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99,167 grants found
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Prototype Mouse Models for SEND-Based mRNA Delivery and Technology Development
Many human diseases are caused by faulty genes. The best way to treat them is by gene therapy, a concept that has been around for over four decades. One of the major challenges of...
Examining Contextual and Protective Factors on Racial/Ethnic Health Disparities Among Preschool Children with Developmental Delays
ABSTRACT Black and Hispanic preschool children with developmental and disabilities (DD) have endured longstanding disparities in accessing therapies depriving them of services acro...
Contextually responsive implementation of place-activation interventions for promoting physical activity in marginalized urban peripheries in Mexico
Contextually responsive implementation of place-activation interventions for promoting physical activity in marginalized urban peripheries in Mexico PROJECT SUMMARY Background: Mex...
Adversities, Health and Resilience in Early Adulthood: An intergenerational, low-income country study
Over the next 20-years, the number of young adults in Sub-Saharan Africa will increase to 174 million, rendering the health, fertility behaviors and child investments of this cohor...
Longitudinal changes in vascular and autonomic function in premenopausal women with PTSD
Project Summary The ultimate objective of this R03 proposal is to enable Dr. Ida Fonkoue to launch her independent research career by 1) expanding her current K01 research objectiv...
Inter-Generational Cardiometabolic Risk: Explore Underlying Immune Pathways
Abstract Despite decades of concerted efforts, the prevalence of obesity and its associated morbidities such as type 2 diabetes (T2D) and cardiovascular diseases (CVD) continue to...
Personalized Cancer Support for Young Adults
PROJECT SUMMARY Worry and distress in cancer survivors are common, do not correlate with disease severity, and are heightened in young adults who are going through multiple life tr...
XFIT: An Exercise-based Frailty Intervention in Lung Transplant Candidates
PROJECT ABSTRACT Despite major advances in risk stratification and clinical management, the field of lung transplantation continues to experience persistently high waitlist mortali...
Development of diagnostic and prognostic ultrasound imaging biomarkers for plantar heel pain
Project Summary/Abstract Myofascial pain remains an underdiagnosed contributor to a range of musculoskeletal pain conditions. The lack of validated biomarkers limits the ability to...
Integrated spatial omics to elucidate conserved inflammatory mechanisms of vesicant-induced skin injury
SUMMARY Despite significant research and investment, no FDA approved broad spectrum countermeasures are available to rapidly mitigate vesicant-induced injury following intentional...
Novel Biologics to ablate choroid plexus for the treatment of neonatal hydrocephalus
Project Summary Surgical treatment via ventriculoperitoneal shunt or endoscopic 3rd ventriculostomy is currently the most commonly used strategy to treat pediatric hydrocephalus. H...
Uncovering mechanisms of protection from Alzheimer's disease in CHIP using human cohorts and biosamples
Project Summary Aging is associated with outgrowths of mutated blood stem cells, termed clonal hematopoiesis of indeterminate potential (CHIP). The most frequent lesions in CHIP in...
Virtual Mindful After Cancer Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors
PROJECT SUMMARY Sexual concerns are among the most common, distressing, and persistent aspects of life after cancer. For at least half of breast and gynecological cancer survivors,...
Epidemiology and Long-Term Effect of Cardiometabolic Medication Substitution during Post-acute Care
PROJECT SUMMARY/ABSTRACT Nearly 70% of older adults experience medication discrepancy–inconsistencies in medication regimens when they transition from acute hospital to skilled nur...
The Impact of Music Medicine on Preterm Brain Development and Behavior
PROJECT SUMMARY / ABSTRACT Very preterm survivors continue to experience high rates of neurodevelopmental impairment (up to ~60%) after discharge from the neonatal intensive care u...
Acquisition of disability and chronic morbidity by older Indians following extreme urban coastal flooding events
Project Summary Older populations in low and middle income countries are often highly dependent on children and other family members for their economic and physical wellbeing. Elde...
Investigating Feasibility and Acceptability of the FearLess Protocol for Patients with Primary Malignant Brain Tumors and Their Caregivers
PROJECT SUMMARY / ABSTRACT Fear of cancer recurrence (FCR) is alarmingly high among patients with primary malignant brain tumors, who face the certainty of tumor recurrence given t...
Evaluation of Impact of EHR Documentation Assistant Modalities on Provider and System Level Outcomes
Project Summary Over the past decade, there has been a growing epidemic of physician burnout, driven most notably, by Electronic Health Records (EHR), and the increasing amount of...
Investigating the physiological significance of follicular extracellular vesicle miRNAs: From gonadotropin control of biogenesis to application in oocyte vitrification
Project Summary As the average age of first-time mothers in the United States increases, the prevalence of assisted reproductive technologies (ARTs) including oocyte cryopreservati...
Genetically-encoded molecular imaging of genome-edited immune cells
Project Summary Adoptive cell transfers constitute a new paradigm in cell-based therapeutics with wide-ranging applications from neurodegenerative, cardiovascular, autoimmune disor...