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99,167 grants found
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Molecular mechanisms of pituitary plasticity
The anterior pituitary functions as the endocrine core of the organism, regulating hormonal synthesis and secretion to effect adaption to changing metabolic and reproductive needs....
Innovative modeling of the biopsychosocial model in animals: Validation of outcomes for assessing emotional and cognitive domains affected by naturally-occurring chronic pain in dogs
PROJECT ABSTRACT Osteoarthritis (OA) is a major and growing public health problem that negatively impacts quality of life. The prevalence of painful arthritis in the U.S. likely ap...
Functional roles of the human microbiome and metabolome in oral cancer
SUMMARY Head and neck cancer (HNC) remains a lethal disease despite concerted efforts to improve its diagnosis and treatment. Although smoking, drinking, and HPV infection are clos...
Measuring Racial Equity and Institutional Racism in Primary Care (EQUIP)
Abstract: Measuring Racial Equity and Institutional Racism in Primary Care (EQUIP) Disparities in healthcare quality and health outcomes for Black patients compared to White patien...
Neural basis underlying the impact of stress on sleep
PROJECT SUMMARY Stress is associated with insufficient sleep and poor quality sleep. In particular, fragmented non-rapid eye movement sleep (NREMs) due to frequent brief arousals (...
Role of the TE-cGAS-STING pathway in C9orf72-ALS/FTD pathogenesis
Neurodegenerative diseases are characterized by genomic instability, abnormal chromatin relaxation, and transposable element (TE) mobilization, which can harm neuronal function. Ho...
Cellular and molecular mechanisms of dendritic spine growth and stabilization in health and disease
Abstract One of the most remarkable properties of the brain is its ability to undergo adaptive modifications in response to changing environments. This experience-dependent plastic...
Discovery and therapeutic targeting non-coding RNAs in T1D- or T2D-associated atherosclerosis
Despite current therapies and prevention measures, individuals with type 1 diabetes (T1D) experience a disproportionately higher risk of cardiovascular events due to a more severe...
CSF Oligomeric α-synuclein targeted nano scavengers as a Parkinson's disease theranostic
Project Summary The pathogenesis of Parkinson’s disease (PD) and related synucleinopathies such as dementia with Lewy bodies are characterized by progressive deposition Lewy bodies...
Unraveling the Role of Clonal Hematopoiesis in Neurodegenerative Diseases
ABSTRACT Clonal hematopoiesis (CH) has been linked to an increased risk of cancer and cardiovascular diseases. However, its potential implications in various age-related conditions...
Preclinical Modeling of Neural Regulatory Networks in Baboon Epilepsy
PROJECT SUMMARY Genetic generalized epilepsies (GGE) are the major subtype of epilepsy syndromes, accounting for about 40% of U.S. cases. Contrary to popular belief, over one-third...
Perturbation-response approaches to determining the regulatory networks underlying human complex traits
Project Summary/Abstract A large majority of heritable human traits and diseases are complex, with genetic variants of small effect spread throughout the genome. It is now understo...
VCID CWOW: Identifying Novel Targets to Treat Cerebral Amyloid Angiopathy
Alzheimer’s disease (AD), most common form of dementia, affects over 55 million people worldwide. Numbers are expected to double every 20-years unless improved treatments are devel...
Vasculo-neuronal pathophysiological interface in Alzheimer’s and Atherosclerosis
Cardiovascular disease has emerged as a significant contributor to cognitive impairment, operating both independently and as a catalyst for the progression of Alzheimer’s disease (...
Deciphering the structural basis of repeat-associated non-AUG (RAN) translation in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Expansion of a hexanucleotide GGGGCC repeat within the first intron of the C9orf72 gene is the primary monogenic cause for both Amyotrophic Lateral Sclerosis (ALS) and Frontotempor...
Generation of intersectional genetic tools for advancing tendon and musculoskeletal research
Project Summary Tendon and ligament injuries are widespread and affect young active to aging individuals. Once injured, tendons undergo slow and limited healing and never regain th...
Talking with Small Molecules: Corynebacteria in the Human Microbiome
Project Summary & Abstract Bacteria communicate with their environment using a chemical language consisting of secreted small molecules, also referred to as natural products or...
Using gene expression to identify patients at high risk for late breast cancer recurrence
PROJECT SUMMARY Non-metastatic breast cancer is treated surgically and with adjuvant therapies. As these treatments have improved, recurrence-free survival has steadily increased,...
Brain Development in Down Syndrome during Fetal and Early Postnatal Ages
Abstract Down syndrome (DS), or trisomy 21, is the most common chromosomal disorder in newborns (about 1 in every 700 babies in the United States). Associated with numerous impairm...
Building and Validating Lifelong Self-Management Capacity with Advanced AI: MyMSMentor
PROJECT SUMMARY In 2018, 51.8% (129 million) of American adults had at least one chronic condition (e.g., diabetes, arthritis). The total cost of chronic conditions is $3.7 trillio...