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99,167 grants found
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Novel Incidental Calcium Evaluation (NICE)
1 PROJECT SUMMARY 2 Coronary artery calcium (CAC), typically measured on gated computed tomography (CT) scans, is the 3 strongest predictor of atherosclerotic cardiovascular diseas...
A Pilot Effectiveness Trial of an Adapted App-Based Mindfulness Intervention for Pre-Service Teachers
PROJECT SUMMARY/ABSTRACT Mental health concerns in teachers have escalated since the onset of the pandemic, and the deterioration of mental health can begin as early as the teacher...
Molecular and cellular mechanisms underlying Fgf8-dosage mediated defects in jaw size and symmetry
PROJECT SUMMARY Craniofacial malformations are among the most common human birth defects. Tissues of the head and neck derive from the pharyngeal arches (PAs). PAs are transient de...
Examining how visual experience modulates the thalamus and visuomotor responses.
SUMMARY Vision is how most organisms perceive and respond to their environment, making the development and function of this sensory modality paramount. Visual experience is necessa...
Regulation of Elevated Postexercise Insulin-stimulated Glucose Uptake by Skeletal Muscle
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Over 130 million Americans suffer from the devas...
Imaging Alterations in Endocannabinoid Metabolism in Depression and Suicide
Project Summary Strong epidemiological evidence linking cannabis use to depression and suicide suggests that the endocannabinoid (eCB) system plays a key role in its pathophysiolog...
p75NTR regulates oligodendrocyte progenitor development in the SubventricularZone of postnatal rats
Summary Generating the appropriate numbers of cells in a particular lineage is critical for normal development of the brain. Progenitor cells of both neuronal and glial lineages ar...
Optimization of genetically encoded voltage and neurotransmitter indicators for multiwavelength in vivo analysis of brain circuits
The brain is remarkably dynamic, adaptive, and flexible in response to environmental changes. These capacities are enabled by diverse cell types which communicate with an array of...
Epitranscriptomics in human obesity and type 2 diabetes
PROJECT SUMMARY Dysfunction of multiple metabolic cells contribute to the pathophysiology of the two major pathological states, obesity and type 2 diabetes, which have a huge econo...
Molecular regulators of GABAergic systems that underlie comorbidities in Down syndrome
PROJECT SUMMARY Down syndrome (DS), which is caused by full or partial trisomy of human chromosome 21 (Hsa21), presents various neurological features, including intellectual disabi...
Optimizing lipid nanoparticles for retinal gene editing in the NHP
PROJECT SUMMARY Inherited retinal dystrophies (IRDs) are a group of genetically and clinically heterogenous diseases, inherited in an autosomal dominant, recessive, or X-linked pat...
Effects of Medication for Opioid Use Disorder on Microglial Activation and Neurocognition in People Living with HIV
PROJECT SUMMARY/ABSTRACT The goal of this proposal is to compare and contrasts the effects of different medications for opioid use disorder (MOUD) on driving abnormal immune activa...
Knowledge-guided automated machine learning methods for modeling the interaction of HIV with addictive drugs
The primary goal of this project is to bring powerful data mining and analytics methods, as well as computing technology and technical software, to the substance abuse and HIV rese...
Functional connectivity mechanisms of opioid abstinence
Abstract Opioid use disorder (OUD) is a significant public health problem with opioid-associated overdoses and deaths reaching epidemic levels in recent years. Methadone and bupren...
Quantitative Ultrasound To Diagnose Nonalcoholic Fatty Liver Disease in Children.
SUMMARY Our broad long-term objective is to improve the health of children with nonalcoholic fatty liver disease (NAFLD), a condition characterized by accumulation of fat in liver...
Arginase positive monocyte mediated RGC neuroprotection after traumatic optic neuropathy
Project Summary: Acute retinal ganglion cell (RGC) and optic nerve injury due to trauma, autoimmune inflammation, and ischemia reperfusion results in permanent disability due to ev...
Addressing financial hardship in adolescent and young adult cancer survivors: Efficacy and implementation of a multilevel intervention in community-based oncology practices
Project Summary Adolescent and young adult cancer survivors (AYAs; ages 15-39-years) are an important underserved group at risk for significant financial hardship. There are nearly...
Morphogenetic signaling from the cell surface to the nucleus during vertebrate eye development
Hedgehog Signal Transduction from the Cell Surface to the Nucleus during Vertebrate Eye Development The Hedgehog (Hh) pathway is essential for eye development, controlling a divers...
RXR-based therapy for diabetic retinopathy
An excess of circulating lipids in conjunction with dysregulated retinal de novo lipogenesis results in retinal lipotoxicity which can lead to retinal inflammation and apoptosis co...
Mitochondria: controllers of trauma-induced secondary neurodegeneration onset
Each year approximately 3 million United States citizens incur traumatic brain injury (TBI). An additional 50,000 United States citizens derive permanent vision loss from direct oc...