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99,167 grants found
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Long-range coordination of planar polarity
Project Summary The highly conserved Planar Cell Polarity (PCP) pathway is essential for cells to communicate directional information between neighboring cells to drive collective...
Role of codon usage bias in eukaryotic evolution and regulation
PROJECT SUMMARY Codons and tRNAs are key components of the central dogma, and changes in the abundance of either can lead to significant cellular changes. While perturbations of th...
Resolving cellular functions of arginine methylation
Summary PRMT5 is an essential enzyme and the cell’s primary enzyme capable of symmetric dimethylation of arginine residues. PRMT5 is a therapeutic target in cancer and neurodegener...
Combining soluble and bound factors in microstructured hydrogels to promote chronic wound angiogenesis and healing
PROJECT SUMMARY Soluble and bound factors play a pivotal role in cell signaling, adhesion, and function to promote wound angiogenesis and healing. Depending on the content of how t...
Leveraging cell-instructive hydrogels to understand microenvironmental impact on wound healing processes
Abstract: Wound healing after injury is accomplished by the coordinated action of several cell types that migrate to the injury region and participate in tissue repair. Interaction...
Translational approaches to unravel organ-specific microvascular endothelial responses in sepsis.
Translational approaches to unravel organ-specific microvascular endothelial responses in sepsis. PROGRAM SUMMARY: Sepsis is defined as life-threatening organ dysfunction caused by...
Evolution of 3D Genome Folding Mechanisms and Gene Regulatory Strategies in Metazoans
Evolution of 3D Genome Folding Mechanisms and Gene Regulatory Strategies in Metazoans Abstract: The overarching goal of this project is to elucidate the role that 3D genome folding...
Uncovering the Molecular Determinants of Metastatic Recurrence and Impaired NK Cell Function
PROJECT SUMMARY Our proposed research employs innovative, unbiased approaches and novel preclinical models to elucidate how disseminated HER2+ breast cancer cells cells survive in...
Utilization and Clinical Outcomes of Left Atrial Appendage Occlusion in Older Adults with Atrial Fibrillation and Frailty
PROJECT SUMMARY One in every 3 persons develops atrial fibrillation (AF) in their lifetime, and AF affects at least 10% of adults aged ≥65-years. Stroke prophylaxis with oral antic...
Deciphering Occupational Asthma Pathogenesis Caused by Isocyanate
Diisocyanates are crucial ingredients in many important products and industries (i.e. construction, automotive, aerospace, medical, military/civilian). Recognized in 1951 as occupa...
Peripheral mechanisms of exercise intolerance in HFpEF
Project Summary/Abstract: The hallmark features of heart failure with preserved ejection fraction (HFpEF) are exercise intolerance and exertional symptomology. It is now clear that...
mRNA Nuclear Export Machinery as Target of SARS-CoV-2 Nsp1 Protein
The global COVID-19 pandemic caused by the SARS-CoV-2 outbreak underscores the need for understanding viral-host interactions that impact host gene expression and antiviral respons...
Neuron-specific modulation of gene expression using systemically administered bispecific antibody-ASO conjugates
The ability to selectively modulate the expression of one or more neuronal genes is critical for defining pathways that govern normal brain physiology and diverse disease phenotype...
Targeting Senescence and the senescent secretome to impact breast cancer formation
Project Summary Senescence and the senescence associated secretory phenotype (SASP) have long been implicated in driving tumorigenesis. However, the pro-tumorigenic mechanism(s) of...
Tissue Mechanisms of Aging in the Genetic Model C. elegans
Project Summary/Abstract The nematode C. elegans is a leading experimental and genetic model for aging, and both public and private institutions have made enormous investments in a...
Optimizing Theranostic Dosimetry and Kidney Biomarkers for Alpha-Emitter Radioligand Therapy in Neuroendocrine Tumors
SUMMARY The somatostatin subtype 2 receptor (SSTR2) is expressed in 80-100% of NETs. SSTR2 targeted alpha-emitter radioligand therapy (α-RLT) is emerging as an exciting alternative...
Reprogramming of hematopoietic stem cells during contact with the perivascular niche
PROJECT SUMMARY/ABSTRACT Hematopoietic stem and progenitor cell (HSPC) transplantation is a curative treatment for many blood diseases and cancers. However, these procedures still...
Novel Roles of Protein phosphatase 2A in Cardiac Arrhythmia
Project Summary Sudden cardiac death and arrhythmias account for ~15-20% of all deaths worldwide. Voltage gated sodium channels (Nav) in heart are major regulators of myocyte excit...
Dietary impacts on organismal health through altering epigenetic silencing of transposable elements
PROJECT SUMMARY Transposable elements (TEs) are widespread genomic parasites that occupy nearly half of the human genome. The selfish replication and movement of TEs are generally...
Building a kidney monitoring panel to guide therapy in resistant hypertension
PROJECT SUMMARY Hypertension (HTN) is the most common risk factor for cardiovascular disease (CVD) and causes multiple health problems including stroke, heart failure, kidney failu...