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99,167 grants found
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Multidisciplinary Characterization of the Gut-Brain Axis in Addiction
Project Summary Addiction and substance use disorders (SUDs) affect more than 27 million people in the United States, with an estimated $740 billion annual cost due to crime, lost...
Towards a comprehensive understanding of the neurotoxic spread of α-synuclein from gut to brain in Parkinson's disease
Parkinson’s disease (PD) is an age-related neurodegenerative disorder for which disease-modifying therapies do not currently exist and the underlying mechanisms remain incompletely...
Engineered cells as agents of arthritis therapy governed by artificial signaling
Project Summary Osteoarthritis (OA), a leading cause of years lost to disability worldwide, is characterized by the breakdown ofthe collagen II-rich matrix of articular cartilage,...
Improving Choice and Use of Biomedical HIV Prevention for Women in Uganda: A Couples-Based Approach
PROJECT SUMMARY/ABSTRACT The HIV prevention field has realized a long-sought goal to have multiple safe and effective HIV prevention options that offer women the opportunity to cho...
Estrogen-mediated effects on neutrophil function and airway inflammatory response
Project Summary Cystic Fibrosis (CF) and nonCF bronchiectasis (NCFB) are characterized by thickened respiratory secretions, chronic lung infection and neutrophilic inflammation. A...
A liver digital twin for personalized cancer therapy
Project Summary/ Abstract Our long-term objective is to improve the efficacy and safety of liver cancer transarterial embolization through new computational tools that enable the d...
The Alama Project: Autism outcomes and neurobehavioral markers in young children born to mothers with HIV in Kenya
PROJECT SUMMARY An estimated 14.8 million children – 90% of whom live in Africa – are HIV-exposed and uninfected (CHEU). Despite advances in understanding health outcomes of CHEU,...
Metabolic Health, Lifestyle, and Risk of Co-Occurring Health Conditions in Down Syndrome (MET-DS)
ABSTRACT Beginning early in life, metabolic dysregulation related to the triplication of chromosome 21(e.g. decreased energy expenditure, increased leptin, hypotonia, increased inf...
Advancing the Lives & HeaLth of Youth and Young Adults with Down Syndrome (ALLY-DS)
PROJECT SUMMARY Endocrinopathies, sleep disorders, cognitive issues, cardiovascular conditions, sensory impairments, and ability differences not only impact the quality of life of...
Determining the Mechanisms of RING1- and YY1-binding protein (RYBP) function and dysregulation in glioblastoma cells
PROJECT SUMMARY / ABSTRACT Glioblastoma multiforme (GBM) is the most common and most lethal tumor of the central nervous system, with a median survival of less than 15 months (Stup...
Lifespan and Cardiovascular Health Effects on The Brain in Humans and Great Ape
Project Summary Humans and great apes share many similarities in age-related illnesses including cardiovascular and cerebrovascular diseases. Nevertheless, critical differences exi...
Examining the Role of Allostatic Load and Neighborhood Disadvantage in Cognitive Function Trajectories among Midlife and Older Black Americans
Project Summary Black Americans are twice as likely to develop Alzheimer’s disease (AD) than White Americans. The biopsychosocial determinants of cognitive function, an early-stage...
Physiological and Behavioral Basis of Circadian Rhythm Delayed Sleep-Wake Phase Disorder
PROJECT SUMMARY/ABSTRACT Delayed Sleep Wake Phase Disorder (DSWPD) is a common circadian rhythm sleep-wake disorder that is characterized by difficulty in initiating sleep at night...
Studies on G-protein coupled receptors that are activated by neuroactive steroids
Abstract. Neuroactive steroids (NAS) such as allopregnanolone (ALLO) are synthesized in the brain from progesterone (P4) and exert potent anxiolytic, anticonvulsant, antidepressant...
1/7-PsycheMERGE: Advancing Precision Psychiatry
PROJECT SUMMARY Psychiatric disorders remain a leading cause of disability in the US and are associated with increased morbidity and mortality. Early detection and treatment is ess...
COMBINI: connecting COmplementary Medicine evidence and BIological kNowledge to support Integrative Health
Project Summary Complementary medicine (CM) approaches are increasingly used by health care consumers, accepted by the medical community, and viewed as a cornerstone of whole perso...
Assessment of germline variants associated with immune-related adverse events following immune checkpoint inhibitors
PROJECT SUMMARY Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but come with the significant downside of immune-related adverse events (irAEs), which can...
Comprehensive Maps of Early Spliceosome and Regulator Binding to Nascent RNA in Human Cells
PROJECT SUMMARY/ABSTRACT We propose to develop new methods for the global identification of protein and RNP interactions with nascent unspliced RNA in human cells. We will use thes...
Integrated Care Plans and Health Care Quality, Outcomes, and Equity for Medicare-Medicaid Dual Eligible Beneficiaries with Multimorbidity, Frailty, or Dementia
PROJECT SUMMARY / ABSTRACT Integrating coverage for dually eligible Medicare-Medicaid beneficiaries (‘duals’), a population with complex medical and social needs, is a national pri...
Rapireon, a new macrocycle molecular glue that selectively activates the nuclease activity of IRE1
The unfolded protein response (UPR) pathway plays an essential role in health and diseases from cancer to neurodegeneration. Of the three UPR pathway branches, the IRE1-XBP1 pathwa...