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99,167 grants found
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Advancing Decisions about Virtual Service Encounters (ADViSE)
Background: Expanded availability of virtual care options in Primary Care provides new opportunities to improve Veterans’ outcomes by aligning encounter modalities with their needs...
Deciphering the Roles of STING-Mediated T cell Pyroptosis in Antitumor Immunity
PROJECT SUMMARY An immunosuppressive tumor microenvironment presents a significant hurdle in controlling tumor growth. Activation of the stimulator of interferon genes (STING) prot...
Investigating Photoreceptor Nuclear Migration Defects Caused by Loss of Retinitis Pigmentosa 2.
ABSTRACT Retinal inherited diseases are a leading cause of blindness worldwide. Despite major progress in the discovery of causative genes underlying inherited retinal disease, und...
Targeting Interleukin-6 cis-trans balance in Müller cell dysfunction
Project Summary Diabetic retinopathy (DR) is a sight-threatening neurovasculopathy and the leading cause of blindness in adults. The number of DR patients is growing, but therapeut...
Utility of Random Biopsies in Inflammatory Bowel Disease
PROJECT SUMMARY Patients with long standing inflammatory bowel diseases (IBD) have an increased risk of colorectal cancer (CRC) as a consequence of chronic inflammation. To reduce...
The physiological and genetic basis of gestational adaptations to hypoxia
Hypoxia is a common feature of gestational complications. Even when the origins of hypoxia vary (i.e., environmental hypoxia versus hypoxia limited to the placenta), there are shar...
Pediatric Cardiopulmonary MRI using RF Navigators and High Dimensional Deep Learning
ABSTRACT The cardiac and pulmonary systems are inherently linked through the pulmonary vascular system which leads to secondary pulmonary disease in cases of cardiac pathology. Thi...
Biomechanics of the Human Optic Nerve Head for Glaucoma Biomarkers.
SUMMARY Glaucoma is a leading cause of blindness in the United States and worldwide. The disease is characterized by the death of retinal ganglion cells after the initial injury to...
A 4D-tunable hydrogel for the study of the impact of the tumor microenvironment on the development of colorectal cancer
Project Summary/Abstract The goal of this proposal is to develop a platform created from advanced biomaterials that enable novel investigations into the physiochemical roles of the...
High-throughput biochemistry with RNA-barcoded proteins
PROJECT SUMMARY Vast numbers of mutations in human protein coding sequences have been identified by DNA sequencing, but for only a tiny percentage of these variants do we understan...
Stargardt/ABCA4 disease in African Americans
Project summary/Abstract Disease-associated variation in the ABCA4 gene has emerged as the most prevalent cause of Mendelian retinal disease affecting an estimated 50,000 people in...
Unraveling Neural Diversity: Decoding the Cellular and Molecular Mechanisms of Neural Circuit Formation and Function in the Drosophila Central Complex
Summary: A key question in neurobiology is how neural stem cells (NSCs) produce the vast diversity of neural subtypes required for precise control of behavior. The human cortex is...
BEST CARE for Recurrent NMIBC: BladdEr-Sparing Therapy and Cystectomy As TREatments
PROJECT SUMMARY/ABSTRACT Bladder cancer is the 6th most common cancer in the US and the 4th most common cancer in males. Each year, more than 80,000 people in the US are diagnosed...
Multi-omics Strategies to Improve Clinical Outcomes in Uveitis
PROJECT SUMMARY Uveitis is an inflammatory eye disease that confers severe ocular morbidity and can cause long term blindness if not diagnosed and treated promptly. Current challen...
Modulation of Outflow Facility and Biomechanics
PROJECT SUMMARY Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness, and elevated intraocular pressure (IOP) is the primary risk factor. By 2040, it is...
Topical delivery of HIF-1 inhibitors for retinal and choroidal vascular diseases
PROJECT SUMMARY Injectable therapies for blocking vascular endothelial growth factor (VEGF) have provided impressive initial benefits to most patients with neovascular age-related...
Comprehensive prospective correction of head motion in functional MRI
Project Summary/Abstract Functional magnetic resonance imaging (fMRI) is widely used to study how the human brain interacts with the world and how regions of the brain function as...
Developing an integrated system for detailing the conformational flexibility, heterogeneity, and dynamics of functional oligonucleotides
Abstract/Summary Despite the nearly 4 decades of technology development for biomolecular structure analysis since the discovery of the ribozyme, researchers still grapple with an i...
Microscale Multiplexed Antibody Fc Profiling and Nanoscale Electronic Detection for Rapid and Scalable Point-of-Care Diagnosis of Tuberculosis
Tuberculosis (TB), caused by M. tuberculosis (Mlb) infection, is one of the leading causes of infectious disease related death globally despite the availability of treatments. Lack...
Enhancing Rigor and Reproducibility of Translational Nonhuman Primate Models for Genetic and Regenerative Therapies
This application is submitted in response to PAR-23-040 with the goal of integrating cutting-edge in vivo imaging technologies and key immunologic assessments to enhance the rigor...