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99,167 grants found
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Stem Cell-based Modeling of Placental Defects associated with Early-Onset Preeclampsia
Project Summary/Abstract Preeclampsia (PE) is a multifactorial pregnancy syndrome that affects up to 10% of pregnancies worldwide, and is defined by new onset of hypertension and p...
Selective Inhibition of GRP 94 to Treat Ocular Hypertension and Glaucoma
Project Summary The accumulation of mutant myocillin leads to decreased aqueous humor outflow and results in ER dysfunction. Grp94 is a major chaperone localized to the ER that is...
Understanding the mechanism of rescue of Alzheimers disease by hematopoietic stem cell transplantation
Project Summary Alzheimer’s Disease (AD) is the most prevalent cause of dementia and the most common age-related neurodegenerative disorder characterized by the progressive degrada...
Functional and therapeutic roles of the Hedgehog signaling in meibomian glands development, renewal and dysfunction
Meibomian gland disease (MGD) is considered the leading cause of dry eye disease, a common multifactorial disease with a global prevalence of 5 to 50% and a major age-related disea...
Cerebral Energy Metabolism in ME/CFS with and without PASC
Project Summary Many patients who have recovered from SARS-CoV-2, the virus that causes COVID-19, continue to experience a constellation of symptoms long after the initial illness....
Mechanisms Governing Nerve-Mediated Control of Corneal Wound Healing: New Hope for Patients with Neurotrophic Keratopathy
PROJECT SUMMARY: Overview: The molecular mechanisms by which corneal nerves regulate limbal stem cells (LSCs), required for corneal epithelial maintenance and wound healing, and ul...
Identifying and Addressing Barriers in the Cervical Cancer Treatment Cascade among Women with HIV in South Africa
PROJECT SUMMARY/ABSTRACT The vast majority of women who develop and die from cervical cancer live in low- and middle-income countries.1 In sub-Saharan Africa, geographic inequities...
Novel Cre-Dependent AAVs with Minimal Off-Target Expression to Study Neural Circuits
Key tools for studying neural circuits combine Cre recombinase dependent expression of either: markers (GFP), optogenetic and chemogenetic actuators (e.g. channelrhodopsin and DREA...
Homemaker Home Health Aide Use and Veteran-Centered Outcomes
PROJECT SUMMARY. Persons with substantial functional disabilities--multiple limitations in activities of daily living (ADLs)--overwhelmingly prefer to remain at home. The VA faces...
Evaluating the Impact of Medical Foster Home Coordinator Effort and Experience on Costs
This project will address the HSR&D Long-Term Care and Aging priority by investigating Medical Foster Homes (MFHs) as a community-based long-term care (LTC) alternative, and in...
A learning health system approach to using Artificial Intelligence Enabled Decision Support (AEDS) for medication optimization in Veteran Care: An Immunosuppressants use case
Background: In the modern era of drug development, drug manufacturers are regularly introducing novel medications that require a wide range of resources that may increase the burde...
Molecular tools for precise manipulation of defined synaptic connections
Project Summary/Abstract Our project will address a major gap in existing neuroscience research tools, through the development of intersectional genetic tools for drug-controlled m...
Lung Cancer Screening for Veterans Enrolled in Community Care: Modifiable Mechanisms to Improve Patient-Centered Outcomes
Background: VA recommends all eligible Veterans be offered lung cancer screening (LCS) using annual low dose computed tomography (LDCT). VA is working to increase the number of Vet...
Increasing Veterans' Social Engagement and Connectedness (CONNECTED)
Background: Social isolation is a global public health threat and a negative social determinant of health (SDoH) that affects 1 in 5 adults in the U.S. and contributes to $6.7 bill...
Hearing Loss, Prognosis, and Long-Term Impact of Otitis Media with Effusion in Children
PROJECT SUMMARY/ABSTRACT Otitis media with effusion (OME) is a common childhood condition characterized by a non-purulent effusion in the middle-ear space. OME can cause conductive...
Project ACCESS: Advancing Equitable Access to HIV/HCV Testing Through Structural Transformation in Syringe Services Programs: A Cluster Randomized Trial
1 ABSTRACT The National HIV Strategy encourages expansion of HIV testing to community health settings, emphasizing it is critical that all people, particularly high incidence group...
Studies of direct and transthalamic pathways in visual cortex
PROJECT SUMMARY Few structures in the brain are as prominent, yet poorly understood, as the pulvinar. The pulvinar is both large and complex, having undergone more expansion with p...
Prenatal Cannabis: Effects on Developmental Milestones, Disinhibition, and Substance Initiation
Project Summary/Abstract Along with alcohol and tobacco, cannabis use amongst pregnant women is increasing in the United States. Therefore, it is necessary to identify the persiste...
Digital Twins from the Atom to the Rhythm
PROJECT SUMMARY: Our overarching goal is to develop a transformative integrative clinical, experimental and in silico-based pipeline to create a digital twin technology for patient...
Structure-guided cancer immunotherapy design with HLA-Arena and CrossDome
Project Summary The broader use of T-cell-based therapies is still hindered by challenges related to the identification of peptide- targets that are both immunogenic (capable of act...