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99,167 grants found
Showing 5,241 – 5,260 of 99,167 grants
Time-Dynamic Tree-Based Methods for Personalized Alzheimer's Disease Prediction
Project Summary (Abstract) This two-year grant proposal responds to PAR-23-179, and its long-term goal is to advance the understanding of biomarker in relation to preclinical Alzhe...
Lamin A/C is required for maintaining subsynaptic myonuclei integrity
Project Summary / Abstract Sarcopenia, the age-related decline in skeletal muscle mass and force, is characterized by muscle wasting and diminished contractile strength leading to...
The epigenetics of dementia risk in the Million Veteran Program
Alzheimer’s disease and related dementias (ADRD) affect approximately 10% of the US population, with prevalence increasing with age (e.g., 3% between ages 65–74 to 32% for people o...
The impact of cholecystokinin on pancreatic beta-cell survival through paracrine and pharmacologic signaling
Diabetes affects nearly 1 in 4 Veterans receiving care from the VA. Reduced b-cell mass and increased b-cell apoptosis are key to the pathophysiology of both type 1 and type 2 diab...
Over-the-Counter PrEP: Acceptability, Feasibility, and Potential Impact of Access without a Prescription (OFFSCRIPT)
PROJECT SUMMARY The population-level impact of HIV preexposure prophylaxis (PrEP) has been limited by barriers to access. People face challenges with attending frequent clinical vi...
Virtual Reality Treatment for Chronic Pain and OUD In Opioid Treatment Programs: A Randomized Controlled Trial
PROJECT ABSTRACT Over half of the 6 million persons with opioid use disorder (OUD) in the United States also suffer from chronic pain, which reinforces a negative cycle of negative...
The role of STEAP4 in retinal pathogenesis and diabetic retinopathy
Twenty-five percent of the Veterans receiving care from the VA are being treated for diabetes. Consequently, more than half suffer from diabetic retinopathy, which is an incurable...
Teaching Youth & Families Self-Regulation Skills to Disrupt the Impact of Adverse Childhood Experiences: Preventing Substance Use in Adversity-Impacted Youth
PROJECT SUMMARY/ABSTRACT Adverse Childhood Experiences (ACEs) constitute a serious public health issue, impacting almost half of adolescents and over 60% of adults in the United St...
AI-based Clinical decision support to idenTify wOmeN for HIV testing and PrEP in Florida (ACTION-HIV)
ABSTRACT With the highest HIV incidence rates observed in the US, Florida strives to develop effective and sustainable HIV prevention strategies. HIV screening and pre-exposure pro...
Epigenetic regulation of astrocyte-specific NLRP6 inflammasome and PANoptosis in HIV Tat and methamphetamine-mediated neuroinflammation
Project Summary: According to the Centers for Disease Control and Prevention, HIV infection and drug abuse are intertwined epidemics that limit adherence to combination antiretrovi...
Mitigating Genomic Research Disparities in the Million Veteran Program
To study and improve healthcare outcomes for our Veterans, the Million Veteran Program (MVP) has collected genetic and electronic health record (EHR) data from more than 650,000 Ve...
In vivo CAR-T-cell HIV therapy using in vitro reconstituted virus-like particles
PROJECT SUMMARY/ABSTRACT “Killer” (“cytotoxic”) T cells are the cells of the immune system that have the job of killing cancerous and virus-infected cells. But they do so only if t...
The neuroprotective role of proliferative reactive astrocytes in the hippocampus, synapse preservation and regeneration following traumatic brain injury
Abstract Astrocytes react to brain injury with progressive changes in gene expression, morphological hypertrophy, and proliferation referred as astrogliosis. The beneficial or detr...
Glucocorticoids in short- and long-term critical illness outcomes
ABSTRACT Because of the high mortality, morbidity, and health care costs associated with critical illness, identifying biological mechanisms that can be targeted to improve critica...
Augmenting focused ultrasound-mediated drug delivery to brain tumors with vascular normalization
The blood-tumor barrier (BTB) hinders the delivery and penetration of systemically administered therapeutic agents into the brain tumor microenvironment. The BTB is created by dila...
Develop universal CAR macrophage cell therapy for pancreatic cancer
SUMMARY/ABSTRACT Macrophages (Mφs) are innate immune cells, phagocytes and professional antigen presenting cells, which are crucial for tissue homeostasis and adaptive immune respo...
Mechanisms of Cellular Maintenance
Abstract Numerous animal cell types have extended post-developmental lifespans, necessitating robust mechanisms for cellular maintenance. Cellular maintenance deteriorates in condi...
Molecular mechanisms of sympatho-excitation in cardiovascular disease
Project summary/abstract Cardiovascular disease is the leading cause of death worldwide, and overactivity of the sympathetic branch of the autonomic nervous system (sympatho-excita...
Nuclear skeletal muscle alpha-actin and intranuclear rod myopathy
ABSTRACT Pathogenic variants in ACTA1, which encodes skeletal muscle-specific α-actin (SKA), cause a range of congenital myopathies; at the severe end of the disease spectrum are p...
Engineering bZIP family transcription factors for therapeutic T-cell persistence and effector function
PROJECT SUMMARY Cancer immunotherapy using T cells engineered with a chimeric antigen receptor or T-cell receptor directed against cancer antigens is a promising new therapeutic mo...