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99,167 grants found
Showing 581 – 600 of 99,167 grants
Precision imaging of electromechanical coupling for non-invasive cardiac arrhythmia mapping
PROJECT SUMMARY Cardiac arrhythmias are a major cause of morbidity and mortality affecting over 5% of Americans. Arrhythmias have become increasingly prevalent due to an aging popu...
Disease Mechanisms of Early Pulmonary Fibrosis
PROGRAM PROJECT SUMMARY To develop novel, transformative therapies that substantially reduce the burden of morbidity and mortality from progressive pulmonary fibrosis (PF), a funda...
Administrative Core
PROJECT SUMMARY Given the size, complexity, duration, and scope involved, the Administrative Core will be fundamental for enabling the successful establishment and operation of the...
Clinical Core
PROJECT SUMMARY The Clinical and Biospecimen Core (Core A) will support each Project in the Program by implementing all proposed studies involving human research participants. The...
Genomics Core
SUMMARY Single-cell/genomic technologies offer unprecedented opportunities to examine the cellular and molecular mechanisms of disease initiation and progression, predict disease d...
Project 1: Mechanisms of Early Disease Progression in FPF
PROJECT SUMMARY Although there has been substantial progress over the past decade in deciphering the pathobiology of progressive pulmonary fibrosis (PF), a large knowledge gap exis...
Project 3: Functional Genomic Mechanisms of Epithelial Dysfunction in Pulmonary Fibrosis
PROJECT SUMMARY Using single-cell RNA-sequencing (scRNA-seq), we and others have demonstrated dramatic changes in cellular identities, frequencies, and molecular programs that char...
Project 4: Defining the Molecular Natural History of Early and Progressive Pulmonary Fibrosis
PROJECT SUMMARY The advent of single cell RNA-sequencing (scRNA-seq) revolutionized our ability to study the molecular mechanisms underlying pulmonary fibrosis (PF). Our group has...
Project 2: Environmental exposures in pre-clinical FPF
PROJECT SUMMARY Pulmonary fibrosis (PF) is a progressive lung disease that typically presents in older adults who have moderately advanced disease and a limited life expectancy of...
Micro-capsule technology for high-throughput analyses of cell-cell interactions
Project Summary This proposal develops a novel technology to enable analysis of millions and eventually hundreds of millions of live cell-cell interactions in parallel. These tools...
Developing next-generation high-content image-based genetic screens for multi-omic spatial phenotypes
Project Summary/Abstract Spatial organization of the genome, nucleome and transcriptome is key to their control of many essential genomic and cellular functions. Yet existing tools...
Enhancing radioligand therapy for prostate cancer with biomarker and dosimetry guided personalization
ABSTRACT Radiopharmaceutical therapy (RPT) that delivers targeted cytotoxic radiation to cancer cells is typically administered on a fixed activity basis, without personalization,...
MiMA: Mother-infant Metabolite-transporter Atlas
ABSTRACT/SUMMARY The maternal-fetal/infant axis of transport represents one of, if not the highest duration and intimacy of long-distance communication across multi-tissue barriers...
Single Maintenance And Reliever Therapy Strategies for Implementation and Effectiveness Trial
Project Summary / Abstract Asthma is a leading cause of childhood morbidity and disparities nationwide and limited provider adoption of and patient adherence to the prevailing evid...
Neural Circuitry Mechanisms Underlying Maladaptive Reward Memories in Drosophila
PROJECT SUMMARY: Alcohol addiction constitutes one of the most serious public health problems worldwide. According to the CDC, the total economic cost of excessive alcohol use is e...
Can Successful Early Childhood Interventions Sustain Impacts into Middle Childhood? A test from Kenya
Abstract An estimated 43 percent of children under age 5 in low- and middle-income countries (LMICs) will not reach their full developmental potential due to poverty, stunting, or...
The role of PHR signaling in tauopathy-related neurodegeneration
Project Summary Neurodegenerative diseases cause a progressive loss of neuronal function. Currently, an estimated 6 million Americans are live with dementia. Diagnosis often happen...
Myositis-ILD Risk Prediction Models and Endotypes
Interstitial lung disease (ILD) is a highly morbid and potentially fatal complication of myositis. Current myositis phenotypes do not capture significant heterogeneity in ILD clini...
IMProving mobility After revasCularizaTion in Peripheral Artery Disease: the IMPACT PAD Trial
More than 300,000 surgical or endovascular lower extremity revascularization procedures are performed annually for Medicare beneficiaries who have lower extremity peripheral artery...
The pulmonary immune response induced by single and multiple exposures to combustion products of burn pit constituents
Abstract Members of the Armed Services deployed in the Middle East were exposed to numerous environmental toxicants, including emissions from open-air burn pits. Burn pits are desi...