human diseases. Over...
Developing and Validating a Multi-Dimensional Scale of Sexual Health
Project Summary Sexual well-being (SW), the cognitive and emotional evaluation of an individual's sexuality, is an important aspect of overall health and quality of life, yet...
Research Capacity Building by a Clinician Scientist within the Michigan Cancer Research Consortium- National Community Oncology Research Program
PROJECT SUMMARY/ABSTRACT This Clinician Scientist project is proposed by Elie Dib, MD, MS, FACP, a member of the Michigan Cancer Research Consortium (MCRC)-National Community Oncol...
Multimodal AI Fusion Model for Early Detection for Pancreatic Cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC), accounting for 90% of all pancreatic cancers, is among the deadliest, due largely to late-stage diagnosis and the aggressiv...
RCT of a Measurement Feedback App to Improve Data Quality, Supervision & Outcomes in Behavioral Health
PROJECT SUMMARY/ABSTRACT Decades of treatment studies demonstrate that youth with significant behavioral health needs make more progress when their treatment planning is informed b...
Trustworthy and High-Performance Question Answering for Electronic Health Records
ABSTRACT Patients accumulate large volumes of information in their electronic health record (EHR), and finding this information often proves difficult, especially given the usabili...
Characterizing the role of Elevated dNTP pools in sensitizing the replisome
PROJECT SUMMARY The fidelity of DNA replication is critical in ensuring the stability of the genome from cell division to the next. Accurate DNA synthesis by replicative DNA requir...
An interactive and reproducible tool for enrichment analysis
PROJECT SUMMARY Interpretating large transcriptomic and proteomic datasets is challenging, particularly for researchers lacking computational training. Enrichment analysis bridges...
Massachusetts Outcomes Study of Assisted Reproductive Technology Equity
Project Summary Given the persistently stark racial/ethnic disparities in perinatal health outcomes in the U.S. and the increasing utilization of fertility treatment to achieve pre...
Telemedicine Use Among Assisted Living Residents with ADRD: Assisted Living, Market, and State Regulatory Factors
Project summary: Today, assisted living communities (ALs) are a popular choice for older adults who can no longer maintain an independent lifestyle at home. However, ALs generally...
The role of antiretroviral therapy in susceptibility to oral human papillomavirus (HPV) infection
ABSTRACT People living with human immunodeficiency virus (HIV) infection (PLWH) remain at increased risk of developing head and neck squamous cell cancer (HNSCC) due to oncogenic h...
The impact of vaginal washing on cervical inflammation: a randomized controlled trial of women from sub-Saharan Africa at high risk for HIV acquisition.
Project Summary Vaginal washing is a common practice that many women perceive as hygienic. However, vaginal washing has been linked to adverse reproductive health outcomes includin...
Combating HIV Stigma in Healthcare Settings: A Standardized Patient Approach
40-years into the pandemic, stigma remains the most challenging barrier for HIV prevention. A quarter of people living with HIV remain untested, depriving them of opportunities to...
Mechanistic Evaluation of Macrocyclic Diterpenoids with Selective Triple Negative Breast Cancer Activity
PROJECT SUMMARY Triple-negative breast cancer (TNBC) is a highly heterogeneous disease largely devoid of targeted therapy due to the absence of estrogen, progesterone, and HER2 rec...