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99,167 grants found
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Integrated analysis of HBV-specific CD4 T cell and B cell responses to define their role in chronic hepatitis B and HBV functional cure.
Project Summary The overarching goal of this multi-PI R01 proposal is to identify the mediators of functional cure of hepatitis B virus (HBV) infection in the cellular and humoral...
Deep Behavioral Phenotyping of Novel Zebrafish Epilepsy Models
Project Summary/Abstract Patients diagnosed with genetic epilepsies suffer with severe seizures, neurobehavioral deficits and the uncertainty of a lifetime with diminished quality-...
A translational study of a synthetic lethality interaction of CD105 and androgen receptor signaling axis for castration-resistant prostate cancer patients
The goal of this proposal is to better understand a novel signaling axis initiated in prostate cancer (PCa) patients by next-generation androgen receptor signaling inhibitors (ARSI...
Understanding mechanisms of BTK inhibitor and degrader resistance in patients with chronic lymphocytic leukemia
Project Summary Covalent inhibitors of Bruton’s tyrosine kinase (BTK) are effective in multiple B-cell malignancies but patients discontinue these agents due to resistance and into...
Mechanisms of Fetal Skin Regeneration
The ability to regenerate complex, multi-lineage organs remains one of the key challenges in regenerative medicine. Many mammalian organs, including the heart, digit tip, and skin,...
Leveraging Large Linked Datasets and Novel Analytic Methods to Understand the Long-term Effectiveness and Value of Cardiac Rehabilitation in Understudied Populations
PROJECT SUMMARY Cardiac rehabilitation (CR) combines supervised exercise, risk factor modification, and psychosocial support in a structured program that may lower cardiovascular m...
Residential Segregation and Physiological Dysregulation among Black CARDIA participants: A Longitudinal Study
PROJECT SUMMARY/ABSTRACT Although research linking race-based residential segregation to health outcomes has been conducted for decades, there is currently a lack of understanding...
Mechanisms of RUNX1 transcriptional control in hematopoiesis
PROJECT SUMMARY/ABSTRACT Germline loss-of-function mutations in the RUNX1 gene cause a familial platelet disorder with a predisposition to the development of myeloid malignancy (RU...
Physiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest (PEDICA)
Project Abstract Pediatric in-hospital cardiac arrest (IHCA) occurs in >15,000 children annually in the United States, most of whom do not survive to hospital discharge. As less...
Multispectral imaging of bile duct epithelial morphology for early detection of malignancy
Project Summary Bile duct cancer, also known as cholangiocarcinoma, is the second most common primary liver cancer. It is considered to be an incurable cancer with no identifiable...
Oscillatory Recurrent Gated Neural Integrator Circuits (ORGaNICs): a unified framework for neural dynamics and human cognition
Project Summary/Abstract There is considerable evidence that the brain relies on a set of canonical neural computations, repeating them across brain regions and modalities to apply...
Breastfeeding intervention to prevent obesity among Latine children
Project Summary Due to high rates of obesity, Latine children are more likely to have type 2 diabetes (T2D) than other racial/ethnic groups. If current trends continue, it is estim...
Genetically-engineered Bacteria Overcome Therapy Resistance
Project Summary: For this proposal in response to PAR-22-085: Microbial-based Cancer Imaging and Therapy - Bugs as Drugs, we will focus on metastatic pancreatic ductal adenocarcino...
Role of RNA-binding protein DDX3X in heart development and disease
PROJECT SUMMARY The relatively finite number of ~20,000 protein coding genes in the mammalian genome limits the overall diversity that transcriptional regulation can achieve in a g...
FOG2 isoforms in Coronary Microvascular Disease
PROJECT SUMMARY Coronary Microvascular Disease (CMVD), defined as disease of the coronary pre-arterioles, arterioles, and capillaries, accounts for 30-50% of the burden of Ischemic...
Molecular pathways that strengthen GABAergic inhibition and reduce seizure susceptibility
PROJECT SUMMARY The proposed project will fill an important knowledge gap in the field by providing a mechanistic understanding of how FLT3 signaling regulates neuronal function an...
Targeting metabolic stress response to improve CAR-T cell efficacy.
Project Summary T cell-based immune therapies are a promising approach to treat cancer. Chimeric antigen receptor (CAR) is one such therapy developed by engineering a protein compr...
Elucidating Cholinergic Relationships with Psychosis And Cognitive Deficits in Schizophrenia
PROJECT SUMMARY / ABSTRACT Schizophrenia (SCZ) is among the most severe and disabling medical conditions worldwide, yet the brain alterations that lead to the symptoms of SCZ remai...
Reducing toxicity from prostate cancer radiotherapy through genetics and technology
PROJECT SUMMARY/ABSTRACT There is an incredible need to find new biomarkers to improve our ability to personalize cancer therapy, to identify those that will have toxicity from tre...
Unravel the novel role of S100A7 and its functional partners in Metastatic Triple Negative Breast Cancer Racial Disparity
Triple-negative breast cancer (TNBC) disproportionately affects African American (AA) women, with mortality rates 65% higher than Caucasian (CA) women. The mechanisms underlying th...