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99,167 grants found
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Real-Time Monitoring of Relapse in Eating Disorders
Project Summary/Abstract Eating disorders (EDs) are severe mental illnesses with high mortality,1 few effective treatments,2–4 and high relapse rates.5 Current evidence-based treat...
Ahead of the Curve: Early detection and monitoring of learning decrements in Alzheimers disease
Project Summary/Abstract Early detection and sensitive tracking of cognitive changes related to Alzheimer’s disease (AD) are critical for identifying individuals at-risk for declin...
Understanding and Improving Palliative Care Delivery among Persons with Alzheimer's Disease and Related Dementias (ADRD): A Mixed-Methods Study
PROJECT SUMMARY The over 6 million Americans with Alzheimer’s Disease and Related Dementias (ADRD) are particularly vulnerable to burdensome, low-quality, and costly care at the en...
Mechanisms of chimeric DPR production and toxicity in c9ALS/FTD
PROJECT SUMMARY/ABSTRACT Expanded GGGGCC (G4C2) hexanucleotide repeats in the C9orf72 gene were recently identified as the most common genetic cause of Amyotrophic Lateral Sclerosi...
Towards a targeted therapy for Hailey Hailey Disease
SUMMARY Hailey Hailey Disease (HHD), also known as benign chronic pemphigus, is a rare, autosomal dominant skin disorder that affects the adhesion of epidermal keratinocytes. HHD i...
Taking Our Shot: Extended-Release Naltrexone as Opioid Overdose Pre-Exposure Prophylaxis (PrEP) in People Using Stimulants Living With or At Risk of HIV
PROJECT SUMMARY Cocaine and methamphetamine-related deaths have risen steeply in the United States, the majority associated with fentanyl. Stimulant use is prevalent among people l...
Macrophage-Targeted Drug Delivery Depot for Obesity and Comorbid Type 2 Diabetes
ABSTRACT More than 42% of adults in the United States live with obesity, a condition characterized by excess body fat primarily within adipose tissue. Obesity is a risk factor for...
Mechanisms by which ICP3 Overcomes Vibrio cholerae Phage Defenses
PROJECT SUMMARY Bacteriophages (phages) are bacteria-specific viruses. Phages play a major role in the life cycle and evolution of Vibrio cholerae, the bacteria that causes cholera...
Advancing the small molecule drug candidate with dual specificity as a therapy for dry AMD
Age-related macular degeneration (AMD) is the predominant cause of blindness in the United States. Lipofuscin accumulation in the retina, which increases with age, is implicated in...
Innovations in diagnosis for lymphadenopathy across HIV Centers of Excellence in Malawi
ABSTRACT In SSA, deaths occur in 5-10% of PLWH during the first year after initiating antiretroviral therapy (ART) and causes for these early deaths are not well elucidated in most...
Sleep and Brain Thermoregulation
Title: Sleep and brain thermoregulation: Abstract We have found that human hunter-gatherers sleep nearly an hour more in winter than in summer and that less than 2% of this populat...
Repositioning Immunotherapy in Veterans with Lung Cancer
PROJECT SUMMARY Lung cancer is the deadliest cancer in American war Veterans. Due to limited uptake in lung cancer screening, one third of patients present locally advanced (Stage...
The Role of CCL11 in Inflammatory and Sporadic Colorectal Cancer.
With more than 3 million Americans affected, inflammatory bowel disease (IBD) causes significant morbidity and can progress to colorectal cancer (CRC). There are two main forms of...
Development of Robust Corneal Biomechanical Biomarkers for Glaucoma Using Brillouin Microscopy
Project Summary: While elevated intraocular pressure (IOP) is the only modifiable risk factor for glaucoma, up to one third of patients have glaucoma at normal IOPs and patients wi...
Does Altered Brain Connectivity Correlate with Developmental Outcomes and Executive Function in Congenital Heart Disease?
Congenital heart disease (CHD) is the most common birth defect in the U.S. and affects ~1% of all live births. Over 85% live well into adulthood, and over 50% of those with moderat...
Neural biomarkers of sensory symptoms in autism
Project Summary Sensory symptoms are a core diagnostic feature of autism and cause substantial functional impairment. Auditory processing is one of the most affected domains and is...
Domain-adaptive federated learning to develop machine learning models for predicting incident and progression of geographic atrophy
Abstract: Age-related macular degeneration (AMD) is one of the leading causes of severe vision loss. Early detection, prompt intervention, and reliable assessment of treatment outc...
Using Forward Genetics to Explore the Genetics and Mechanisms of Early Onset Glaucoma
Project Summary The pathways regulating the development of early-onset glaucoma are not well understood. Despite evidence suggesting that a large proportion of early-onset glaucoma...
Genomics-guided sleep biomarker discovery for early Alzheimer's disease: A wearables study
PROJECT SUMMARY This proposal is responsive to NIA solicitation PAR-22-093/NOT-AG-21-048 for projects involving the development of digital technology for the early detection of Alz...
Decoding the Mechanism of Pathogenic Enhancer Mutations In Congenital Limb Disorders
PROJECT SUMMARY Regulatory regions of the genome play crucial roles in ensuring appropriate spatiotemporal expression of genes. Like other regions of the genome, regulatory DNA seq...