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99,167 grants found
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Neuronal regulation of tissue-resident macrophage maintenance and polarization
PROJECT SUMMARY The barrier tissues and body cavities are densely innervated by nociceptor sensory neurons (or nociceptors) that respond to noxious stimuli and mediate pain. Nocice...
Mechanistic Studies of Genome Folding
Project Summary Overview: During interphase, the cohesin complex extrudes chromatin loops to mediate the formation of chromatin domains and loops, which are elementary 3D structure...
Epigenetic control of behavior
PROJECT SUMMARY / ABSTRACT Societies are organized into hierarchies, which fundamentally involve social conflict. As a result, there are winners and losers, and social defeat can p...
Ni-catalyzed sustainable and scalable approaches to nitrogenated compounds
Abstract: This proposal describes the development of sustainable methodologies using Earth-abundant Ni-based catalysts to synthesize nitrogen-containing molecules. The proposed pro...
Deciphering the Stepwise Regulatory Mechanisms of Genome Folding
Deciphering the Stepwise Regulatory Mechanisms of Genome Folding In multicellular organisms, the precise regulation of gene expression across the different cell types and developme...
Cellular and Molecular Mechanisms of Regenerative Growth and Repatterning
Project Abstract Regenerative abilities vary significantly both between different species and between distinct tissues of a given species. Despite recent advances, many fundamental...
Predicting Endocrine Therapy Response In Male Breast Tumors
PROJECT SUMMARY/ABSTRACT Male breast cancer is critically understudied due to both the rarity of the disease and the exclusion of men from breast cancer trials leading to a signifi...
The genetic and evolutionary mechanisms underlying the origins of new molecularfunctions
SUMMARY The molecular basis by which a new function emerges in evolution sets the mechanisms by which it can break down – ultimately contributing to disease. Unfortunately, our und...
Molecular mechanisms in the mammalian cell nucleus
Abstract/Project Summary My research group strives to gain detailed information about cellular nanoscale structures, dynamics, and molecular mechanisms by designing and applying in...
Increasing Use of SNAP Fruit and Vegetable Incentive Programs for Families with Food Insecurity
The Supplemental Nutrition Assistance Program (SNAP) has financial incentive programs where families in SNAP can purchase fruits and vegetables (F&V), for half the price or les...
Investigating supernumerary chromosome biology using the B chromosome model system
Humans have a defined set of chromosomes that are essential for our normal growth, development, and reproduction. Carrying too many (or too few) copies of these essential chromosom...
Selective inhibitors of MLCL/CytC Peroxidase in Barth Syndrome
Barth syndrome (BTHS) is an X-linked disorder characterized by cardio- and skeletal myopathy, neutropenia, and mitochondrial dysfunction, which limit the quality of life for BTHS p...
Dissecting mechanisms of collective migration
PROJECT SUMMARY Background: Collective migration is a type of cell migrationwhere groups of cells move together in a coordinated fashion that is essential for development and disea...
Mechanisms of epigenetic memory in human cells
Project Summary/Abstract Almost every cell in a human being has the same DNA sequence yet different cells vary widely in which genes are expressed. In addition to the genetic code,...
Regulation of hematopoietic stem cell niche aging by the sympathetic nervous system
PROJECT SUMMARY: Hematopoietic aging is associated with a decline in the regenerative capacity of hematopoietic stem cells (HSCs), leading to the development of blood disorders and...
Systemic Enzyme Delivery by a Brain Targeted SapC-DOPS Nanocarrier for Treatment of Neuronopathic Gaucher Disease
Summary Gaucher disease (GD) is a common lysosomal storage disease, occurring at a rate of 1 in 500 in Ashkenazi Jews and 1/60,000 in the general population. Defective acid β-gluco...
Microglial-serotonin interactions in the developing brain.
Summary of Work Decades of research have strongly linked disruptions in the serotonin (5HT) system to mental health disorders such as depression, and social and communication diffi...
Rapid Culture-Independent Detection of Sepsis Causing Microorganism Directly from Blood
ABSTRACT Sepsis is a rapid-developing and life-threatening condition and is one of the most common causes of death in hospitalized patients in the US. Sepsis is generally caused by...
Enzymatic Determinants of Gut Microbial Metabolic Biotransformations
PROJECT SUMMARY/ABSTRACT The human gut is a complex ecosystem, where trillions of microbes interact with dietary and host-derived molecules, mediating biotransformations that signi...
Postnatal transient connectivity in brain development and implications in fragile x syndrome
ABSTRACT Fragile X syndrome (FXS) is the most common genetic cause of autism spectrum disorders. Autism symptoms in FXS patients typically manifest during early infancy when childr...