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99,167 grants found
Showing 41 – 60 of 99,167 grants
Advancing computational modeling of disease metabolism by integrating AI and systems biology
Project summary Metabolic pathways are crucial for cellular energy and function. Dysregulated metabolism is a distinctive feature of various diseases, including cancer, diabetes, c...
Robust Statistical Methods for Longitudinal Microbiome Studies
PROJECT SUMMARY Large-scale longitudinal microbiome studies are increasingly common as they allow investigators to study temporal patterns of the microbiome, elucidating the forces...
Developing synthetic RNA organelles for spatiotemporal separation, control, and monitoring in living cells
Project summary Our understanding of biology is being transformed by the discovery and characterization of organelles arising from the spontaneous phase separation of proteins and...
Vinpocetine Mediation of Prior Fetal Alcohol Exposure
Project Summary/Abstract: There is a compelling need to develop treatments for mental deficiencies from fetal exposure to alcohol. The impairments are often lifelong and while earl...
Studying alcohol-associated liver disease and its interaction with rs738409 variant in PNPLA3 in a liver culture model
PROJECT SUMMARY Alcohol-associated liver disease (ALD), caused by excessive alcohol consumption, is a growing public health problem with a significant impact on the global populati...
Fine-grained Annotation of the Protein Universe through a Community of Practice
PROJECT SUMMARY The functional annotation of proteins is a major bottleneck of biological discovery in the post-genomic era. We are able to accurately generate large swaths of geno...
1/2 Low dose colchicine in pAtients with peripheral artery DiseasE to assess residual vascular risk (LEADER-PAD)
This submission comprises two applications (Clinical and Statistical Data Coordinating Centers). We propose to enroll all 1000 US participants of a planned 6150 multinational parti...
Fecal microbiota transplantation for auto-brewery syndrome
ABSTRACT Auto brewery syndrome (ABS), also known as gut fermentation syndrome, is a rare condition in which a dysfunctional intestinal microbiome produces ethanol, which is absorbe...
Gfastar: a C++ library and a tool suite to aid Telomere-to-Telomere genome assembly
Project Summary The recent completion of a Telomere-to-Telomere (T2T) human genome has demonstrated that, in principle, existing sequencing technologies allow gapless and nearly er...
Hormonal Influences on Inflammation in Endometriosis
ABSTRACT It is estimated that around 10% of reproductive-age women of European ancestry, and 15% of women of Asian ancestry are impacted by endometriosis. In endometriosis, glandul...
MAGNET: MAKING GENOMICS ACCESSIBLE FOR NEWBORNS IN TEXAS
ABSTRACT The great advances made in genomic medicine that impact diagnoses and care of newborn babies in large academic centers in Texas are generally not available at most level I...
Advancing Integrated Treatment for Co-Occurring Opioid and Alcohol Use Disorders: A Comprehensive Analysis of GLP-1 Receptor Agonists and Traditional Pharmacotherapies in Real-World Settings
Project Summary/Abstract The intersection of Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD) presents a significant public health challenge, particularly in clinical setti...
Heart and Lung Outcomes Post-TB (HALO Post-TB)
ABSTRACT: HEART AND LUNG OUTCOMES POST-TUBERCULOSIS (HALO Post-TB) The global prevalence of post-tuberculosis lung disease (PTLD) is estimated to be ~50%, but our understanding of...
External Facilitation to Increase Prescribing of AUD Medications in the Psychiatric Setting
ABSTRACT Patients with major mental illness (MMI; major depressive, bipolar, schizophrenia spectrum, other psychotic disorders; posttraumatic stress disorder) are diagnosed with al...
Serum Exosome Detection and Monitoring of Alcohol-Related White Matter Brain Pathology-Opportunities to Optimize Treatment and Monitoring of AUD-Related Organ and Tissue Damage in Diverse Populations
1 Chronic heavy or binge alcohol consumption damages the brain’s structural and functional integrity. These effects, in large measure, are caused by alcohol’s toxic and degenerativ...
Stem Cell-Derived Microfluidic Placenta Organoids
Project Summary The placenta performs important functions to ensure proper development of the fetus, including oxygen and nutrients exchange, waste product removal and hormone secr...
Synaptic circuit mechanisms underlying psilocybin's therapeutic effects in the stressed brain
PROJECT SUMMARY Psychedelics are chemicals best known for their ability to induce profound changes in the human conscious experience. After a several-decade hiatus, research on psy...
A prospective examination of TAC features as predictors of consequences and alcohol use disorders
PROJECT SUMMARY Young-adult alcohol misuse is a public health problem causing thousands of assaults, injuries, and deaths each year. Both college and non-college adults frequently...
Molecular and Circuit Mechanisms of Neurexin1-Mediated Goal-Directed Dysfunction
PROJECT SUMMARY Studies in humans suggest that Neurexin1α (Nrxn1α), a presynaptically expressed organizer of synaptic structure, is a key genetic risk factor for multiple neuropsyc...
Examining alcohol-induced blackouts in young adults using alcohol sensors
Project Summary Young adult drinking is a major public health problem. Approximately 1 in 3 report frequent heavy episodic drinking (4+/5+ drinks in two hours for females/males). O...