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Whole genome sequencing analysis of hidradenitis suppurativa
Project Summary Hidradenitis suppurativa (HS) is a multifactorial chronic, debilitating, inflammatory skin disorder characterized by painful nodules, abscesses, sinus tracts, and s...
Advancing breast cancer risk assessment for Black women
ABSTRACT Effective treatment schemes have reduced breast cancer mortality, but precise identification of women at increased risk of developing breast cancer, to personalize screeni...
Theta burst subthalamic nucleus deep brain stimulation for cognitive and motor improvements in Parkinson's Disease
Lewy body dementia (LBD) is the second most common cause of dementia after Alzheimer’s disease. In particular, Parkinson’s Disease (PD) progression has been associated with LBD and...
Probing Biomolecular Condensates in Live Cells using Microsecond-scale Single Molecule Rotational Diffusion Microscopy (µs-SiMRoD)
PROJECT SUMMARY The crowded conditions within cells present a complex physicochemical challenge for maintaining the solubility and fluidity of thousands of distinct macromolecules....
Virtual Twin-Powered Rapid Development of Bioactive Multifunctional Dental Restoratives
Summary There is a global need to prioritize the development of a novel dental restoration that meets the criteria of being long-lasting, easy to use, and accessible without compli...
Myeloma multidimensional precancer atlas
SUMMARY Multiple Myeloma (MM) is almost always preceded by monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM), with a transformation rate of ~1%...
Revealing novel mechanisms of gout flares by transcriptional phenotyping synovial and peripheral blood mononuclear cells.
Gout is the most common inflammatory arthritis, but beyond the well described role of the NLRP3 inflammasome, the molecular genetic causes of gout flares is least well known among...
The Impact of Gender Affirming Hormone Therapy on Pain in Gender Minority Adults
PROJECT SUMMARY In most chronic pain syndromes there is a 1.5-2 times higher incidence in females compared to males after puberty, which may in part be due to differences in sex ho...
Aberrant chromatin regulatory mechanisms in Down syndrome brain
PROJECT SUMMARY Down syndrome (DS) is the most common form of autosomal aneuploidy in humans, with an incidence of ~1 in 700 live births, and is characterized by physical growth de...
Quantification of Distraction in Academic settings: A Translational Approach
Distractibility poses a significant public health concern for our youth, due to the seemingly never-ending barrage of visual and auditory stimulation in our real-life and digital e...
SCH: AI-empowered wearable multimodal sensors (AI-MEDALLION) for noninvasive monitoring
Over the last decade, significant progress has been made in wearable sensors that detect biomarkers in a continuous and non-invasive manner from biofluids such as sweat. Parkinson&...
Immunometabolism and the Cardio-Renal Axis in T1D-associated Atherosclerosis: Insights from the CaRe T1D Biobank
Abstract Cardiovascular disease (CVD) caused by atherosclerosis remains the leading cause of mortality in individuals with type 1 diabetes (T1D). Although T cells are well known to...
Molecular Drivers of Atherosclerosis in Diabetes
PROJECT SUMMARY The mortality rate among individuals with type 1 diabetes (T1D) remains significantly elevated due to cardiovascular complications, highlighting a critical need for...
Spatial Proteomics of osteoarthritis in bones to uncover disease progression
PROJECT SUMMARY / ABSTRACT There is an urgent need to develop novel and innovative technologies to advance health and therapeutic interventions and to develop tools for monitoring...
MICRORNA REGULATION OF ADIPOSE TISSUE IMMUNE RESPONSE IN OBESITY
Project Summary Obesity cultivates complex immune responses in white adipose tissue (WAT), which may contribute to the development of insulin resistance and type 2 diabetes mellitu...
Substance P Metabolites and Receptors in the Pathogenesis of Cardiac Disease in Type 1 Diabetes
Cardiovascular disease is the leading cause of death in patients with type 1 diabetes (T1D). A key cardiovascular outcome is left ventricular remodeling in the form of concentric h...
Characterization of risk factors for excessive cardiovascular diseases (CVD) from circulating and cardiovascular tissues of people with well-controlled chronic type 1 diabetes
Abstract People with Type 1 diabetes (T1D) have excessive risks for cardiovascular diseases (CVD), even when they have well-controlled traditional CVD risk factors, such as hyperte...
Single-cell, multi-omic investigation of epicardial adipose and coronary endothelial dysfunction in type 1 diabetes
Abstract Cardiovascular disease (CVD) is the leading cause of mortality in patients with Type 1 Diabetes (T1D), driven by complex pathophysiological dysfunctions that remain poorly...
Optimizing Treatment of Co-occurring Smoking and Unhealthy Alcohol use among PWH in Nairobi, Kenya
Project Summary. Sub-Saharan Africa is home to >70% of people with HIV (PWH) globally. It is also burdened with rising rates of tobacco use, high rates of unhealthy alcohol use,...
Diversity Supplement to Mechanisms Regulating Lung Injury and Early Lung Fibrosis
ABSTRACT The overall goal of this Program is to understand the role of MUC5B in establishing a vulnerable lung and the transition of a vulnerable lung to a lung characterized by pe...