Browse All Grants
99,167 grants found
Showing 661 – 680 of 99,167 grants
Core C: Mouse and Cell Phenotyping Core
Core C has two overarching goals: (1) to provide reliable and technically consistent complex murine models of lung transplantation to identify pathways causally linked to primary g...
Synergistic roles of lung autoantibodies, donor nonclassical monocytes and recipient classical monocytes in mediating primary graft dysfunction
PROJECT 1 SUMMARY Primary graft dysfunction (PGD) affects over 50% of recipients within the first 24-72 hours after lung transplantation. PGD is the dominant risk for post-operativ...
Physiologic and molecular mechanisms linking gastroesophageal reflux with chronic lung allograft dysfunction
The goal of this proposal is to elucidate physiologic mechanisms that promote gastric aspiration in lung transplant recipients and identify molecular mechanisms by which microaspir...
Crosstalk between profibrotic monocyte-derived macrophages and T cells in the pathobiology of CLAD
Project Summary: For many patients with advanced lung disease, lung transplantation remains the only viable therapeutic option to extend life. However, the 5-year survival for pati...
Mitochondrial integrated stress response and lung allograft dysfunction
PROJECT SUMMARY - ESI PROJECT Lung transplant outcomes are the worst among solid organ transplants in large part due to the nearly universal development of chronic lung allograft d...
Disease transmission along complex human-animal networks: a novel method for improving zoonotic disease modeling
ABSTRACT Endemic and emerging zoonoses both represent profound threats to public health. While these two disease systems diverge in many ways, fundamental to both is the importance...
Fostering Ethical Adoption of Artificial Intelligence-Enabled Assistive Robots (AIAR) Grounded in Person-Centered Dementia Care
Project Summary/Abstract Dementia poses a significant challenge in the US, with one in three older adults living with the condition. This reality not only incurs staggering healthc...
Molecular Mechanisms of Hormone-Mediated Sex Differences in Wound Healing
PROJECT ABSTRACT Wounds have a sizable impact on public health: 1 out of 50 Americans has a chronic wound at any given time and the cost of wound care exceeds $100 billion per year...
Defining the molecular spectrum of white matter vascular lesions
This project will define the molecular spectrum of white matter vascular lesions that drive vascular cognitive impairment and dementia (VCID).Cerebral small vessel disease (CSVD) i...
Targeting Interindividual Variability in NSAID Responses to Mitigate Chronic Pelvic Pain Risk in Dysmenorrhea
Menstrual pain (dysmenorrhea) is a major cause of distress, disability, and development of chronic pelvic pain (CPP). Very little is known about how local uterine inflammation and...
Natural Language Screening to Improve Early Recognition of Child Physical Abuse in Emergency Care Settings
PROJECT SUMMARY/ABSTRACT This project will test an innovative program of automated screening using natural language processing (NLP) to improve early recognition of child physical...
Characterizing initial recovery from alcohol use disorder and predicting heavy drinking using mobile biosensors
PROJECT SUMMARY/ABSTRACT The overarching goal of this research project is to enhance the understanding and prediction of heavy drinking episodes during initial recovery (IR) from a...
Study of essential genes in Fusobacterium nucleatum
Project Summary: Fusobacterium nucleatum is a significant oral pathobiont associated with periodontal diseases. When it spreads beyond the oral cavity, it is strongly linked to var...
Effects of alcohol on bone remodeling balance in male and female non-human primates and humans
PROJECT SUMMARY Chronic heavy alcohol consumption contributes to high rates of low trauma fractures in middle-aged and elderly populations, especially men. However, low trauma frac...
Repopulation of the Microglia/Macrophage Niche in Experimental Lewy Body Disease
Lewy body disorders are a family of neurodegenerative conditions characterized by deposition of the abundant synapticprotein, α-synuclein, in insoluble cytosolic aggregates. The tw...
Develop a human-mouse chimeric brain model for studying tau pathology in human neuron in vivo
Project Summary/Abstract Alzheimer’s disease (AD) is the most common cause of dementia, affecting 6.7 million Americans aged 65 and older. Tau pathology, characterized by the abnor...
A Cluster-Randomized Control Trial of a Workplace Resilience Intervention for Child Care Providers' Mental Health & Well-Being
ABSTR ACT Work-related stressors take a heavy toll on individuals’ health and well-being as made even more evident by the increased awareness of essential workers during the pandem...
A bio-math approach to elucidate stem cell dynamics in Ceratopteris gametophytes
The development of multicellular organisms raises a key question: how are cell behaviors dynamically controlled to produce tissue and shape? Whether in plants, animals, or humans,...
Multisensory Processing of Alcohol Cues in Young Adult Binge Drinkers
Project Summary In 2022 approximately 61.2 million people aged 12 and older reported binge alcohol use in the past month and young adults ages 18 to 25 represent the highest propor...
Green Synthesis of Building Blocks and APIs by High Hydrostatic Pressure-initiated Synthesis
SUMMARY The current proposal is seeking funding to achieve the fundamental goal of systematically identifying processes that show promise during HHP activation. A broad range of re...