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Showing 501520 of 99,167 grants

Active NON-SBIR/STTR RPGS
TBI-ADRD Modeling with a Team Science Approach (TBI-ADRD Team Science)
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND S... Morehouse School of Medicine United States 2024 – 2027

Abstract Summary We hypothesize that we can increase systemically develop a progressive murine TBI-ADRD model with internal and external validity with a “Team-Science”-based two-ph...

$22.83M
USD
Active NON-SBIR/STTR RPGS
Laminar Circuit Motifs for Working Memory and Language Combinatorics: From Cells to Systems
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND S... University of Iowa United States 2024 – 2029

PROJECT SUMMARY / ABSTRACT Language gives meaning to our inner thoughts, interacting with cognitive functions that flexibly manipulate sensory content in mind. Language combinatori...

$12.17M
USD
Active NON-SBIR/STTR RPGS
Sleep, pain, and recovery in kids after pediatric intensive care (SPARK-PICU)
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Oregon Health & Science University United States 2024 – 2029

Project Summary More than 250,000 children survive pediatric intensive care unit (PICU) hospitalization each year in the United States, yet we have an incomplete understanding of r...

$7.37M
USD
Active NON-SBIR/STTR RPGS
Supporting Just-in-Time Consent for Prenatal Screening in Diverse Populations
NATIONAL HUMAN GENOME RESEARCH INSTITUTE Mayo Clinic Jacksonville United States 2024 – 2028

PROJECT SUMMARY/ABSTRACT Prenatal screening for genetic conditions (PGS) has changed the landscape of prenatal care by offering noninvasive indication of some fetal genetic conditi...

$8.12M
USD
Active NON-SBIR/STTR RPGS
An Injectable Electrode to Better Isolate the Posterior Tibial Nerve to Treat OAB
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND S... University of Wisconsin-Madison United States 2024 – 2029

Abstract Urinary urgency, with or without incontinence, greatly affects the quality of life in individuals suffering from Overactive Bladder (OAB). A sudden and often overwhelming...

$6.28M
USD
Active NON-SBIR/STTR RPGS
Building Safety Guards into LLMs for Trustworthy Automatic Simplification of Medical Documents
NATIONAL LIBRARY OF MEDICINE University of Texas At Austin United States 2024 – 2028

Abstract Texts describing medical advances are of keen interest to the general public. However, reliable medical evidence is largely disseminated in peer-reviewed journal articles...

$3.64M
USD
Active NON-SBIR/STTR RPGS
Uncovering Causal Protein Markers to Characterize Pancreatic Cancer Etiology and Improve Risk Prediction
NATIONAL CANCER INSTITUTE University of Hawaii At Manoa United States 2024 – 2029

Pancreatic cancer (PC) is the third leading cause of cancer mortality in the United States. The vast majority of PC are pancreatic ductal adenocarcinoma (PDAC). The etiology of PDA...

$7.37M
USD
Active NON-SBIR/STTR RPGS
Hemin Production by Veillonella: A Novel Mechanism in Inhibiting P. gingivalis Hemolysis
NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEAR... University of Texas Hlth Sci Ctr Houston United States 2024 – 2026

SUMMARY/ABSTRACT Periodontal disease, a widespread global health issue, predominantly originates from dental plaque, which an intricate polymicrobial biofilm. Within this milieu, V...

$4.29M
USD
Active NON-SBIR/STTR RPGS
Confidentiality in use of health insurance coverage for reproductive health services
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD... Brigham and Women'S Hospital United States 2024 – 2026

Enhancing Policy Impact for Reproductive Health Equity (EnPIRHE) Project Summary/Abstract- 30 lines The World Health Organization affirms that sexual and reproductive health (SRH)...

$4.95M
USD
Active NON-SBIR/STTR RPGS
Effect of aerosolized tobacco and cannabis products on Streptococcus mutans and Candida albicans interkingdom cariogenicity
NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEAR... University of California Los Angeles United States 2024 – 2026

PROJECT SUMMARY Vaping of aerosolized tobacco and cannabis products using electronic nicotine delivery devices (ENDS) is increasingly popular among adolescents and young adults. Th...

