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99,167 grants found
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High-throughput assessment of chemotherapy-induced cardiotoxicity in 3D human cardiomyocytes
High-throughput assessment of chemotherapy-induced cardiotoxicity in human cardiospheres Project Summary Chemotherapeutic agents including both traditional drugs (e.g., anthracycli...
Leukotriene B4 Regulation in Heart
PROJECT ABSTRACT Patients with type 2 diabetes (T2DM) are at increased risk (~50%) relative to non-diabetic individuals of suffering sudden cardiac death (SCD), most often due to f...
Microbiota-Immune Interactions in CTLA-4 Antibody Blockade-Induced Colitis
Abstract Monoclonal antibodies targeting CTLA-4, PD-1, and PD-L1 are widely used to promote anti-tumor immune responses in a range of human cancers, but can also lead to inflammato...
Metabolic control of beta-cell secretory organelle function
Compelling evidence highlights the central role of islet β-cell failure in the transition from insulin resistance to Type 2 diabetes (T2D). Defects in the β-cell's secretory p...
Assessment of the Impact of antihypertensive Medications on vascular and renal outcomes in Chronic Kidney Disease (AIM-CKD)
Title: Assessment of the Impact of antihypertensive Medications on vascular and renal outcomes in Chronic Kidney Disease (AIM-CKD) Abstract Chronic kidney disease (CKD), characteri...
Mapping RNA Binding Protein Interactions Within Cellular Microenvironments
PROJECT SUMMARY RNA binding proteins (RBPs) play critical roles in all aspects of RNA metabolism, with significant implications in physiological and pathological settings. A crucia...
Randomized Controlled Trial of a Hybrid-Delivered Cognitive Behavioral Symptom Management and Activity Coaching Intervention for Stem Cell Transplant Patients
Our objective is to use novel mobile health (mHealth) behavioral intervention approaches to enable patients who have undergone hematopoietic stem cell transplant (HCT) to effective...
Hosts Going Viral: Building The Tools And Systems To Determine How Human-Relevant Biology Evolved Through The Capture Of Viral Genes In Our Distant Ancestors
SUMMARY: Acquiring extracellular genetic and functional novelty can forever change the evolutionary trajectory of organisms, from mitochondria to antibiotic resistance to placental...
Critical roles of RNA m5C-MBD6-H2AK119ub deubiquitylation axis in TET2-mediated HSC regulation
Abstract TET2 is commonly mutated in adult myeloid malignancies and normal individuals with clonal hematopoiesis. TET2 plays an important role in the regulation of hematopoietic st...
Defining the mitochondrial metabolic regulation of systemic innate inflammation
PROJECT ABSTRACT The interplay between metabolic and inflammatory processes is critical to maintaining overall health where a delicate balance exists between pathogen clearance and...
Development of Chimeric Antigen Receptor Phagocytes Against Glioblastoma
Project Abstract: Pediatric HGGs comprise glioblastoma [glioblastoma multiforme (GBM)], anaplastic astrocytoma, and diffuse intrinsic pontine glioma (DIPG) and collectively are the...
Addressing perceived social isolation as a novel therapeutic target among individuals with OUD using telehealth CBT
Perceived social isolation—commonly known as loneliness—is a psychosocial stressor that is associated with increased mortality, opioid use, and precipitants of relapse among indivi...
Mechanisms of Translational Dysregulation in Huntington disease
This investigation aimed to identify the mechanisms and molecular functions of ribosome stalling in Huntington disease (HD). HD is caused by the polyglutamine (CAG) expansion of hu...
STUDIES ON FATTY ACID METABOLIZING CYTOCHROME P450 ENZYMES
PROJECT SUMMARY AND ABSTRACT Cytochrome P450 enzymes (P450, CYP) are essential for the metabolism of xenobiotics and endobiotics. The CYP4F family of fatty acid -hydroxylases cons...
Genetic analysis of signaling pathways in cilia assembly and remodeling
PROJECT SUMMARY Primary cilia mediate transduction of all major signaling pathways, which in turn modulate cilia morphology and functional outputs. The research in my lab is focuse...
Using Inorganic Chemistry to Understand and Solve Health-Related Problems
Project Summary. This award is sought to support the foundation of a research program that will broadly capitalize on the unique properties of inorganic compounds to afford medicin...
Regulating parenchymal repair in wound healing
Project Summary Many tissues in adult mammals are incapable of regeneration after injury because the parenchymal cells that provide the specialized tissue functions lack sufficient...
Identifying mechanisms underpinning epigenetic homeostasis
PROJECT SUMMARY DNA methylation is important for gene regulation, transcriptional silencing of repetitive DNA and establishing genomic imprinting. While DNA methylation is a dynami...
Molecular mechanisms of RNA methyltransferases.
Project Summary. This R35 MIRA application concerns investigating the structure, function, and regulation of two mRNA methyltransferase enzymes: RNA (guanine-N7) methyltransferase...
Switchable Organometallic Catalysts for Organic Reaction Development
Project Summary / Abstract The discovery of new catalyzed methods to generate key bonds in organic molecules is vital to the sustainable synthesis of biologically relevant molecule...