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99,167 grants found
Showing 5,181 – 5,200 of 99,167 grants
Establishing Acomys as a genetic platform for regeneration research
PROJECT SUMMARY Many of the major biological discoveries of the 20th century were made using very few model species. They were chosen for historical experimental tractability, rath...
COMPASS: A comprehensive mobile precision approach for scalable solutions in mental health treatment
Matching patients to the treatment most effective for them can accelerate recovery and meaningfully reduce the growing burden of mental health conditions. Key barriers to tailoring...
Defining The Substrates of Acyl Protein Thioesterase-1: Their Role in Modulating Alpha-Synuclein Toxicity
The neuronal protein alpha-synuclein (αS) plays a key role in the group of neurodegenerative diseases known as synucleinopathies: Parkinson disease (PD), Parkinson disease dementia...
Establishment and Validation of a Novel Animal Model of Fibromyalgia
Fibromyalgia (FM) is a chronic debilitating pain condition that affects about four million people in the U.S. alone. Current treatment of FM focuses on symptomatic management becau...
Visual perception and the medial temporal lobes
Summary: The overall goal of the proposal is to determine the role of the medial temporal lobe (MTL) in visual perception and working memory. Although it is well established that t...
Best Practices to Return Results About Pesticide Exposures in Family Child Care Homes
Abstract The goal of this study is to develop best practices for returning results to family child care home (FCCH) directors about pesticides present in their facilities. Best pra...
Developmental Trajectories of Sleep EEG Biomarkers and Risk of Psychopathology Through Young Adulthood
Project Summary The brain undergoes anatomical and physiological changes with the onset of puberty, of which synaptic pruning and increased myelination in a posterior-to-anterior g...
Identification of gene regulatory networks controlling temporal patterning in retinal progenitor cells and neurogenic Müller glia
Project Summary: Over the course of developmental neurogenesis, retinal progenitor cells show progressive changes in their ability to generate specific cell types, and become progr...
EndMT as a target to treat human brain arteriovenous malformations
Project Summary Brain arteriovenous malformation (bAVM) is a high-risk factor for intracerebral hemorrhage (ICH), which leads to a high rate of disability or death. However, the tr...
Dissecting the role of germline genetic variation and viral exposures as determinants of hematological disease predisposition
ABSTRACT The role of germline genetic variation and viral infection in development and progression has been studied extensively in adult tumors and autoimmune disease. Less attenti...
A pulse-driven micropump for continuous drug delivery
A pulse-driven micropump for transdermal drug delivery PROJECT SUMMARY/ABSTRACT Ambulatory infusion pumps are an increasingly prescribed therapy modality for cancer and diabetes pa...
tRNA Gene Replacement Therapy for tRNA-Synthetase Related Charcot-Marie-Tooth Disorder
PROJECT SUMMARY/ABSTRACT Charcot-Marie-Tooth disease (CMT) is a collection of inherited peripheral neuropathies with a cumulative incidence of ~1:2500 people. There is no approved...
Pilot feasibility study of the WHO LIVE LIFE guide with DHMT as Champions for Suicide Prevention (WLLDC-SP)
Abstract Mbarara University of Science and Technology (MUST) developed and successfully implemented the ‘Building Capacity for Implementation Science in Non-communicable Diseases (...
Development of NAT8L inhibitors for the Treatment of Canavan Disease
PROJECT SUMMARY Canavan disease (CD) is an autosomal recessive inherited leukodystrophy caused by the mutations in ASPA gene encoding the aspartoacylase enzyme, leading to loss of...
Neuroeconomic mechanisms of counterfactual thinking
PROJECT SUMMARY / ABSTRACT There is a fundamental gap in understanding how neurons integrate hypothetical information when making decisions. This includes not only predicting futur...
NDRGs as mediators of hypoxia adaptation
PROJECT SUMMARY Oxygen is essential for the life of many organisms, as it used during aerobic respiration to generate cellular energy in the form of adenosine triphosphate (ATP). L...
Metabolic Control of Cardiac Pacemaking
Project Summary The cardiac cycle starts with the production of an action potential (AP) by pacemaking cells in the sino-atrial node (SAN), initiating the propagation of electrical...
Engaging Youth, Caregivers, and Teachers for Suicide Prevention: Developing and Implementing a Multi-Level Intervention in Rural China
PROJECT SUMMARY This collaborative project between Brown University and Beijing Normal University responds to RFA-MH-23-260 by developing and testing a multi-level intervention pro...
A causal wiring diagram of transdiagnostic brain functions
Brain imaging has long been criticized for revealing correlations rather than causes.In recent years, there has been a rapid growth of focal brain stimulation technology, which can...
Development and validation of a high throughput screening assay for identification of tau aggregation inhibitors in Alzheimer's disease
Abstract Alzheimer's disease (AD) is the most common type of dementia affecting a large percentage of the elderly population. A hallmark event in AD is the brain accumulation...