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99,167 grants found
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Multi-morbidity 3-City Alzheimer's Disease EHR Study (M3AD Study)
The overall goal of our proposal is to place patients impacted by Alzheimer’s Disease (AD) and Related Dementia (AD/ADRD), rather than the disease, at the center of the research in...
A Case-Cohort Study of Novel Determinants of Living Kidney Donor Risk
Living donor kidney transplantation is the best treatment for selected patients with end-stage kidney disease (ESKD). However, living kidney donation is not without medical consequ...
The role of transcriptional corepressor CtBP2 as a metabolic sensor in acute kidney injury
Project Summary Acute kidney injury (AKI) is a common and severe complication in hospitalized patients, which is associated with high morbidity and mortality rates. Patients who su...
Differential redox regulation of vein and arterial smooth muscle cells in AVF stenosis
(PLEASE KEEP IN WORD, DO NOT PDF)Kidney failure impacts many, with 750,000 cases annually in the US and 2 million globally. Treatment options include kidney transplant or dialysis....
Develop Autophagy Activators to Treat Autosomal Dominant Tubulointerstitial Kidney Disease
Autosomal dominant tubulointerstitial kidney disease caused by uromodulin mutations (ADTKD-UMOD) is one of the most common hereditary kidney diseases. It represents as many as 25%...
B cells for treatment of ARDS
Survivors of acute respiratory distress syndrome (ARDS) manifest pulmonary and neurological sequelae, as clearly documented during the COVID-19 pandemic. The goal of this project i...
Mechanisms of coagulopathy and bleeding in acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia that is associated with disseminated intravascular coagulation and fatal bleeding. Although chemotherapy a...
Diverse effects of hemin on the endothelium contribute to pulmonary complications of sickle cell disease
Hemolysis, with the release of extracellular free heme and hemin, is thought to play a major role in the deadly pulmonary complications of sickle cell disease. Acute chest syndrome...
A biobehavioral Approach to Explore the Migration-food Insecurity Nexus as a Social Determinant of Cardiovascular Health
PROJECT SUMMARY/ABSTRACT Food insecurity is a toxic stressor in the context of forced migration, which increases health risk and contributes to health disparities. The proposed stu...
Personalized Prediction of Cardiovascular Outcomes through Machine Learning Analysis of Cardiac MRI and Genomics
Scientific Abstract Clonal Hematopoiesis of Indeterminate Potential (CHIP) is a condition of aging that has been associated with increased risk of heart disease and heart failure....
Motivational Enhancement and Device Support Interventions to Increase Continuous Positive Airway Pressure Therapy Adherence in Adults with Obstructive Sleep Apnea
PROJECT SUMMARY Despite decades of research documenting the benefits of continuous positive airway pressure (CPAP) therapy, this highly effective treatment is not initiated, implem...
A beneficial persistent DNA damage-induced immune response in aging
PRIJECT SUMMARY/ABSTRACT The systemic immune effects of DNA damage in aging and disease remain elusive. It is generally believed that immune responses triggered by transient DNA da...
Nutrition, late fetal and neonatal mortality in the African context
Project Summary Stillbirths and neonatal deaths are two adverse birth outcomes of critical global health relevance. In 2021, an estimated 1.9 million babies were stillborn, and 2.3...
Deconstructing fast amoeboid cell migration
Project Summary Many cells can travel from one place to another. This nomadic cell behavior is harnessed to form organs, seal wounds, and hunt down pathogens, but it is often dysre...
Craniofacial cartilage differentiation from human neural crest stem cells in 3D cultures
Craniofacial cartilage differentiation from human neural crest stem cells in 3D cultures Birth defects and injuries to the head and face require surgical reconstruction and rehabil...
Leveraging COVID-19 Insights to Develop Novel Behavior-Informed Multi-Task Machine Learning Frameworks for Targeted Public Health Interventions in Rural America
The Sars-CoV-2 pandemic presented unprecedented challenges in many areas of healthcare. One important area was accurately forecasting the need for resources such as testing, vaccin...
Neonicotinoid insecticides and female reproduction
Neonicotinoids are the most widely used insecticides in the world because they broadly target chewing and sucking insects. Imidacloprid (IMI) is a common neonicotinoid that account...
Unlocking Equity: Validating Methodologies & Evaluating Surgical Care for Incarcerated Individuals
PROJECT SUMMARY/ABSTRACT Over the past 25-years, the United States (US) has witnessed a fourfold increase in its prison and jail population, with nearly 70-90% coming from minority...
Determining the Feasibility of Virtual Tailored, Music-Based Relaxation for Anxiety Among Adolescent and Young Adult Cancer Survivors.
Clinical Problem: Up to 48.5% of adolescent and young adult (AYA, 15 – 39-years old) cancer survivors experience clinically relevant anxiety. Anxiety disrupts the successful achiev...
The role of CD73 in esophageal epithelial homeostasis
PROJECT SUMMARY Eosinophilic esophagitis (EoE) is a chronic, debilitating allergic disorder that is increasing in incidence worldwide, resulting significant health care and financi...