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99,167 grants found
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Role of chromatin mechanics in nuclear shape and integrity
Project Summary Abnormal nuclear shape is a diagnostic marker of disease progression and contributes to cellular dysfunction. Perturbations to major nuclear rigidity components, ch...
Unraveling the physiological and metabolic impacts of a universal metabolite repair enzyme that removes a strong inhibitor of the TCA cycle
PROJECT SUMARY / ABSTRACT In general, enzymes are very precise at catalyzing a specific canonical reaction that fits within a particular metabolic network. Still, no enzyme is a pe...
PreventT2 Together: Examing the efficacy of couple-based lifestyle intervention to prevent type 2 diabetes
PROJECT SUMMARY/ABSTRACT Nearly half of U.S. adults have or are at risk of developing type 2 diabetes. Lifestyle intervention is efficacious and the first line of prevention among...
Advancing Endovascular PAD Treatment: Overcoming Critical Knowledge Gaps with MRI-histology
ABSTRACT Peripheral artery disease (PAD) causes severe morbidity as plaques obstruct blood flow, preventing adequate perfusion to limbs, which may result in amputation or death. Th...
Structural and mechanistic basis for the maturation of site-one protease in the secretory pathway
PROJECT ABSTRACT Site-one protease (S1P) is a membrane anchored protease in the secretory system and a critical component of cellular signaling pathways including cholesterol bioge...
Optimization of a behavioral intervention to increase physical activity in older adults living with HIV
Age is the largest risk factor for dementia and cognitive decline. Many people living with HIV (PLWH) are aging and at risk for Alzheimer Disease and Related Dementias (ADRD). Phys...
Understanding type IV pili on the singe-molecule level
Type IV pili (TFP) are captivating bacterial nanomachines that are broadly conserved and exhibit a diverse array of physiological functions. In the opportunistic pathogen Pseudomon...
Roles for endoplasmic reticulum associated degradation (ERAD) in Myocardial Proteostasis
Proteostasis comprises the processes governing the life cycle of proteins from synthesis to degradation. Imbalanced proteostasis contributes to numerous pathologies, including thos...
The functional and phenotypic effects of protein coding genetic variation
PROJECT SUMMARY/ABSTRACT My lab develops statistical methods to characterize genetic architecture and to translate genetic data into biological insights. We are broadly interested...
Long-term population-level impact of a school-based parenting-focused intervention to prevent obesity among Black and Latinx children in historically disinvested neighborhoods
Project Summary/ Abstract Children with obesity are at increased risk of cardiovascular disease, type 2 diabetes, and premature death. Black and Latinx children are more likely tha...
Formation and Repair Mechanisms of DNA-Protein Cross-Links, and Functions and Regulatory Mechanisms of TREX1 in DNA Repair
Abstract Understanding how DNA is damaged and how the damage is repaired is critical. This is because DNA damage contributes to genome instability, aging, and diseases, and DNA-dam...
Co-evolutionary dynamics between transposable elements and their hosts
Project Summary Genome stability is necessary for fertility and health. Transposable elements disrupt genome stability by selfishly replicating within host genomes, producing inser...
Mechanisms of chaperone-mediated proteasomal degreadation
Project Summary/Abstract My research program is focused on the intersection of pro-folding chaperones and the pro-degradation 26S proteasome. Protein Quality Control (PQC) is the b...
A generalizable platform to identify cellular mechanisms that enhance secretory efficiency
Project Summary / Abstract The long-term goal of my lab is to better understand cellular mechanisms that regulate secretory granule maturation, efficient packaging of hormone, and...
Characterizing bioelectrical signaling between the gut microbiota and the host
PROJECT SUMMARY/ABSTRACT Cellular communication is a complex interplay of biochemical, biophysical, and bioelectrical signaling. Beyond well-known neuronal action potentials, vario...
Mechanisms of membrane tethering in autophagy
Project Summary/Abstract Cells are in a constant battle to maintain homeostasis and respond to stress. Autophagy is a conserved eukaryotic pathway that responds to cellular stresse...
Development of fast diffusion magnetic resonance fingerprinting of the prostate to avoid unnecessary biopsies
Abstract The most common malignancy for men in the western world is Prostate cancer (PCa), with a predicted 288,300 new cases and 34,700 specific deaths in 2023. With recent develo...
Mitigating Hematologic Adverse Events in Patients with Myeloid Malignancies: A Novel Causal Artificial Intelligence Approach
PROJECT SUMMARY/ABSTRACT Thrombosis and bleeding are the major causes of morbidity and mortality among survivors of myeloid malignancies. Previous studies proposed clinical and lab...
Cell cycle control of cellular metabolism through phase-specific regulation of mTOR Complex 1
Project Summary/Abstract Cellular metabolic and biosynthetic demands change throughout the cell cycle, which critically impacts cell growth, proliferation, and human disease. Under...
Chemoenzymatic Synthesis of Libraries of Sulfoglycopeptides
Abstract The Zhu lab uses synthetic chemistry to answer questions related to post-translational modifications (PTMs) of proteins, specifically, O-glycosylation and Tyrosine sulfati...