$2.36M
USD
Active NON-SBIR/STTR RPGS
Distance-based Exercise to preserve Function and prevENt Disability (DEFEND)
NATIONAL CANCER INSTITUTE Dana-Farber Cancer Inst United States 2024 – 2027

PROJECT SUMMARY Many cancer survivors experience challenges in performing daily activities and loss of work productivity due to the adverse effects of cancer and its treatments, re...

$2.95M
USD
Active NON-SBIR/STTR RPGS
Partners in Research: Building capacity for community-driven research to advance health equity
NATIONAL CANCER INSTITUTE University of Michigan At Ann Arbor United States 2024 – 2029

ABSTRACT Structural factors of health inequities are the systemic and societal conditions that contribute to disparities in health among different populations. These disparities of...

$7.49M
USD
Active NON-SBIR/STTR RPGS
Federated learning algorithms to overcome statistical and algorithmic bias and privacy concerns in machine learning for health
NATIONAL LIBRARY OF MEDICINE Columbia University Health Sciences United States 2024 – 2028

Project Summary Federated learning has emerged as a promising technique in biomedical research, providing the potential to construct robust common machine learning models with data...

$3.58M
USD
Active NON-SBIR/STTR RPGS
Cultivating programmatic efforts to optimize the conduct and implementation of NCI-funded clinical trials
NATIONAL CANCER INSTITUTE Vanderbilt University Medical Center United States 2024 – 2029

Dr. Cathy Eng is an exemplary Clinician Scientist who, throughout her career, has held numerous roles within the National Clinical Trials Network (NCTN) and is viewed, by her peers...

$1.3M
USD
Active NON-SBIR/STTR RPGS
Neural Correlates of Cognitive-Motor Interactions in ADRD Gait
NATIONAL INSTITUTE ON AGING University of Florida United States 2024 – 2029

PROJECT SUMMARY NIH RFA AG-24-041 requests applications to determine the neural mechanisms that underlie the association between gait and cognition in aging and Alzheimer's di...

$8.05M
USD
Active NON-SBIR/STTR RPGS
Comprehensive Analysis and Multi-Omics Data Integration for Cancer-Related Studies
NATIONAL CANCER INSTITUTE Johns Hopkins University United States 2024 – 2029

Project Summary/Abstract I am a principal data scientist and bioinformatics manager of The Experimental and Computational Genomics Core in the Sidney Kimmel Comprehensive Cancer Ce...

$1.57M
USD
Active NON-SBIR/STTR RPGS
Vulnerability of the ascending arousal network to alpha-synuclein pathology
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND S... University of Iowa United States 2024 – 2027

Cognitive fluctuations –termed “the Lewy Body Roller Coaster” by some families – are a debilitating symptom of Lewy body disorders (LBD), an Alzheimer’s disease related disorder th...

$22.35M
USD
Active NON-SBIR/STTR RPGS
IGF-1 and Innate Immunity in Neonatal Brain Injury
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND S... Medical University of South Carolina United States 2024 – 2029

Abstract Neonatal Intraventricular hemorrhage (IVH) originates from the underdeveloped germinal matrix, a site of cellrapid cell division adjacent to the lateral ventricles of the...

$4.4M
USD
Active NON-SBIR/STTR RPGS
POINT of CARE: PrOviding an Innovative New Triage and Treatment strategy for Cervical cAncer scReening Efficiency
NATIONAL CANCER INSTITUTE Basic Health International, Inc United States 2024 – 2029

PROJECT SUMMARY Although preventable, cervical cancer is a leading cause of mortality in low- and middle-income countries (LMIC). Infection with high-risk human papillomavirus (HPV...

$4.81M
USD
Active NON-SBIR/STTR RPGS
Novel Statistical Models for Intensive Longitudinal Analyses of Cancer Control Behaviors
NATIONAL CANCER INSTITUTE University of Chicago United States 2024 – 2028

PROJECT SUMMARY This project will develop, test, apply, and disseminate multilevel statistical models and software for estimating effects of intraindividual means, variances, slope...

$6.5M
USD