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99,167 grants found
Showing 681 – 700 of 99,167 grants
Never Again: Advancing the Prevention of Recurrent Child Sexual Abuse
Project Summary Child sexual abuse (CSA) is an adverse childhood experience with wide ranging effects on health, wellbeing, and development throughout the lifespan. The long-term g...
Dysregulated RNA metabolism in cell fate of maternal diabetes-induced neural tube defects
ABSTRACT Pregestational diabetes induces neural tube defects (NTDs), the second most common birth defects. We and others have shown that cellular stress, altered cell fate and epig...
Silent Brain Infarcts in Spontaneous Intracerebral Hemorrhage as a Prognostic Biomarker for Vascular contributions to Cognitive Impairment and Dementia (VCID)
PROJECT SUMMARY Spontaneous intracerebral hemorrhage (sICH) survivors are at high risk for developing vascular contributions to cognitive impairment and dementia (VCID). However, t...
Neutrophil-driven vascular inflammation in VCID and Mixed Alzheimer's Disease
Summary: Substantial reductions in brain blood flow are found in patients with and mouse models of neurodegenerative diseases, including Alzheimer’s Disease (AD). Vascular patholog...
Daily Impact of Sexual Minority Stress on Alcohol-Related Intimate Partner Violence among Bisexual+ Young Adults: A Couples' Daily Diary Study
Project Summary/Abstract This study is guided by a long-term goal of optimizing alcohol-related intimate partner violence (IPV; psychological, physical, sexual, and identity abuse...
Alcohol and the skeletal muscle clock
Project Summary/Abstract Alcohol is a well-known myotoxin that with sustained use can culminate in alcohol-associated muscle disease (AAMD), characterized by muscle weakness and fu...
SCH: A multimodal wearable device to measure physiologic coupling
Acute exacerbations, bouts of disease worsening, are common in many chronic conditions like chronic obstructive pulmonary disease (COPD). These exacerbations have drastic impacts o...
SCH: Versatile and Compact Telerobot with Haptic Feedback and Physics-Informed Simulation for Safety Enhanced Neurovascular Interventions
Stroke is a leading cause of mortality and chronic disability, which predominately occurs due to blood clots or plaques impeding the blood flow in the brain (ischemic stroke) or a...
Comparing pain phenotypes across lower back, knee, and TMJ
Abstract This research project aims to compare multi-domain pain phenotypes across various pain conditions, with a specific focus on the lower back, knee, and temporomandibular joi...
Local and Systemic Multi-Omics of TMJ Disorders
Project Summary/Abstract Temporomandibular Disorders (TMD) represent a spectrum of painful disorders that afflicts approximately 5 to 10% of the US population with approximate annu...
Improving Cancer Outcomes In Native American Communities (ICON)
OVERALL COMPONENT: PROJECT SUMMARY American Indian and Alaska Native (AI/AN) communities experience cancer incidence and mortality rates that are strikingly worse than those of the...
Improving Cancer Outcomes in Native American Communities (ICON) - Administrative Core
ADMINISTRATIVE CORE: PROJECT SUMMARY The Administrative Core (AC) provides the organizational nexus for the jointly conducted cancer research and career enhancement activities of t...
Improving Cancer Outcomes in Native American Communities (ICON) - Community Engagement Core
COMMUNITY ENGAGEMENT CORE: SUMMARY Community engagement is the foundation of our approach in ICON (the Improving Cancer Outcomes in Native American Communities U19 Center). Each of...
Water for Health: Strengthening Tribal Action for Cancer Prevention
PROJECT 2: WATER FOR HEALTH: PROJECT SUMMARY For decades, the Strong Heart Study (SHS) has collaborated with American Indian/Alaska Native (AI/AN) communities in the Northern Plain...
Lung Cancer Screening to Improve Equity in Tribal Communities in Oklahoma (Lung-Screen-Tribal OK)
PROJECT 2: OK-LUNG-SCAN OK: PROJECT SUMMARY Lung cancer is the leading cause of cancer mortality among American Indian and Alaska Native (AI/AN) populations, especially in rural Ok...
Care Coordination and Communication Program in Oncology for Tribal Health Systems
PROJECT 3: C3PO CARE COORDINATION: PROJECT SUMMARY Despite significant improvements in their overall health, AI/AN populations continue to face marked disparities in cancer outcome...
Multi-omic dissection of clonal hematopoiesis-associated diseases
Project Summary Self-renewing cell populations accumulate somatic mutations with aging and/or in response to environmental insult and chronic inflammation. Most of these mutations...
3D body shape analysis for predicting sarcopenia and obesity in older adults
Project Summary If successful, the proposed study will provide accessible and scalable methods with measurable and validated accuracy to assess key indicators of an older adult’s h...
Early Life Predictors of Airway to Lung Dysanapsis
PROJECT SUMMARY/ABSTRACT Chronic obstructive pulmonary disease (COPD) accounts for 6% of all deaths worldwide and is potentially preventable, with well-described but poorly elucida...
Driving lymphoid potential in multipotent hematopoietic progenitors by linker histones
Driving lymphoid potential in multipotent hematopoietic progenitors by linker histones Abstract Functionally impaired hematopoietic stem and progenitor cells (HSPCs) often display...