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99,167 grants found
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COMBINATION HIGH-LET MOLECULAR RADIOTHERAPY OF RELAPSED REFRACTORY NEUROBLASTOMA
PROJECT SUMMARY There is a critical need for more effective treatments for metastatic and relapsed neuroblastoma (NB), the most commonly diagnosed extracranial solid cancer in chil...
Interplay between DNA base excision repair and transcriptional regulation
PROJECT SUMMARY Guanine-rich G-quadruplex (G4) forming sequences are enriched at promoter proximal regions of the genome, in particular those of cancer and DNA repair-related genes...
Neural Mechanisms Underlying Cognitive Contributions to Walking as an Early Marker for Risk of Alzheimer’s Disease and Related Dementias
Project Summary/Abstract Early detection of Alzheimer's Disease and Related Dementias (ADRD) is essential for implementing interventions that can slow cognitive decline, benef...
Epigenetic biomarkers of cardiovascular risk in African American Women
ABSTRACT The main goal of this project is to assess the contribution of epigenetics to cardiovascular risk in African American women. Cardiovascular disease substantially impacts A...
Antibiotic Prophylaxis to Prevent Obesity-related Induction Complications in Nulliparae at Term (APPOINT 2.0)
Project Summary/Abstract Obesity increases the risk of pregnancy complications, including puerperal infections and cesarean delivery, and risk rises with increasing body mass index...
Predicting Intervention Outcomes in Reading Disabled Students Using In-School Cognitive Neuroscience
PROJECT SUMMARY/ABSTRACT Reading disability (RD) is the most common neurodevelopmental disorder, affecting approximately 9% of children. Children with RD have significant difficult...
Non-Contrast-Enhanced MRI for Brain Perfusion Mapping of Lewy Body Dementia
Project Abstract Cognitive impairment is a significant non-motor symptom of Parkinson's disease (PD). At least 75% of PD patients surviving for more than 10-years will develop...
Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia - The "NONO trial" - a pragmatic, multi-center, de-implementation, stepped-wedge, cluster-randomized trial
Project summary / abstract Congenital diaphragmatic hernia (CDH) is a complex congenital anomaly where an early embryologic insult disrupts diaphragmatic and pulmonary development,...
Usage of Novel Linked Databases to Improve the Perioperative Management of Patients With Alzheimers Disease and Related Dementias
PROJECT SUMMARY AND ABSTRACT Many patients with Alzheimer’s Disease and Related Dementias (ADRD) undergo surgery. Indeed, patients with ADRD patients account for 25% of patients un...
From traditional medicine to innovation: Discovering novel analgesics targeting calcium modulation from Cameroonian phytochemicals
PROJECT SUMMARY/ABSTRACT There is a pressing need to identify and validate new targets for chronic pain and new sources for novel compounds. This proposal will use novel extracts a...
Dynamic changes in virome-host interactions during pregnancy and postpartum
Abstract For more than a decade the importance of the microbiome and its role in health and disease has been appreciated, yet the virome (the viral component of the microbiome) has...
ATP1A3-Related Disorders in Brazil: Natural History and Antisense Oligonucleotide Therapy Development
Project Summary ATP1A3-related disorders are a group of disorders caused by mutations in the ATP1A3 gene that encodes the α3 catalytic subunit of Na+/K+-ATPase transmembrane ion pu...
Functional characterization of viral-bacterial-human interactions during antimicrobial and inflammatory perturbations across different lifespans
ABSTRACT The gut microbiome (GM) strongly influences human health, playing critical roles in immune priming, nutrient metabolism, and pathogen exclusion. During infant and child de...
Integrative analysis of genomics and proteomics to identify candidate molecular transducers of cardiorespiratory fitness
Project Summary/Abstract: Cardiorespiratory fitness (CRF) is an integrative measure of cardiopulmonary and metabolic health, and a powerful, independent predictor of future risk of...
Localizing Therapeutics to Target Lung Myofibroblasts and Reverse Fibrosis
Project Summary/Abstract Lung diseases are a global public health problem with significant morbidity, inadequate therapies and a very high burden to society. Of these, idiopathic p...
Down Syndrome Early Childhood Omics, Deep Phenotyping, and Epidemiology in Texas: DECODE IT Cohort
ABSTRACT/SUMMARY Down syndrome (DS) is one of the most common genetic syndromes, with a birth prevalence of 1 in 700 that has been increasing in recent years. Children with DS enco...
Using Advanced Imaging to Improve Ex Vivo Lung Perfusion
ABSTRACT / SUMMARY While the number of lung transplantations performed worldwide is steadily growing every year, the number of viable donor lungs remains frustratingly small compar...
Integrated mechanisms of primary and chronic graft dysfunction following lung transplantation
Lung transplantation is increasingly used to treat an expanding list of end-stage lung diseases, resulting in an over >50% increase in the number of lung transplant procedures i...
Core A: Administrative Core
PROJECT SUMMARY – CORE A The goals of the Administrative Core, (Core A), are to provide coordination and integration of all Projects and Cores and within this Program Project Grant...
Core B: Human and Clinical Phenotyping Core
PROJECT SUMMARY CORE B Core B has the overarching goal of supporting the Scientific Projects by providing reliable and readily available clinical data from patients and will suppor...