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Showing 4160 of 99,167 grants

Active NON-SBIR/STTR RPGS
Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project
NATIONAL INSTITUTE ON AGING Columbia University Health Sciences United States 2022 – 2027

This U19 proposal focuses on one of the most important, complex questions in Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD) research: What are the deter...

$169.58M
USD
Active NON-SBIR/STTR RPGS
Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project
NATIONAL INSTITUTE ON AGING Columbia University Health Sciences United States 2022 – 2027

This U19 proposal focuses on one of the most important, complex questions in Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD) research: What are the deter...

$168.5M
USD
Active NON-SBIR/STTR RPGS
Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project
NATIONAL INSTITUTE ON AGING Columbia University Health Sciences United States 2022 – 2027

This U19 proposal focuses on one of the most important, complex questions in Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD) research: What are the deter...

$165.01M
USD
Completed NON-SBIR/STTR RPGS
Rho Federal Systems Division, Inc. NIAID DAIT SACCC
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... Rho Federal Systems Division, Inc. United States 2021 – 2023

PROJECT SUMMARY / ABSTRACT The SARS-CoV-2 virus has triggered a world-wide pandemic with over 28 million cases and more than 500,000 deaths in the United States as of March 1, 2021...

$158.44M
USD
Active NON-SBIR/STTR RPGS
The Progressive Supranuclear Palsy Clinical Trial Platform (PTP)
NATIONAL INSTITUTE ON AGING University of California, San Francisco United States 2024 – 2029

PROJECT SUMMARY / ABSTRACT Progressive Supranuclear Palsy (PSP) is a severe neurodegenerative disease of aging that usually leads to death within 5-7 years of diagnosis. There ar...

$157.82M
USD
Completed NON-SBIR/STTR RPGS
Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... University of South Florida United States 2021 – 2025

Project Summary/Abstract The University of South Florida is uniquely qualified to conduct the activities specified in this limited competition RFA. The purpose of the RFA is to f...

$153.2M
USD
Active NON-SBIR/STTR RPGS
ProCAN: Psychosis Risk Outcomes Compound Assessment Network
NATIONAL INSTITUTE OF MENTAL HEALTH Yale University United States 2024 – 2029

PROJECT SUMMARY It has now been two decades since the clinical high risk for psychosis (CHR) criteria were first formulated in service of the goal of preventing psychotic disord...

$149.94M
USD
Completed NON-SBIR/STTR RPGS
CoVPN 3004 - A Phase 3, Randomized, Observer-Blinded, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Immunogenicity of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine Lab
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... Fred Hutchinson Cancer Research Center United States 2021 – 2022

Project Abstract This proposal outlines the scientific agenda for the COVID-19 Prevention Network (CoVPN) Vaccines Leadership Operations Center (LOC) for implementation of the COVI...

$149.8M
USD
Active NON-SBIR/STTR RPGS
An Atlas of Human Brain Cell Variation
NATIONAL INSTITUTE OF MENTAL HEALTH Broad Institute, Inc. United States 2022 – 2027

PROJECT SUMMARY/ABSTRACT The human brain exhibits profound diversity in biological function and vulnerability to disease. Despite the biomedical and cultural importance of inter-...

$149.07M
USD
Active NON-SBIR/STTR RPGS
BRAIN CONNECTS: A Center for High-throughput Integrative Mouse Connectomics
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND S... Harvard University United States 2023 – 2028

Project Summary/Abstract The proposed project will demonstrate the feasibility of generating a complete synapse-level brain map (connectome) by developing a serial-section electr...

$144.97M
USD
Active NON-SBIR/STTR RPGS
Center for Multiomic Human Brain Cell Atlas
NATIONAL INSTITUTE OF MENTAL HEALTH Salk Institute for Biological Studies United States 2022 – 2027

Abstract Understanding cell identities and their spatial distributions throughout different regions of the human brain is a fundamental step when trying to integrate physiologica...

$141.08M
USD
Active NON-SBIR/STTR RPGS
PROVIDENT: Prepositioning Optimized Strategies for Vaccines and Immunotherapeutics against Diverse Emerging Infectious Threats
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... Albert Einstein College of Medicine United States 2024 – 2029

The overarching goal of PROVIDENT (Prepositioning Optimized Strategies for Vaccines and Immunotherapeu- tics against Diverse Emerging Infectious Threats) is to deliver “plug-and-p...

$139.46M
USD
Completed NON-SBIR/STTR RPGS
Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... University of South Florida United States 2021 – 2025

Project Summary/Abstract The University of South Florida is uniquely qualified to conduct the activities specified in this limited competition RFA. The purpose of the RFA is to f...

$138.7M
USD
Completed NON-SBIR/STTR RPGS
Unraveling the earliest phases of vascular cognitive impairment and dementia using CADASIL--a monogenic form of small vessel cerebrovascular disease
NATIONAL INSTITUTE ON AGING University of Wisconsin-Madison United States 2021 – 2025

Project Summary/Abstract The project addresses vascular contributions to cognitive impairment and dementia (VCID) using a design that exploits the enrollment of persons with the au...

$138.29M
USD
Active NON-SBIR/STTR RPGS
An Atlas of Human Brain Cell Variation
NATIONAL INSTITUTE OF MENTAL HEALTH Broad Institute, Inc. United States 2022 – 2027

PROJECT SUMMARY/ABSTRACT The human brain exhibits profound diversity in biological function and vulnerability to disease. Despite the biomedical and cultural importance of inter-...

$137.65M
USD
Completed NON-SBIR/STTR RPGS
Vanderbilt Vaccine and Treatment Evaluation Unit
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... Vanderbilt University Medical Center United States 2021 – 2023

ABSTRACT The goal of this UM1 proposal is to use the remarkable research infrastructure at Vanderbilt University Medical Center and collaborating sites (Washington University, Un...

$133.19M
USD
Active NON-SBIR/STTR RPGS
Precision Aging Network: Closing the Gap Between Cognitive Healthspan andHuman Lifespan
NATIONAL INSTITUTE ON AGING University of Arizona United States 2021 – 2026

SUMMARY/ABSTRACT: Overall Project The strategic vision of the Precision Aging Network (PAN) is to develop the essential scientific knowledge to understand the discrepancy that curr...

$124.72M
USD
Active NON-SBIR/STTR RPGS
Precision Aging Network: Closing the Gap Between Cognitive Healthspan andHuman Lifespan
NATIONAL INSTITUTE ON AGING University of Arizona United States 2021 – 2026

SUMMARY/ABSTRACT: Overall Project The strategic vision of the Precision Aging Network (PAN) is to develop the essential scientific knowledge to understand the discrepancy that cu...

$120.89M
USD
Completed NON-SBIR/STTR RPGS
A People-Centered, Technology-Driven, Scientific Approach to Advancing Conformance with the Voluntary National Retail Food Regulatory Program Standards
FOOD AND DRUG ADMINISTRATION National Environmental Health Assn United States 2021 – 2025

PROJECT SUMMARY After decades of incremental changes to the food safety system, technological advancements have ushered in a corresponding period of increased change for both foo...

$120M
USD
Active NON-SBIR/STTR RPGS
Precision Aging Network: Closing the Gap Between Cognitive Healthspan andHuman Lifespan
NATIONAL INSTITUTE ON AGING University of Arizona United States 2021 – 2026

SUMMARY/ABSTRACT: Overall Project The strategic vision of the Precision Aging Network (PAN) is to develop the essential scientific knowledge to understand the discrepancy that cu...

$119.37M
USD